The Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression.

Enhanced nucleoside metabolism is one of the hallmarks of cancer. Uridine-cytidine kinase 2 (UCK2) is a rate-limiting enzyme of the pyrimidine salvage synthesis pathway to phosphorylate uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively. Recent studies have shown that UCK2 is overexpressed in many types of solid and hematopoietic cancers, closely associates with poor prognosis, and promotes cell proliferation and migration in lung cancer and HCCs.

The Therapeutic Effects of Acupuncture and Electroacupuncture on Cancer-related Symptoms and Side-Effects.

In addition to cancer-related death, malignant progression also leads to a series of symptoms and side-effects, which would detrimentally affect cancer patients' the quality of life, adversely influence their adherence to treatments, and, therefore, negatively affect their long-term survival. Acupuncture and electroacupuncture (EA), as two classic treatment methods in traditional Chinese medicine, have been widely employed to cure various diseases. Recently, the clinical application of acupuncture and EA in cancer patients has received great attention.

Circular RNAs and Hepatocellular Carcinoma: New Epigenetic Players With Diagnostic and Prognostic Roles.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Due to the lack of potent diagnosis and prognosis biomarkers and effective therapeutic targets, the overall prognosis of survival is poor in HCC patients. Circular RNAs (circRNAs) are a class of novel endogenous non-coding RNAs with covalently closed loop structures and implicated in diverse physiological processes and pathological diseases.

Southerners Are Wiser Than Northerners Regarding Interpersonal Conflicts in China.

Initial evidence suggests that cultural differences have consequences for wise reasoning (perspective taking, consideration of change and alternatives, intellectual humility, search for compromise, and adopting an outsider's vantage point), with more reports of wise reasoning about interpersonal conflicts among Japanese (as compared to American) young and middle-aged adults. Similarly, we found that people from the rice-farming area of southern China also exhibited greater wise reasoning when they encountered conflicts with a friend or in the workplace than those from the wheat-farming area of northern China ( = 487, 25 provinces). The relationship between rice farming and wise reasoning was mediated by loyalty/nepotism.

Asparagus polysaccharide and gum with hepatic artery embolization induces tumor growth and inhibits angiogenesis in an orthotopic hepatocellular carcinoma model.

Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties.

[Water impounding characteristics of bamboo-shaped rainwater harvesting ditch in the hilly loess region].

Bamboo-shaped rainwater harvesting ditch (BRHD) is a new water harvesting and application technology being promoted in the hilly loess region of North Shannxi Province. This paper measured the soil moisture condition and water storage capacity of BRHDs filled with straw, branch or gravel through field and simulated rainfall experiments to evaluate the water holding and absorption capacity of different BRHD fillers. From May to October, the water storage of BRHDs showed a decrease trend at first and then increased in field experiment.

[Methodological study on calibrating and validating model parameters of MUCT processes at low C/N ratio].

Basing on ASM2d, established a mathematical model to describe the transformation of COD, TN, NH4(+)-N and TP. In terms of comparison between simulation and observed values, the kinetics and stoichiometric parameters were established in MUCT process treating a wastewater with low C/N ratio. The results showed that, the q(PHA), K(A), K(pp), Y(PO4(3-), micro(AUT) and eta(NO3(-) were 2.