Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade.

Background: Periprosthetic osteolysis and subsequent aseptic loosening are the leading causes of failure following total joint arthroplasty. Osteogenic impairment induced by wear particles is regarded as a crucial contributing factor in the development of osteolysis, with endoplasmic reticulum (ER) stress identified as a key underlying mechanism. Therefore, identifying potential therapeutic targets and agents that can regulate ER stress adaption in osteoblasts is necessary for arresting aseptic loosening.

Halogenated bisphenol F compounds: Chlorination-mediated formation and photochemical fate in sunlit surface water.

Halogenated bisphenol compounds are prevalent in urban water systems and may pose greater environmental risks than their bisphenol precursors. This study explored the formation of halogenated bisphenol F (BPF) in water chlorination and their subsequent transformation behaviors in receiving waters. The kinetics and pathways of BPF halogenation with chlorine, bromine, and iodine were firstly investigated.

A novel dicyanoisophorone-based fluorescent probe for rapid detection of acetylcholinesterase in biological systems.

Acetylcholinesterase (AChE) plays a vital role in various neurological diseases including brain disorders, neurotransmission alterations, and cancer. Developing effective methods to image AChE in biological samples is essential for understanding its mechanisms in biosystems. Here, we introduce a novel fluorescent probe CNA, that enables detection of AChE at 520 nm with rapid response time of 60 s and a detection limit of 0.

Analysis of tumor treatment under interventional ultrasound through structural and temporal dynamics: a bibliometric visualization.

Background: Ultrasound is considered one of the most crucial tools for image-guided tumor ablation, and provides a vital alternative approach to tumor treatment. This study used bibliometric methods to characterize the development history of tumor treatment under interventional ultrasound and explore future research hotspots.

Methods: In this study, we retrieved and selected publications on tumor treatment under interventional ultrasound from the Web of Science Core Collection (WoSCC) database published from 1960 to 2023.

Unraveling the causal relationship between serum minerals and pancreatic cancer: a Mendelian randomization study.

Background: Pancreatic cancer is among the most lethal malignancies, characterized by a poor prognosis and limited modifiable factors. Emerging evidence indicates that serum mineral levels may influence the likelihood of developing pancreatic cancer. However, the causal relationship between serum minerals and pancreatic cancer remains unclear and warrants further investigation.

Thrombotic Microangiopathy Associated with Calcineurin Inhibitors: A Real-World Analysis of Postmarketing Surveillance Data.

Purpose: Calcineurin inhibitors (CNIs) are currently the first-line drugs for preventing and treating post-transplant rejection in organ transplant recipients. However, these drugs, especially tacrolimus, have the potential to induce thrombotic microangiopathy (TMA), a rare but potentially fatal complication that can develop following transplantation. This condition has garnered considerable attention within the medical community.

Development of a RIPK1 degrader to enhance antitumor immunity.

The scaffolding function of receptor interacting protein kinase 1 (RIPK1) confers intrinsic and extrinsic resistance to immune checkpoint blockades (ICBs) and emerges as a promising target for improving cancer immunotherapies. To address the challenge posed by a poorly defined binding pocket within the intermediate domain of RIPK1, here we harness proteolysis targeting chimera (PROTAC) technology to develop a RIPK1 degrader, LD4172. LD4172 exhibits potent and selective RIPK1 degradation both in vitro and in vivo.

A Multi-centre Analysis of Serum IgE Levels in Atopic Dermatitis.

Objective: To assess the characteristics of total immunoglobulin E (IgE) and allergen-specific IgE (sIgE) to 20 common allergens in 154 patients with atopic dermatitis (AD). To assess the correlation of clinical food allergy with positive food allergens' sIgE results. We further discuss the significance of IgE as a potential biomarker for AD disease severity.

Sulfur metabolism and response to light in Ulva prolifera green tides.

The outbreak of Ulva prolifera blooms causes significant changes in the coastal sulfur cycle due to the high production of dimethylsulfoniopropionate (DMSP) and the emission of dimethylsulfide (DMS). However, the sulfur metabolism mechanism of U. prolifera has not been thoroughly investigated.

Cyanobacteria in late lag and exponential phases suit different pre-chlorination and coagulation strategies.

Pre-chlorination is usually applied to facilitate coagulation process when treating cyanobacteria-laden source waters. However, the responses of cyanobacteria after chlorination were varied in different growth phases, hence how these differences affect the coagulation is not clear. In this study, Microcystis aeruginosa (M.

Association Between Peptide Antigen-Related Antibody Levels and the Short- and Long-Term Efficacy of Antipsychotic Treatment in Drug-Naïve First-Episode Schizophrenia Patients.

Objective: This study investigated the relationships between baseline peptide antigen-related IgG levels and 8-week antipsychotic drug (APD) treatment response rates and one-year treatment outcomes, as well as the relationships between changes in peptide antigen-related IgG levels and one-year treatment outcomes, in first-episode schizophrenia (FES) patients.

Methods: Sixteen peptide antigen-related IgGs from proteins encoded by schizophrenia-related genes were selected on the basis of several selection criteria from a 2022 genome-wide association study. Novel peptide antigen-related IgG levels were measured in drug-naïve FES patients at baseline (n = 155) and in plasma samples from 60 healthy controls (HCs).

