Intermittent fasting inhibits platelet activation and thrombosis through the intestinal metabolite indole-3-propionate.

Platelet hyperreactivity contributes significantly to thrombosis in acute myocardial infarction and stroke. While antiplatelet drugs are used, residual ischemic risk remains. Intermittent fasting (IF), a dietary pattern characterized by alternating periods of eating and fasting, has shown cardiovascular benefits, but its effect on platelet activation is unclear.

The impact of family socioeconomic status on adolescent mental and physical health: the mediating role of parental involvement in youth sports.

Introduction: The physical and mental health of adolescents is a crucial cornerstone for social development. Therefore, this study aimed to examine whether family socioeconomic status made a difference in Chinese teenage mental and physical health and to disentangle the mediating role of parental involvement in youth sports in the process in which family socioeconomic status influenced adolescent health.

Methods: A quantitative analysis used a sample of approximately 11,000 adolescents from Chinese middle schools.

The effectiveness of individualized blood flow restriction training following patellar fracture surgery: a case series.

Background: Patellar fracture surgeries are associated with subsequent atrophy and weakness in the muscles of the lower limb. Individualized blood flow restriction training is progressively being recognized as a potential technique for improving muscular hypertrophy and accompanying strength in participants recovering from surgery. This study aimed to investigate the overall feasibility and observational outcomes of individualized blood flow restriction training for participants recovering from patellar fracture surgery.

Highly Adhesive ZJ316: Structural Insights of Lipoteichoic Acid and Its Anti-Inflammatory Properties.

Lactic acid bacteria are widely recognized for their probiotic properties, and their adhesion to the gastrointestinal tract is a prerequisite for their probiotic functions. This investigation aimed to screen a highly adherent strain and explore the impact of its surface lipoteichoic acid (LTA) on strain adhesion to intestinal epithelial cells and the immunomodulatory activity. Results demonstrated that ZJ316 exhibited remarkable surface properties and superior adhesion to enterocytes, and the fluorescent labeling revealed that ZJ316 predominantly adhered to the cecum in mice.

Photothermal and Hydrophobic Surfaces with Nano-Micro Structure: Fabrication and Their Anti-Icing Properties.

The formation of ice due to global climate change poses challenges across multiple industries. Traditional anti-icing technologies often suffer from low efficiency, high energy consumption, and environmental pollution. Photothermal and hydrophobic surfaces with nano-micro structures (PHS-NMSs) offer innovative solutions to these challenges due to their exceptional optical absorption, heat conversion capabilities, and unique surface water hydrophobic characteristics.

Preoperative SII Can Predict Postoperative Recurrence and Serious Complications in Patients with Hepatolithiasis.

Purpose: The occurrence and progression of hepatolithiasis are related to inflammatory reactions and immune proteins. This study aims to evaluate the relationship between systemic immune index (SII) in recurrence-free survival (RFS), as well as the incidence of severe postoperative complications in hepatolithiasis patients.

Patients And Methods: We retrospectively analyzed 177 patients with hepatolithiasis.

Two-Dimensional Heteropore Covalent Organic Frameworks: From Construction to Functions.

ConspectusCovalent organic frameworks (COFs) represent a fascinating class of crystalline porous polymers constructed from organic building blocks linked by covalent bonds. Benefiting from their high crystallinity, large surface area, and ease of functionalization, COFs have demonstrated significant potential across various fields, including gas adsorption, luminescence, sensing, catalysis, energy storage, nanomedicine, etc. In the first decade of COF development, only those with homogeneous porosity have been constructed, and thus, their topological structures are quite limited.

Recent advances and future directions in urinary system tissue engineering.

Recent advancements in tissue engineering offer promising solutions for the repair and reconstruction of the urinary system, particularly in cases of urinary organ injuries. Historically, autologous tissue grafts and allografts have been the primary options for repairing damaged tissues. However, these approaches often lead to complications such as immune rejection, donor site morbidity, and functional limitations.

