Benzothiazole-Propanamide Linker Pyrrolidine (Morpholine) as Monoamine Oxidase-B and Butyrylcholinesterase Inhibitors.

According to the fusion technique create effective multi-target-directed ligands, in this study, we designed and synthesized a series of benzo[d]thiazol-2-yl)-3-(pyrrolidin-1-yl) or 3-(morph- olino-1-yl)propanamide derivatives, and evaluated their inhibitory potency against MAOs, AChE, BuChE by in vitro enzyme effect assays. Based on activity results, we found that derivatives N-(5-methylbenzo[d]thiazol-2-yl)-3-(pyrrolidin-1-yl)propanamide (2 c) and N-(6-bromobenzo[d]thiazol-2-yl)-3-(pyrrolidin-1-yl)propanamide (2 h) showed good inhibitory potency against BuChE with IC values of 15.12 μM and 12.

Evaluation of water quality and its driving forces in the Shaying River Basin with the grey relational analysis based on combination weighting.

The water quality of the Shaying River Basin and even the entire Huai River Basin has been widely concerned. Based on the water quality data acquired in flood and non-flood seasons from 2012 to 2016, the Shaying River Basin was selected as the research object. First, the principal component analysis method was used to identify the main pollution indices.