Automated assessment of endometrial receptivity for screening recurrent pregnancy loss risk using deep learning-enhanced ultrasound and clinical data.

Background: Recurrent pregnancy loss (RPL) poses significant challenges in clinical management due to an unclear etiology in over half the cases. Traditional screening methods, including ultrasonographic evaluation of endometrial receptivity (ER), have been debated for their efficacy in identifying high-risk individuals. Despite the potential of artificial intelligence, notably deep learning (DL), to enhance medical imaging analysis, its application in ER assessment for RPL risk stratification remains underexplored.

Assembly and comparative analysis of the complete mitogenome of var. , an exceptional berry plant possessing sweet leaves.

var. is a special berry plant of in the Rosaceae family. Its leaves contain high-sweetness, low-calorie, and non-toxic sweet ingredients, known as rubusoside.

The NAC transcription factor LpNAC48 promotes trichome formation in Lilium pumilum.

Trichomes play a crucial role in plant resistance to abiotic and biotic stresses, and their development and characteristics vary across different species. This study demonstrates that trichomes of Lilium pumilum exhibit synchronized growth during flower bud differentiation and enhance the plant's adaptability to UV-B radiation and aphid infection. We identified LpNAC48, a NAC family transcription factor (TF), that interacted with the B-box (BBX) family TF LpBBX28, during trichome formation in L.

Evaluation of the ability of large language models to self-diagnose oral diseases.

Large language models (LLMs) offer potential in primary dental care. We conducted an evaluation of LLMs' diagnostic capabilities across various oral diseases and contexts. All LLMs showed diagnostic capabilities for temporomandibular joint disorders, periodontal disease, dental caries, and malocclusion.

Hotspots of genetic change in Yersinia pestis.

The relative contributions of mutation rate variation, selection, and recombination in shaping genomic variation in bacterial populations remain poorly understood. Here we analyze 3318 Yersinia pestis genomes, spanning nearly a century and including 2336 newly sequenced strains, to shed light on the patterns of genetic diversity and variation distribution at the population level. We identify 45 genomic regions ("hot regions", HRs) that, although comprising a minor fraction of the genome, are hotbeds of genetic variation.

[The association between unhealthy lifestyle and depressive symptoms, anxiety symptoms, and stress among secondary school students in Jiangsu Province, China].

To analyze the association between unhealthy lifestyles and depressive symptoms, anxiety symptoms and stress among secondary school students in Jiangsu Province. From September to November 2023, a multistage stratified cluster random sampling method was used to select secondary school students from 13 districts and cities in Jiangsu Province. A questionnaire survey was conducted on their unhealthy lifestyles (low physical activity, smoking, drinking, internet addiction, poor sleep quality, and unhealthy diet), as well as their depressive symptoms, anxiety symptoms and stress.

Ultra-low power-consumption OLEDs via phosphor-assisted thermally-activated-delayed-fluorescence-sensitized narrowband emission.

The further success of OLED beyond conventional low-luminance display applications has been hampered by the low power efficiency (PE) at high luminance. Here, we demonstrate the strategic implementation of an exceptionally high-PE, high-luminance OLED using a phosphor-assisted thermally-activated-delayed-fluorescence (TADF)-sensitized narrowband emission. On the basis of a TADF sensitizing-host possessing a fast reverse intersystem crossing, an anti-aggregation-caused-quenching character and a good bipolar charge-transporting ability, this design achieves not only a 100% exciton radiative consumption with decay times mainly in the sub-microsecond regime to mitigate exciton annihilations for nearly roll-off-free external quantum efficiency, but also narrowband emission with both small energetic loss during energy transfer and resistive loss with increasing luminance.

Identification of JNK-JUN-NCOA axis as a therapeutic target for macrophage ferroptosis in chronic apical periodontitis.

This study aimed to investigate the involvement of macrophage ferroptosis in chronic apical periodontitis (CAP) and determine if blocking JNK/JUN/NCOA4 axis could alleviate CAP by regulating macrophage ferroptosis. Firstly, the models of apical periodontitis (AP) and models of CAP, including clinical specimens and rats' periapical lesions, were utilized to investigate the role of macrophage ferroptosis in CAP by detecting the ferroptosis related factors. The activation of the JNK/JUN/NCOA4 axis was observed in CAP models.

Polysaccharides derived from golden mushroom ( Fr.) modulate gut microbiota and enhance intestinal barrier function to ameliorate dextran sulfate sodium-induced colitis in mice.