Enhancing cybersecurity through script development using machine and deep learning for advanced threat mitigation.

This scholarly paper explores the utilization of Machine Learning (ML) and Deep Learning (DL) methodologies to enhance the cybersecurity aspects of script development. Given the increasing panorama of threats in contemporary software creation, cybersecurity has ascended to a critical realm of concern. Traditional security measures frequently prove inadequate in countering complex breaches.

Engineering fluorescent carbon dot sensor with rare earth europium for the detection of uranium (VI) ion in vivo.

Three types of carbon dots were synthesized using the same precursor (folic acid and europium nitrate) via different preparation methods (doping and direct coordination). A comprehensive comparison and analysis of the morphology, surface groups, and optical properties of the prepared carbon dots (CD), europium-doped carbon dots (CD-Eu), and europium-functionalized carbon dots (CD@Eu) were conducted. Moreover, due to the higher quantum yield, excellent stability, and outstanding selectivity for UO exhibited by CD-Eu, we selected CD-Eu as the probe for subsequent applications.

Bioinspired Durable Daytime Radiative Cooling Wood: Realizing Outdoor Longtime Use.

Daytime radiative cooling dissipates heat from surfaces by reflecting sunlight and emitting infrared radiation to outer space, featuring zero-energy consumption. Wood-based coolers have received more attention due to their high infrared emissivity, sustainability, and low cost. However, they often degrade under ultraviolet (UV) radiation exposure, resulting in a poor cooling efficiency.

Pressure-Assisted Anisotropy in Carbon Nanofiber Films for Smart Electromagnetic Interference Shielding and Joule Heating.

Intelligent electromagnetic interference (EMI) shielding materials with adjustable properties and performances are garnering significant attention due to the escalating complexity of application scenarios for electronic devices. Also, the trend of miniaturization is calling for lightweight and multifunctional materials. Here, the preparation of highly aligned carbon nanofiber film (a-CNFF) by electrospinning technology and a two-stage carbonization process is proposed, in which the pressurization strategy in the carbonization process promotes the development of highly aligned fiber network structures.

A small-scale data driven and graph neural network based toxicity prediction method of compounds.

Toxicity prediction is crucial in drug discovery, helping identify safe compounds and reduce development risks. However, the lack of known toxicity data for most compounds is a major challenge. Recently, data-driven models have gained attention as a more efficient alternative to traditional in vivo and in vitro experiments.

Application of autologous platelet rich plasma in Sun's procedure for acute type A aortic dissection under moderate hypothermia.

Background: Coagulopathy and inflammatory response are the intractable complication during Sun's procedure for type A aortic dissection (AAD). This study aims to investigate the efficacy of autologous platelet rich plasma (aPRP) on the patients undergoing Sun's procedure under moderate hypothermia.

Methods: A total of 372 AAD patients who underwent Sun's procedure under moderate hypothermia were divided into aPRP group (aPRP was separated before heparinization and transfused after protamine neutralization) and Non-aPRP group (without aPRP apheresis).

A high-throughput anaerobic method for viability assays.

Unlabelled: Viability testing for anaerobes is a time-consuming and expensive process, posing challenges for research and public health settings. Here, we present a rapid, economical, and reliable method for testing anaerobe viability using the Geometric Viability Assay (GVA) with as our model, a bacterium known for causing toxin-related systemic and enteric diseases. This method is efficient and cost-effective, requiring one pipette tip per sample, and is compatible with the economical anaerobic jar system.

LncRNA MALAT1/Calpain-1 Axis in ATO Induced hERG Channel Deficiency.

Background: KCNH2 encodes the hERG potassium channel, which is associated with drug-induced long QT syndrome. Arsenic trioxide (ATO) is an effective therapeutic agent for acute promyelocytic leukemia; however, its long-term use can lead to cardiotoxicity, particularly in cases of acquired long QT syndrome (acLQTS), which may result in torsade de pointes (TdP). Therefore, it is essential to comprehend the mechanisms behind acLQTS and to develop effective preventive and therapeutic strategies.

