Publications by authors named "Xin Yi Xie"
Objective: This study aims to investigate the clinical application value of the central venous-arterial carbon dioxide partial pressure difference (Pv-aCO2) in postoperative cognitive dysfunction(POCD) in patients with acute aortic dissection.
Methods: A retrospective analysis was conducted on the general data of 236 patients. Blood gas samples were collected from the arterial and venous lines at various time points during the surgery, including before and after the initiation of cardiopulmonary bypass (CPB), immediately after CPB initiation, before and after deep hypothermic circulatory arrest, 30 min after rewarming, and 5 min before weaning from CPB.
Background: Patients with coronavirus disease 2019(COVID-2019) infections may still experience long-term effects, with fatigue being one of the most frequent ones. Clinical research on the long COVID in the Chinese population after infection is comparatively lacking.
Objective: To collect and analyze the long-term effects of non-severe COVID-19 infection patients and to develop a model for the prediction of fatigue symptoms.
Endophytic fungi from medicinal plants with specific pharmacological functions attract much attention to provide the possibility of discovering valuable natural drugs with novel structures and biological activities. is a rare and endangered karst endemic plant that is used as medicine and food homology in Guangxi, China. These plants have been reported to have antimicrobial, antitumor, antiviral, and anti-inflammatory activities.
View Article and Find Full Text PDFBackground: Language deficits frequently occur during the prodromal stages of Alzheimer's disease (AD). However, the characteristics of linguistic impairment and its underlying mechanism(s) remain to be explored for the early diagnosis of AD.
Methods: The percentage of silence duration (PSD) of 324 subjects was analyzed, including patients with AD, amnestic mild cognitive impairment (aMCI), and normal controls (NC) recruited from the China multi-center cohort, and the diagnostic efficiency was replicated from the Pitt center cohort.
Aim: To explore the functions of Chordin-like 2, which is encoded by , in the process of retinal pigmented epithelium (RPE) differentiation and damage repair.
Methods: The fetal RPE cells (fRPE) was obtained from aborted fetus which obeyed medical ethics. Real-time quantitative polymerase chain reaction was used to measure expression quantity of and other functional genes expression.
Article Synopsis
- * Adult-onset NCL (ANCL) is linked to specific gene mutations, including L115R, L116Δ, and C124_C133dup.
- * A new study identified a novel C128Y mutation in a young Chinese female with ANCL, causing abnormal palmitoylation and leading to the formation of lipofuscin deposits.
Article Synopsis
- - The study surveyed 434 Chinese clinicians using a 21-item questionnaire to gather their opinions on diagnosing and managing functional movement disorders (FMD), revealing that over 80% view atypical movement, multiple somatizations, and emotional issues as crucial for diagnosis.
- - A significant portion of respondents (75%) indicated that standard neurological tests should be done to exclude organic causes, with many also believing factors like previous organic diagnosis and evidence of physical injury strongly influence non-FMD diagnoses.
- - Results showed a broad inclination among clinicians to refer patients to neuropsychiatrists (77.4%) and psychologists experienced with FMD, but highlighted gaps in guidelines and training, prompting calls for more research and clearer practice protocols in China
Different cellular and molecular changes underlie the pathogenesis of Alzheimer's disease (AD). Among these, neuron-specific dysregulation is a necessary event for accumulation of classic pathologies including amyloid plaques. Here, we show that AD-associated pathophysiology including neuronal cell death, inflammatory signaling, and endolysosomal dysfunction is spatially colocalized to amyloid plaques in regions with abnormal microRNA-425 (miR-425) levels and this change leads to focal brain microenvironment heterogeneity, that is, an amyloid plaque-associated microenvironment (APAM).
View Article and Find Full Text PDFArticle Synopsis
- * The analysis of 8,097 AD patients revealed that those with AD had a reduced risk for several cancers, with an overall hazard ratio of 0.822 for developing cancers.
- * While lung cancer and prostate/testicular cancers showed a lower risk in AD patients, an increased risk of lymphoma was noted, indicating a complex relationship between AD and cancer.
Article Synopsis
- The heritability of familial late-onset Alzheimer's disease (FLOAD) is largely uncertain, with limited genetic profiles available; a study examined 90 FLOAD cases compared to 101 normal controls within the Chinese Han population.
- Targeted sequencing revealed lower mutation rates in the APP and PSEN genes, while the ε4 genetic risk factor was found to be more prevalent in FLOAD cases.
- Notably, novel pathogenic mutations, particularly frame-shift and nonsense mutations, were linked to FLOAD, impacting ACE protein levels without altering APP processing, supported by data from the Alzheimer's disease Neuroimaging Initiative (ADNI) database.
Article Synopsis
- The study investigated cardiovascular dysautonomia in Parkinson's disease patients who have no prior abnormal blood pressure history, focusing on 24-hour ambulatory BP monitoring.
- Among the 101 participants, 25.74% experienced orthostatic hypotension, significantly linked with higher nighttime systolic blood pressure and more severe nonmotor symptoms, autonomic issues, and cognitive decline.
- Additionally, over half of the patients displayed a reverse dipping pattern in blood pressure, which proved useful for identifying those at risk for orthostatic hypotension.
Background: Language dysfunction is a frequently reported symptom in Alzheimer's disease (AD). However, computer-assisted analysis of spontaneous speech in AD and mild cognitive impairment (MCI) is rarely used to date.
Objective: To characterize the language impairment in AD and amnestic MCI (aMCI) with computer-based automatic analysis via the "Automatic Speech Recognition (ASR) software for cognitive impairment V1.
Background: Identifying risk factors and mortality of individuals with Alzheimer's disease (AD) could have important implications for the clinical management of AD.
Objective: This pilot study aimed to examine the overall mortality of AD patients over a 10-year surveillance period in Shanghai, China. This study is an extension of our previous investigation on mortality of neurodegenerative diseases.