Publications by authors named "Xin-Chun Ye"
Article Synopsis
- The study aimed to analyze the clinical characteristics and trends of human leptospirosis in Wenzhou, China, from 2020 to 2022 to better inform prevention and control measures.
- A total of 41 cases were reported during this period, with the highest incidence in 2021 and a notable concentration of cases occurring in the late summer to fall, primarily affecting males in the farming sector.
- The findings indicate a moderate level of leptospirosis incidence, emphasizing the need for improved monitoring of host animals and populations to prevent future outbreaks.
The study analyzes the risk factors associated with antituberculosis drug-induced liver injury (ATB-DILI), and the relationship between ATB-DILI and gene polymorphisms. Out of the 324 included patients, 57 (17.59%) developed ATB-DILI.
View Article and Find Full Text PDFConsidering the genetic characteristics of people with anti-tuberculosis (TB)-drug-induced liver injury (ATDILI), genetic factors and their consequences for treatment need to be studied. The correlation between N-acetyltransferase 2 (NAT2) genetic polymorphisms and ATDILI was analysed. In this study, the liver and coagulation functions of 120 patients with TB were monitored dynamically for at least 3 months.
View Article and Find Full Text PDFIschemia-induced neuronal death leads to serious lifelong neurological deficits in ischemic stroke patients. Histone deacetylase 6 (HDAC6) is a promising target for neuroprotection in many neurological disorders, including ischemic stroke. However, the mechanism by which HDAC6 inhibition protects neurons after ischemic stroke remains unclear.
View Article and Find Full Text PDFThe methyltransferase-like 3 (Mettl3) is a key component of the large N6-adenosine-methyltransferase complex in mammalian responsible for RNA N6-methyladenosine (m6A) modification, which plays an important role in gene post-transcription modulation. Although RNA m6A is enriched in mammalian neurons, its regulatory function in nociceptive information processing remains elusive. Here, we reported that Complete Freund's Adjuvant (CFA)-induced inflammatory pain significantly decreased global m6A level and m6A writer Mettl3 in the spinal cord.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the clinical features of 105 COVID-19 patients outside of Wuhan, identifying their travel history and transmission chains between generations of infections.
- Among the patients, 52% had recently traveled to Wuhan, and 36% could trace their infection back to close contact with someone from there, establishing a pattern of first-, second-, and third-generation cases.
- The conclusion emphasizes the importance of early diagnosis and treatment for COVID-19 symptoms to improve patient outcomes, especially for those at high risk of complications.*
Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice.
J Neuroinflammation
January 2020
Background: Dendritic cell-associated C-type lectin-1 (Dectin-1) receptor has been reported to be involved in neuroinflammation in Alzheimer's disease and traumatic brain injury. The present study was designed to investigate the role of Dectin-1 and its downstream target spleen tyrosine kinase (Syk) in early brain injury after ischemic stroke using a focal cortex ischemic stroke model.
Methods: Adult male C57BL/6 J mice were subjected to a cerebral focal ischemia model of ischemic stroke.
Background And Purpose: Lrp4 (low-density lipoprotein receptor-related protein 4) is predominantly expressed in astrocytes, where it regulates glutamatergic neurotransmission by suppressing ATP release. Here, we investigated Lrp4's function in ischemia/stroke-induced brain injury response, which includes glutamate-induced neuronal death and reactive astrogliosis.
Methods: The brain-specific Lrp4 conditional knockout mice (Lrp4), astrocytic-specific Lrp4 conditional knockout mice (Lrp4), and their control mice (Lrp4) were subjected to photothrombotic ischemia and the transient middle cerebral artery occlusion.