Enhancing Ion Selectivity of Nanofiltration Membranes via Heterogeneous Charge Distribution.

Nanofiltration technology holds significant potential for precisely separating monovalent and multivalent ions, such as lithium (Li) and magnesium (Mg) ions, during lithium extraction from salt lakes. This study bridges a crucial gap in understanding the impact of the membrane spatial charge distribution on ion-selective separation. We developed two types of mixed-charge membranes with similar pore sizes but distinct longitudinal and horizontal distributions of oppositely charged domains.

Advances in antitumor effects of pterostilbene and its derivatives.

Pterostilbene (PT) is a naturally occurring small molecule stilbenoid that has garnered significant attention due to its potential therapeutic effects in tumor diseases. In this review, we conducted a comprehensive analysis of the antitumor effects of PT and its derivatives on various cancer types, including colon, breast, liver, lung, and pancreatic cancers in recent 20 years. We have succinctly summarized the PT derivatives that exhibit superior anti-tumor efficacy compared to PT.

An integrative taxonomy of some close related Palaearctic Macromia spp. (Anisoptera: Macromiidae).

An integrative taxonomy combining morphological and molecular data confirmed that both Macromia amphigena Selys, 1871 and M. manchurica Asahina, 1964 have been assigned to separate species hypotheses, although there is hybridization between the members of these taxa. Scientific names Macromia clio Ris, 1916 and Macromia kubokaiya Asahina, 1964 are shown to be junior synonyms of M.

A xanthene-based fluorescent probe capable of selectively detecting phosgene in living mouse model.

In this study, we introduced a novel fluorescent probe RNP, which demonstrated outstanding sensitivity and specificity for phosgene detection. Upon phosgene exposure, the probe exhibited rapid fluorescence turn-on within a short re-sponse time (6 s). RNP was also effective in both cellular and murine experiments, where fluorescence enhancement was observed in the respiratory tract of mice.

High-dimensional anticounterfeiting nanodiamonds authenticated with deep metric learning.

Physical unclonable function labels have emerged as a promising candidate for achieving unbreakable anticounterfeiting. Despite their significant progress, two challenges for developing practical physical unclonable function systems remain, namely 1) fairly few high-dimensional encoded labels with excellent material properties, and 2) existing authentication methods with poor noise tolerance or inapplicability to unseen labels. Herein, we employ the linear polarization modulation of randomly distributed fluorescent nanodiamonds to demonstrate, for the first time, three-dimensional encoding for diamond-based labels.

Integrated inactivation of Microcystis aeruginosa and degradation of microcystin-LR by direct current glow discharge plasma in liquid-phase: Mechanisms and cell deactivation process.

The frequent occurrence of blooms of Microcystis aeruginosa (M. aeruginosa) and the subsequent release of microcystin-LR (MC-LR) in eutrophic waters pose a serious threat to aquatic ecosystems. This study investigated the optimal conditions for inactivating M.

Effect of Resveratrol on the intestinal microbiota in Type2 diabetes Mellitus mice.

Some natural products have been found to have a positive effect on the treatment of Type 2 Diabetes Mellitus (T2DM). The effective mechanism by which these natural products work may be attributed to their ability to alter the gut microbiome. In this study, considering the beneficial properties of resveratrol for T2DM, the mechanism of resveratrol in releasing of T2DM, the correlation between the apparent traits of resveratrol in T2DM mice and the changes in intestinal flora structure were explored.

Innovations in radiotherapy for tongue squamous cell carcinoma.

Radiotherapy sensitivity is associated with the prognosis of patients with tongue squamous cell carcinoma (TSCC). In the present study, we proposed to explore the specific mechanism of interventional radiology (IR) therapy for TSCC in vitro and in vivo. TSCC cells were treated with 6 Gy IR and tumor bearing mice were treated with 20 Gy × 1 IR.

Uniportal Robotic Lobectomy and Lymphadenectomy for Invasive Lung Cancer: A Novel Approach and Perioperative Outcomes.

Background: Multiport robot-assisted thoracoscopic surgery (mRATS) has been comprehensively evaluated for its clinical efficacy in numerous studies. Nevertheless, the safety and feasibility of uniportal robotic lobectomy and lymphadenectomy require further validation.

Methods: The clinical data of 34 consecutive patients with lung cancer who underwent improved uniportal robotic-assisted thoracoscopic surgery (uRATS) at our hospital between November 2023 and June 2024 were reviewed retrospectively.

High temperatures promote antibiotic resistance genes conjugative transfer under residual chlorine: Mechanisms and risks.

The impact of residual chlorine on the dissemination of antibiotic resistance during the distribution and storage of water has become a critical concern. However, the influence of rising temperatures attributed to global warming on this process remains ambiguous, warranting further investigation. This study investigated the effects of different temperatures (17, 27, 37, and 42°C) on the conjugative transfer of antibiotic resistance genes (ARGs) under residual chlorine (0, 0.

Decoupled tip-tilt detection and steering of beamlets in a fiber laser array using sequential tagging lasers.

The tiled fiber laser array is a promising architecture for power scaling and mitigation of atmospheric turbulence. Precise tip-tilt detection and steering of the beamlets in the array to guarantee effective overlap in the far-field is essential for high beam qualities. However, the beamlets are tightly coupled in the far-field, making it a major challenge to identify each other.