Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2020
Objective: To establish a stable and rapidly rat model acquired aplastic anemia.
Methods: The SD rats were exposed to Csγ-ray at 3.5 and 4.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
April 2019
Objective: To improve and establish the mouse model with aplastic anemia (AA) mediated by Cs γ-ray irradiation combined with cyclophosphamide (CTX) and chloramphenicol (CHL) injection,so as to provide a stable model for studying the pathogenesis and treatment of AA .
Methods: The BALB/c mice were exposed to Cs γ-ray of 3-5 Gy(91 cGy/min) and were intraperitoneally injected with CTX of 25 mg/(kg.d) and CHL of 62.