Pathological changes at early stage of multiple organ injury in a rat model of severe acute pancreatitis.

Background: Severe acute pancreatitis (SAP) is a commonly seen acute abdominal syndrome characterized by sudden onset, rapid progression and high mortality rate. The damage in peripheral organs may be more severe than that in the pancreas, and can even lead to multiple organ dysfunction. It is critical to recognize early pathological changes in multiple organs.

Preparation method of an ideal model of multiple organ injury of rat with severe acute pancreatitis.

Aim: To establish an ideal model of multiple organ injury of rats with severe acute pancreatitis (SAP).

Methods: SAP models were induced by retrograde injection of 0.1 mL/100 g 3.