Publications by authors named "Xin Yong Luan"

Objective: To explore the surgical methods for advanced laryngeal cancer and long term effects of laryngectomy.

Methods: Two hundred and thirty-eight cases of laryngeal cancer at different stages, including 103 cases with supraglottic cancer, 118 cases with glottic cancer, 3 cases with subglottic cancer, and 14 cases with recurrent cancer, underwent different kinds of operation from 2000 to 2010. The TNM classifications were as follows: T3 168 cases, T4 70 cases.

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Objective: To detect lymphangiogenesis by labeling the lymphatic endothelial marker, lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), and study the prognostic relevance of lymphangiogenesis in laryngeal squamous carcinoma.

Methods: Clinical files and specimens of 78 patients with histologically diagnosed laryngeal carcinoma were stained with LYVE-1 as a specific lymphatic endothelial marker. The lymphatic vessel density (LVD) was measured, and the correlation between LVD and clinicopathological features of the tumor cases was analyzed.

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Objective: To review the experience of different surgical construction methods and comprehensive treatments for hypopharyngeal cancer.

Methods: Three hundred and fifty-two cases (According to UICC 2002 criteria, stage I, 3; II, 31; III, 134; IV, 184) with hypopharyngeal cancer were retrospectively reviewed from 1999 to 2005 in the Department of Otorhinolaryngology of Qilu Hospital of Shandong University, including 321 males and 31 females. The median age was 58 years old, ranged from 26 to 82 years old.

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Article Synopsis
  • Surgical resection of laryngeal squamous cell carcinoma (LSCC) may enhance the number and function of certain types of immune cells called dendritic cells in patients.
  • The study involved 46 LSCC patients and 15 healthy controls, using blood samples and flow cytometry to assess the immune response before and after treatment.
  • While surgery improved some immune markers in both surgical and radiation patients, full recovery of immune function was only seen in those who had surgery without adjunctive radiotherapy.
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Purpose: The aim of this study was to evaluate the suppression effect of survivin shRNA on the expression of the survivin gene in the human laryngeal cancer cell line Hep-2.

Procedures: 60 cases of laryngeal squamous-cell carcinoma (LSCC) and 10 cases of normal laryngeal mucosa were examined using immunohistochemistry to determine whether the expression of survivin correlated with tumorigenesis. Three plasmid vectors of short hairpin RNA (shRNA) specific for survivin were designed and generated.

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Objective: To explore the methods of surgical treatment and preservation of laryngeal function in senile patients with advanced laryngeal carcinoma.

Methods: A retrospective data review of 87 advanced laryngeal carcinoma patients aged over 65 years was carried out. Of these 87 patients treated by different modes of surgery, 48 had supraglottic cancer, 35 glottic cancer and 4 subglottic cancer.

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Background & Objective: The prolongation of life expectancy results in an increasing number of aged patients with hypopharyngeal carcinoma who have poor surgical tolerance because of degenerative organ functions. This study was to explore the surgical methods and preservation of laryngeal function for aged patients with hypopharyngeal carcinoma.

Methods: Clinical data of 84 patients with hypopharyngeal carcinoma who aged above 60 years, treated from 1996 to 2001, were retrospectively reviewed.

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Objective: To review the experience of different surgical construction methods for hypopharyngeal cancer with cervical esophageal invasion.

Methods: From 1989 to 2000,forty-eight patients with advanced hypopharyngeal cancer and cervical esophageal invasion were retrospectively reviewed, including 38 males and 10 females. The median age was 54.

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Article Synopsis
  • The study investigates surgical techniques for treating postcricoid carcinoma in 21 patients, detailing various TNM stages and surgical approaches used.
  • Results show a follow-up period averaging 96 months, with a 3-year survival rate of 61.9% and a 5-year rate of 52.4%, highlighting some postoperative complications.
  • The findings suggest that preservation of laryngeal function is possible in select cases, leading to satisfactory survival rates and improved quality of life for patients.
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Objective: To explore the feasibility and the related surgical techniques of laryngeal function preservation in surgical treatment of pyriform sinus cancer.

Methods: Two hundred and thirty cases (stage I, 6; stage II, 10; stage III, 91; stage IV, 123) with pyriform sinus cancer were treated surgically from 1978 to 1996 in the Department of Otorhinolaryngology of Qilu Hospital of Shandong University. The methods of removing tumor and repairing surgical defects were depended on the extension of lesions.

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Background & Objective: Chylous fistula, a severe complication after operation on neck, has close correlation with definite anatomical position and variation. Its treatment remains controversial. This study was to evaluate the validity of high negative pressure drainage for chylous fistula after neck dissection.

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Article Synopsis
  • The study aimed to analyze the expressions of bcl-2 and bax proteins throughout the cell cycle in laryngeal carcinoma and their relation to the cancer's development and prognosis.
  • The methods used included immunohistochemical staining, TUNEL techniques, and flow cytometry on samples from 15 vocal cord polyps and 387 laryngeal carcinomas.
  • Results showed that laryngeal carcinomas had higher bcl-2 expression and lower bax expression compared to vocal cord polyps, leading to reduced apoptosis, particularly in the G0G1 phase, and suggested that these factors may influence cancer progression and patient outcomes.
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Objective: To study the feasibility and effect of substituting esophagus with stomach or colon without thoracotomy in the treatment of cervical esophageal carcinoma with laryngeal function preserved.

Methods: Twenty-four patients with cervical esophageal carcinoma were retrospectively reviewed. The esophagus was resected and substituted with 19 gastric pull-up and 5 colon interposition.

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Article Synopsis
  • The surgical treatment of laryngeal cancer often requires managing the tongue-base, which is crucial for regaining laryngeal function, but previous methods were inadequate for effective repair.
  • A new approach involves using a sternohyoid myofascial flap for reconstruction after cancer removal, with promising results in partial laryngectomy cases.
  • Out of 32 patients, 81.3% were decannulated, most regained speaking abilities, maintained normal diets without complications, and showed good long-term survival rates.
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Article Synopsis
  • The study reviewed the surgical treatment of six patients with primary cervical tracheal cancer between 1997 and 1999.
  • Various surgical techniques were used to reconstruct the trachea, including flaps from nearby muscles and tissues.
  • Post-surgery, most patients had successful decannulation and maintained stable airways and good voice quality, with one case eventually dying from lung metastasis.
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Objective: To study the surgical treatment of tonsillar cancer.

Methods: Twenty-four patients with tonsillar cancer were treated with surgery and postoperative radiotherapy. The choice of surgical procedure was decided on the condition of the lesion.

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Objective: To study the methods and outcome of surgical management for pharyngo-esophageal stenosis.

Methods: Twenty-seven patients with pharyngo-esophageal stenosis from January 1983 to June 2001 were reviewed. Among 27 cases, there were 12 cases accompanied with laryngeal stenosis and one case accompanied with tracheal stenosis.

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