Heterostructured Electrocatalysts: from Fundamental Microkinetic Model to Electron Configuration and Interfacial Reactive Microenvironment.

Electrocatalysts can efficiently convert earth-abundant simple molecules into high-value-added products. In this context, heterostructures, which are largely determined by the interface, have emerged as a pivotal architecture for enhancing the activity of electrocatalysts. In this review, the atomistic understanding of heterostructured electrocatalysts is considered, focusing on the reaction kinetic rate and electron configuration, gained from both empirical studies and theoretical models.

Short-term social isolation acts on hypothalamic neurons to promote social behavior in a sex- and context-dependent manner.

Social animals, including both humans and mice, are highly motivated to engage in social interactions. Short-term social isolation promotes social behavior, but the neural circuits through which it does so remain incompletely understood. Here, we sought to identify neurons that promote social behavior in single-housed female mice, which exhibit increased rates of social investigation, social ultrasonic vocalizations (USVs), and mounting during same-sex interactions that follow a period of short-term (3 days) isolation.

Functionalized zeolite regulates bone metabolic microenvironment.

The regulation of bone metabolic microenvironment imbalances in diseases such as osteoporosis, bone defects, infections, and tumors remains a significant challenge in orthopedics. Therefore, it has become urgent to develop biomaterials with effective bone metabolic microenvironmental regulatory functions. Zeolites, as advanced biomedical materials, possess distinctive physicochemical properties such as multi-level pore structures, adjustable frameworks, easily modifiable surfaces, and excellent adsorption capabilities.

3D printing in musculoskeletal interface engineering: Current progress and future directions.

The musculoskeletal system relies on critical tissue interfaces for its function; however, these interfaces are often compromised by injuries and diseases. Restoration of these interfaces is complex by nature which renders traditional treatments inadequate. An emerging solution is three-dimensional printing, which allows for precise fabrication of biomimetic scaffolds to enhance tissue regeneration.

Nature-derived microneedles with metal-polyphenolic networks encapsulation for chronic soft tissue defects repair: Responding and remodeling the regenerative microenvironment.

The treatment outcomes of traditional patches for chronic soft tissue defects (CSTDs) are unsatisfactory in clinical, owing to the lack of intrinsic bioactivities to orchestrate the intricate regenerative process. To tackle this deficiency, nature-derived microneedles (NMs) composed of silk methacrylate and snail mucus are developed in this study. The resultant NMs have excellent mechanical strength and biological adhesiveness, ensuring suture-free but reliable fixation on implanted site.

Preclinical application of a CD155 targeting chimeric antigen receptor T cell therapy for digestive system cancers.

Despite intensive multimodal therapy, the prognosis for patients with digestive system cancers remains poor. Cancer cell heterogeneity and immunosuppressive microenvironments are the main barriers to the effective CAR-T cell therapy with solid malignancies. In parallel, tumor-associated macrophages (TAMs) are essential for tumor immunosuppressive microenvironment formation.

Neuroinflammation and pathways that contribute to tourette syndrome.

Tourette syndrome (TS), a neurological and psychological disease, typically exhibit motor and phonic tics. The pathophysiology of TS remains controversial. Currently, the recognized pathogenesis of TS is the imbalance of neurotransmitters, involving abnormality of the cortex-striatum-thalamus-cortex circuit.

COS-DeformDeep: Adaptive 2T2D spectral feature extraction method for improving the component identification performance in mixtures based on handheld Raman technology.

Background: Raman spectroscopy is extensively utilized for the analysis of mixture components. Handheld Raman spectrometers, characterized by their compactness and portability, can rapidly acquire on-site spectral data without the need for intricate pretreatment or bulky instrumentation. In comparison to traditional laboratory-grade spectrometers, handheld devices offer distinct advantages.