Publications by authors named "Xin-Jing Cui"
Article Synopsis
- This study explored cognitive profiles and changes in non-demented adults who have high Modified Dementia Risk Scores (MDRS), linking these scores to Alzheimer's disease (AD) biomarkers and neuroinflammation.
- It utilized data from 994 participants in the Chinese Alzheimer's Biomarker and Lifestyle (CABLE) database, analyzing the connection between MDRS, cognitive performance, and cerebrospinal fluid (CSF) biomarkers using statistical methods.
- Results showed that higher MDRS correlated with worse cognitive functioning and elevated levels of certain CSF biomarkers related to AD and neuroinflammation, with implications for predicting future cognitive decline.
Background: APOE ɛ4 genotype was correlated with exacerbation of pathology and higher risk of dementia in Parkinson's disease (PD). Meanwhile, the differential influence of APOE ɛ4 on cognition in young and old individuals interpreted as antagonistic pleiotropy.
Objective: To examine whether the effect of APOE ɛ4 on cognitive progression in de novo PD is age dependent.