A randomized, double-blind, placebo-controlled phase I clinical trial of rotavirus inactivated vaccine (Vero cell) in a healthy adult population aged 18-49 years to assess safety and preliminary observation of immunogenicity.

We conducted a phase I, randomized, double-blind, placebo-controlled trial including healthy adults in Sui County, Henan Province, China. Ninety-six adults were randomly assigned to one of three groups (high-dose, medium-dose, and low-dose) at a 3:1 ratio to receive one vaccine dose or placebo. Adverse events up to 28 days after each dose and serious adverse events up to 6 months after all doses were reported.

Adverse Events Associated with Nirmatrelvir/Ritonavir: A Pharmacovigilance Analysis Based on FAERS.

Nirmatrelvir/ritonavir is approved for the treatment of adults and pediatric patients with mild to moderate COVID-19, but information on adverse events associated with its use is limited. We aim to evaluate adverse events with potential risk for nirmatrelvir/ritonavir using the FDA Adverse Event Reporting System (FAERS). Disproportionality analysis was performed using the reporting odds ratio (ROR) method, and subset analysis based on patient age and gender, as well as sensitivity analysis restricting the type of reporter to healthcare professionals.

A meta-analysis of efficacy and safety of S-1 monotherapy or combination therapy as first-line treatment in metastatic colorectal cancer.

Purpose: To compare the efficacy and safety profile of S-1-based versus non-S-1-based chemotherapy as first-line treatment in mCRC.

Methods: Relevant randomized controlled trials (RCTs) were obtained from PubMed, Embase, and Ovid databases and the Cochrane library from database set up in May 2018. The RCTs of S-1-based monotherapy or combination therapy as first-line treatment were selected.

Convenient chirality transfer from organics to titania: construction and optical properties.

Polyethyleneimine (PEI) complexed with chiral d- (or l-) tartaric acid (tart) in water can self-organize into chiral and crystalline PEI/tart assemblies. It has been previously confirmed that the complexes of PEI/tart could work as catalytic/chiral templates to induce the deposition of SiO nanofibres with optical activity but without outwards shape chirality such as helices. In this work, we found that the templating functions of PEI/tart were still effective to prompt the deposition of TiO to form chiral PEI/tart@TiO hybrid nanofibres under aqueous and room temperature conditions within two hours.

Circularly Polarized Luminescence from Inorganic Materials: Encapsulating Guest Lanthanide Oxides in Chiral Silica Hosts.

Recently, circularly polarized luminescence (CPL)-active systems have become a very hot and interesting subject in chirality- and optics-related areas. The CPL-active systems are usually available by two approaches: covalently combining a luminescent centre to chiral motif or associating the guest of luminescent probe to a chiral host. However, all the chiral components in CPL materials were organic, although the luminescent components were alternatively organics or inorganics.

[Pathogenic role of leukotriene B4 in pulmonary microvascular endothelial cell hyper- permeability induced by one lung ventilation in rabbits].

Objective: To elucidate the pathogenic role of leukotriene B4 (LTB4) in increased pulmonary microvascular endothelial cell permeability induced by one lung ventilation (OLV) in rabbits.

Methods: Forty-eight healthy Japanese white rabbits were randomly divided into control group (group C), saline pretreatment group (group S), bestatin (a leukotriene A4 hydrolase (LTA4H) inhibitor) plus saline pretreatment group (group B), OLV group (group O), saline pretreatment plus OLV group (group SO) and bestatin plus saline pretreatment with OLV group (group BO). ELISA was used to detect LTB4 content in the lung tissues, and LTA4H and phospholipase Cεl (PLCEl) expressions were examined by Western blotting and quantitative PCR.

Self-directing chiral information in solid-solid transformation: unusual chiral-transfer without racemization from amorphous silica to crystalline silicon.

Constructing novel chiral inorganic nanomaterials is an emerging branch in chirality research. In this work, by employing a solid magnesiothermic reaction at 500-600 °C, we reduced chiral SiO nanofibers with average diameter ∼10 nm into chiral Si nanoplates with a size of about several hundred nm. The chirality of the as-prepared Si was judged by the pair of signals with a mirror relationship between 400-500 nm that appeared on the solid-state diffuse reflectance circular dichroism (DRCD) spectra for the l- and d-form Si.

Unexpected "Hammerlike Liquid" to Pulverize Silica Powders to Stable Sols and Its Application in the Preparation of Sub-10 nm SiO Hybrid Nanoparticles with Chirality.

Silane coupling agents are well-known as surface modifiers for various kinds of silica (SiO). However, in the present research, it has been found that they can also work as "hammerlike liquid" to pulverize different kinds of bulk amorphous SiO in aqueous systems. This new function was typically clarified by using 3-aminopropyltrimethoxysilane (APS) and bundles of chiral SiO nanofibers (with average diameter of ∼10 nm) as raw materials.

Fragment-Based Hologram QSAR Studies on a Series of 2,4-Dioxopyrimidine-1-Carboxamides As Highly Potent Inhibitors of Acid Ceramidase.

A series of structurally related 2,4-dioxopyrimidine-1-carboxamide derivatives as highly potent inhibitors against acid ceramidase were subjected to hologram quantitative structure-activity relationship (HQSAR) analysis. A training set containing 24 compounds served to establish the HQSAR model. The best HQSAR model was generated using atoms, bond, connectivity, donor and acceptor as fragment distinction and 3-6 as fragment size with six components showing cross-validated q value of 0.

Polycondensation and carbonization of phenolic resin on structured nano/chiral silicas: reactions, morphologies and properties.

In this research, we extended a bioinspired and templated synthesis way for SiO to carbonaceous materials, with the success in morphology control and inducing chirality at the nano-scale. The biopolymer-analogue polyamine, i.e.

Research progress on siRNA delivery with nonviral carriers.

RNA interference is a powerful method for the knockdown of pathologically relevant genes. Small interfering RNAs (siRNAs) have been widely demonstrated as effective biomedical genetic-therapy applications for many diseases. Unfortunately, siRNA duplexes are not ideal drug-like molecules.

[Experimental study on 5-fluourouracil-loaded immunonanoparticles targeting to lens epithelial cells].

Objective: To evaluate the immunological characteristics of an immunonanoparticles targeting to human lens epithelial cells and to study if it could internalize into and inhibit the proliferation of target cells in vitro.

Methods: Crosslinker carbodiimide was used to couple McAb HILE6 (anti-lens epithelial cells antibody) with 5-fluourouracil-loaded polyactic acid nanoparticles PLA (5-FU)-NP to prepare the immunonanoparticles HILE6-PLA (5-FU)-NP. The molar ratio of HILE6 and 5-FU in the immunonanoparticles were observed.