Publications by authors named "Xin-Feng Yang"
Endophytic fungi from medicinal plants with specific pharmacological functions attract much attention to provide the possibility of discovering valuable natural drugs with novel structures and biological activities. is a rare and endangered karst endemic plant that is used as medicine and food homology in Guangxi, China. These plants have been reported to have antimicrobial, antitumor, antiviral, and anti-inflammatory activities.
View Article and Find Full Text PDF[Genetic diversity and antibacterial activity of endophytic fungi from Zanthoxylum nitidum].
Zhongguo Zhong Yao Za Zhi
July 2021
Article Synopsis
- This study investigates the distribution and antibacterial potential of endophytic fungi from the Zanthoxylum nitidum plant in Guangxi, identifying genetic diversity through molecular methods.
- Researchers isolated 35 fungal strains from various plant tissues, with Colletotrichum and Fusarium being the dominant genera, and found significant differences in fungal diversity among roots, stems, and leaves.
- The antimicrobial activity analysis revealed that 14.28% of the isolated fungi inhibited bacteria, particularly Fusarium sp. ZN-34 and ZN-26, which showed strong effects against Escherichia coli and Staphylococcus aureus, indicating potential for developing natural antibacterial agents.
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is activated by the neuron-specific activators p35/p39 and plays important roles in neuronal development, synaptic plasticity, and cognitive behavior. However, the proteolytic cleavage of p35 to p25 leads to prolonged and aberrant Cdk5 activation and results in synaptic depression, highly mimicking the early pathology of Alzheimer's disease (AD). Therefore, Cdk5 inhibition is a potential promising strategy for AD drug development.
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