Publications by authors named "Xin-Chao Zhu"
Article Synopsis
- The study aimed to analyze DNA methylation profiles in the blood of patients with Sjögren syndrome and healthy controls to understand how certain genes contribute to the disease's progression.
- Researchers performed whole-genome bisulfite sequencing and conducted various analyses to identify differentially methylated regions (DMRs) and their biological significance.
- They discovered 322 DMRs linked to 162 genes, with certain genes like HLA class I, ADAR, and OAS2 showing differential expression, suggesting they could serve as potential biomarkers for diagnosing Sjögren syndrome and may inform future treatments.
Circulating microRNAs (miRNAs) have proved to be promising biomarkers for early diagnosis and therapeutic monitoring in cancers. Particularly for hepatocellular carcinoma (HCC), detection of circulating miRNA biomarkers as a new diagnostic approach has been written into the latest Guidelines for Diagnosis and Treatment of Primary Liver Cancer in China (2019 edition). However, no general consensus on an ideal endogenous normalizer for circulating miRNAs quantification has been reached, so it will affect the accuracy of quantitative results.
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