Swine farm wastewater is a major reservoir of antimicrobial resistance genes (ARGs). Anaerobic digestion (AD), widely implemented in farms, has been extensively studied for ARG removal. However, a comparative study on ARG removal efficiency across the four principal AD systems - up-flow anaerobic sludge blanket (UASB), continuous stirred tank reactor (CSTR), buried biogas digester (BBD), and septic tank (SPT) - is lacking.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
December 2024
Purpose: To establish an artificial intelligence (AI)-empowered multistep integrated (MSI) radiation therapy (RT) workflow for patients with nasopharyngeal carcinoma (NPC) and evaluate its feasibility and clinical performance.
Methods And Materials: Patients with NPC scheduled for MSI RT workflow were prospectively enrolled. This workflow integrates RT procedures from computed tomography (CT) scan to beam delivery, all performed with the patient on the treatment couch.
Math Biosci Eng
October 2024
Super-resolution (SR) of magnetic resonance imaging (MRI) is gaining increasing attention for being able to provide detailed anatomical information. However, current SR methods often use the complex convolutional network for feature extraction, which is difficult to train and not suitable for limited computation resources in the medical scenario. To tackle these bottlenecks, we propose a multi-distillation residual network (MDRN) for more differential feature refinement, which has a superior trade-off between reconstruction accuracy and computation cost.
View Article and Find Full Text PDFDysphagia is a common functional disorder that limits the variety of available foods. This study explored the coordination assembly of tannic acid (TA) with Fe to form a metal-phenolic network (MPN) and developed ovalbumin (OVA)/MPN via a pH-driven method as a novel emulsifier to stabilize high internal phase Pickering emulsions (HIPPEs). Results indicated that, following pH-driven treatment, the OVA/MPN composite particles exhibited smaller sizes, enhanced electrostatic repulsion, and improved stability.
View Article and Find Full Text PDFClin Transl Gastroenterol
December 2024
Background And Aims: Few studies have investigated the association between Life's Essential 8 (LE8) and abnormal bowel health. We aimed to investigate the relationship between LE8 and diarrhea and constipation in the adult population of the United States.
Methods: This cross-sectional study, based on population data, utilized information from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2010.
Objective: This study aimed to systematically review the efficacy of telehealth approaches in alleviating depressive and anxiety symptoms in patients with chronic obstructive pulmonary disease (COPD) using evidence from randomized controlled trials (RCTs).
Methods: This systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) checklist. Databases including PubMed, Embase, Web of Science, and the Cochrane Library were searched for RCTs from database inception to June 2024.
Healthcare (Basel)
December 2024
: Functional bowel disorders (FBDs) have detrimental effects on young adults, but the risk factors were not fully explored. This study aimed to investigate the prevalence and potential risk factors of FBDs in college freshmen, including, in particular, the association between passive smoking and the risk and symptoms of FBDs. : A cross-sectional study was conducted in September 2019 in freshmen of Huazhong University of Science and Technology with a random cluster sampling method.
View Article and Find Full Text PDFBackground: The objective of this study was to investigate the effect of mammalian-enabled protein (Mena) on invasion and metastasis of HPV16-related oral squamous cell carcinoma (OSCC) and the underlying mechanism.
Materials And Methods: The Mena gene expression profile of HPV-related OSCC was analyzed from the TCGA, GEO and TIMER databases. Immunohistochemistry was performed to study Mena, and the expression of invasion and metastasis-related markers and their clinicopathological characteristics.
Piglet diarrhea poses significant economic losses to the pig industry, posing a worldwide challenge that urgently needs to be addressed in pig breeding practices. Porcine rotavirus (PoRV) is an important viral diarrhea pathogen in piglets, with a high incidence rate and a tendency to cause growth retardation. To enhance the sensitivity and specificity of PoRV detection, we sequenced the NSP3 gene of G5 and G9 genotypes of rotavirus A (RVA), enabling simultaneous detection of the two serotypes.
View Article and Find Full Text PDFIn recent years, the industrial substitution of long-chain per- and polyfluoroalkyl substances (PFAS) with short-chain alternatives has become increasingly prevalent, resulting in the widespread environmental detection of perfluorohexanesulfonic acid (PFHxS), a short-chain PFAS. However, there remains limited information about the potential adverse effects of PFHxS at environmental concentrations to wildlife. Here, early life stage zebrafish () were exposed to environmentally relevant concentrations of PFHxS to better characterize the adverse effects of PFHxS on aquatic organisms.
