Publications by authors named "Xin-Jia Han"
Article Synopsis
- Excess glutamate release from presynaptic neurons is linked to ischemic neuronal death, with CA1 pyramidal neurons being more vulnerable than CA3 neurons, hinting at distinct properties of these cells contributing to this difference.
- After ischemia, CA1 neurons showed increased dendritic spines and changes in glutamate receptor subunit expression, particularly a rise in the NR2B/NR2A ratio and a decrease in the GluR2 subunit.
- In contrast, CA3 neurons remained relatively unchanged in synaptic density and receptor expression post-ischemia, suggesting that structural changes in CA1 neurons drive delayed cell death following ischemic events.
The retina is a light-sensitive tissue of the central nervous system that is vulnerable to ischemia. The pathological mechanism underlying retinal ischemic injury is not fully understood. The purpose of this study was to investigate structural and functional changes of different types of rat retinal neurons and visual behavior following transient global ischemia.
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