Publications by authors named "Xin Z Yu"
Article Synopsis
- The study focuses on primary gallbladder neuroendocrine carcinomas (GB-NEC), aiming to summarize their characteristics, effective treatments, and factors affecting patient prognosis.
- A total of 55 patients who underwent surgical resection were analyzed, revealing that those who had R resection had significantly better overall survival than others.
- Key factors associated with reduced survival included being 60 years or older, having carcinoid syndrome, and undergoing non-R resection, emphasizing the importance of complete surgical removal as the primary treatment approach.
Here, we describe the generation and characterization of a novel tau transgenic mouse model (mTau) that overexpresses wild-type murine tau protein by twofold compared with endogenous levels. Transgenic tau expression was driven by a BAC transgene containing the entire wild-type mouse tau locus, including the endogenous promoter and the regulatory elements associated with the tau gene. The mTau model therefore differs from other tau models in that regulation of the genomic mouse transgene mimics that of the endogenous gene, including normal exon splicing regulation.
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