View Article and Find Full Text PDFIschemic stroke (IS) is a highly lethal type of cardiovascular and cerebrovascular disease. Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut-brain axis as a therapeutic target. In this study, we evaluated the regulatory effect of (L.
View Article and Find Full Text PDFBackground: Cerebral ischemia-reperfusion injury (CIRI) is a key pathophysiological process that leads to stroke mortality, with TLR4-mediated inflammation playing a crucial role. Our previous research highlighted the neuroprotective effects of the phytoestrogen calycosin on CIRI, although the precise mechanism remains unclear. This study aimed to explore the effects of calycosin on the HMGB1/TLR4/NF-κB signaling pathway in rat models of CIRI, both in vivo and in vitro.
View Article and Find Full Text PDFThe rising incidence of drug-induced liver injury (DILI) parallels contemporary dietary shifts that have transformed the composition of human gut microbiota. The relationship between these phenomena remains unknown. Here, it is unveiled that a high fiber diet (HFiD) provides substantial protection against DILI, whereas a western style diet (WSD) significantly exacerbates DILI.
View Article and Find Full Text PDFBackground: The BOADICEA model predicts breast cancer risk using cancer family history, epidemiological and genetic data. We evaluated its validity in a large prospective cohort.
Methods: We assessed model calibration, discrimination and risk classification ability in 217,885 women (6,838 incident breast cancers) aged 40-70 years old of self-reported White ethnicity with no previous cancer from the UK Biobank.
Skeletal muscles represent a role model in soft robotics featuring agile locomotion and incredible mechanical robustness. However, existing actuators lack an optimal combination of actuation parameters (including actuation modes, work capacity, mechanical strength, and damage repair) to rival biological tissues. Here, a biomimetic structural design strategy via multilevel relaxations (α/β/γ/δ-relaxation) modulation is proposed for mechanical robust and healable actuator materials with muscle-like diastole and contraction abilities by orientational alignment of dendritic polyphenol-modified nano-assembles in eutectogels.
View Article and Find Full Text PDFInteractive segmentation allows active user participation to enhance output quality and resolve ambiguities. This may be especially indispensable to medical image segmentation to address complex anatomy and customization to varying user requirements. Existing approaches often encounter issues such as information dilution, limited adaptability to diverse user interactions, and insufficient response.
View Article and Find Full Text PDFBackground: Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phlebovirus that causes viral hemorrhagic fever. Pandemic concerns have arisen due to the increased human-to-human transmission and high mortality rate, highlighting the urgent need for specific therapeutics.
Methods: Our observational study characterized the memory B cell response to natural SFTSV infection in four survivors.
Lignin- and tannin-like phenolic compounds are shown to be the major compositions of electron donating moieties (EDM) of aquatic natural organic matter (NOM). However, little is known about the compositions of EDMs within effluent organic matter (EfOM). In the present study, chlorine dioxide (ClO) was used as a selectively oxidative probe to investigate the difference in the molecular composition of EDM between NOM and EfOM due to its high selectivity towards electron-rich compounds.
View Article and Find Full Text PDFComput Methods Programs Biomed
November 2024
Background And Objectives: Acoustofluidic manipulation of particles and biological cells has been widely applied in various biomedical and engineering applications, including effective separation of cancer cell, point-of-care diagnosis, and cell patterning for tissue engineering. It is often implemented within a polydimethylsiloxane (PDMS) microchannel, where standing surface acoustic waves (SSAW) are generated by sending two counter-propagating ultrasonic waves on a piezoelectric substrate.
Methods: In this paper, we develop a full cross-sectional model of the acoustofluidic device using finite element method, simulating the wave excitation on the substrate and wave propagation in both the fluid and the microchannel wall.
Wireless and battery-free radio-frequency (RF) sensors can be used to create physical spaces that ambiently sense and respond to human activities. Making such sensors ultra-flexible and transparent is important to preserve the aesthetics of living environments, accommodate daily activities, and functionally integrate with objects. However, existing RF sensors are unable to simultaneously achieve high transparency, flexibility, and the electrical conductivity required for remote room-scale operation.
View Article and Find Full Text PDFPlant Phenomics
December 2024
The rice panicle traits substantially influence grain yield, making them a primary target for rice phenotyping studies. However, most existing techniques are limited to controlled indoor environments and have difficulty in capturing the rice panicle traits under natural growth conditions. Here, we developed PanicleNeRF, a novel method that enables high-precision and low-cost reconstruction of rice panicle three-dimensional (3D) models in the field based on the video acquired by the smartphone.
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