Publications by authors named "Xin-Chun Zhao"
Article Synopsis
- The study investigates how the EGFR oncoprotein avoids degradation in non-small cell lung cancer (NSCLC) by systematically analyzing ubiquitin pathway genes (UPGs) and their role in the disease.
- Using a library of small interfering RNA (siRNA) to silence 696 UPGs in NSCLC cells, the researchers identified 31 significant candidates, with the E2 enzyme CDC34 being the most critical for cancer cell proliferation.
- Elevated levels of CDC34 in tumor tissues were linked to poorer prognosis and increased cell proliferation, making it a promising target for developing new treatments for NSCLC.
Whether tobacco carcinogens enable exposed cells immune escape resulting in carcinogenesis, and why patients who smoke respond better to immunotherapies than non-smokers, remains poorly understood. Here we report that cigarette smoke and the carcinogen benzo(a)pyrene (BaP) induce PD-L1 expression on lung epithelial cells in vitro and in vivo, which is mediated by aryl hydrocarbon receptor (AhR). Anti-PD-L1 antibody or deficiency in AhR significantly suppresses BaP-induced lung cancer.
View Article and Find Full Text PDFRed wine consists of a large amount of compounds such as resveratrol, which exhibits chemopreventive and therapeutic effects against several types of cancers by targeting cancer driver molecules. In this study, we tested the anti-lung cancer activity of 11 red wine components and reported that a natural polyphenol compound ellagic acid (EA) inhibited lung cancer cell proliferation at an efficacy approximately equal to that of resveratrol. EA markedly increased the expression of the autophagosomal marker LC3-II as well as inactivation of the mechanistic target of rapamycin signalling pathway.
View Article and Find Full Text PDFArticle Synopsis
- A genome-wide screening of 1530 transcription factors (TFs) in non-small cell lung cancer (NSCLC) cells identified 21 essential TFs linked to cancer cell growth and patient survival.
- Among these, 11 are proposed tumor suppressors and 10 are potential oncogenes, with notable figures like PTEN and IRX5 highlighted.
- The study found that tobacco carcinogen benzo(a)pyrene increases IRX5 levels, which in turn influences tumor growth, suggesting that targeting IRX5 could be a promising therapy in NSCLC treatment.
Indoor and outdoor air pollution has been classified as group I carcinogen in humans, but the underlying tumorigenesis remains unclear. Here, we screened for abnormal long noncoding RNAs (lncRNAs) in lung cancers from patients living in Xuanwei city which has the highest lung cancer incidence in China due to smoky coal combustion-generated air pollution. We reported that Xuanwei patients had much more dysregulated lncRNAs than patients from control regions where smoky coal was not used.
View Article and Find Full Text PDFBackground: The aim of the present study is to evaluate the effectiveness of the combined application of high-intensity focused ultrasound (HIFU) and radiotherapy in the treatment of locally advanced pancreatic carcinoma (LAPC).
Methods: A total number of sixteen patients with LAPC started treatment beginning with HIFU and radiotherapy 1 week after the HIFU treatment. Evaluation of the effectiveness of treatment was performed using main clinical symptoms, serum levels of CA-19-9, Response Evaluation Criteria in Solid Tumors (RECIST) guidelines, and the Kaplan-Meier method for estimating median overall survival (OS).