Introduction: Inflammatory bowel disease (IBD), including ulcerative colitis, is marked by intestinal barrier disruptions, immune system dysregulation, and an imbalance in the gut microbiota. The golden chanterelle mushroom, Fr., a popular edible mushroom, has shown potential therapeutic benefits.

Mettl14 and Mettl3 Work Cooperatively to Regulate Retinal Development.

N-methylenadenosine (mA) modification, the most abundant epitranscriptomic modification in eukaryotic mRNAs, has been shown to play crucial roles in regulating various aspects of mRNA metabolism and functions. In this study, we applied the Cre-Loxp conditional knockout system to investigate the role of the core components of the mA methyltransferase complex, METTL14 and METTL3, in retinal development. Our results showed that the double absence of Mettl14 and Mettl3 caused structural disturbance in the retina and prolonged the proliferation activity of retinal progenitor cells.

Thermal aggregation and gelation behaviors of glucono-δ-lactone-induced soy protein hydrolysate gels: Effects of protein and coagulant concentrations.

In this study, a novel acid-induced heat-set soy protein hydrolysate (SPH) gel was successfully developed. The effects of protein (7 and 8 wt%) and glucono-δ-lactone (GDL, 4, 6, 8, and 10 wt%) concentrations on its aggregation and gelation behaviors were investigated by evaluating the structural, rheological, textural, and physical properties of the SPH gel. The structural properties revealed that GDL promoted the formation of SPH aggregates and gels, primarily via disulfide bonds and hydrophobic interactions, which were closely related to the unfolding of the protein structure, exposed hydrophobic groups, decreased protein solubility, and increased particle size and turbidity during the heating process.

FXYD1 was identified as a hub gene in recurrent miscarriage and involved in decidualization via regulating Na/K-ATPase activity.

Purpose: Recurrent miscarriage (RM) is a distressing and complicated adverse pregnancy outcome. It is commonly recognized that insufficient decidualization could result in RM, but the molecular mechanisms of decidual impairment are still not fully understood. Thus, this study aimed to identify novel key genes potentially involved in RM and explore their roles played in endometrial decidualization.

Self-efficacy and healthy lifestyle behaviors as mediators between COVID-19 care knowledge and health status.

The COVID-19 epidemic has affected the psychological well-being and daily life of college students, leading to a decrease in their quality of life. Health status can be influenced by a variety of factors. This study aims to assess the current health status of university students and explore the relationships among COVID-19 care knowledge, self-efficacy, healthy lifestyle behaviors, and health status and how these factors are influenced.

Lactoferrin-modified nanoemulsions enhance brain-targeting and therapeutic efficacy of arctigenin against Toxoplasma gondii-induced neuronal injury.

Toxoplasma gondii, a neurotropic protozoan parasite, affects the central nervous system and causes various neurological disorders. Previous studies have demonstrated that Arctigenin (AG) exhibits anti-T. gondii activity and reduces depression-like behaviors induced by T.

Enhanced Eicosapentaenoic Acid Production via Synthetic Biological Strategy in .

The rational dietary ratio of docosahexaenoic acid (DHA) to eicosapentaenoic acid (EPA) can exert neurotrophic and cardiotrophic effects on the human body. The marine microalga produces EPA yet no DHA, and thus, it is considered an ideal EPA-only model to pursue a rational DHA/EPA ratio. In this study, synthetic biological strategy was applied to improve EPA production in .

[Effects of exogenous abscisic acid on grain filling characteristics, starch accumulation, and endogenous hormones in maize under early post-anthesis high temperature stress].

We investigated the effects of exogenous abscisic acid (ABA) on grain filling, starch accumulation, and endogenous hormones in maize (both the heat-tolerant maize variety Zhengdan 958 (ZD958) and the heat-sensitive variety Xianyu 335 (XY335)) under early post-anthesis high temperature stress by simulating high temperature stress for a period of 6 to 12 days post-anthesis in 2022 and 2023. There were three treatments: spraying water at ambient temperature as the control, spraying water at high temperature, and spraying ABA at high temperature. The results showed that early post-anthesis high temperature stress resulted in a significant reduction in grain weight and yield in maize, with XY335 showing a greater reduction than ZD958.

Region-specific biomechanical characterization of ascending thoracic aortic aneurysm of hypertensive patients with bicuspid aortic valves.

Hypertension and bicuspid aortic valve (BAV) are key clinical factors that may affect local biomechanical properties of ascending thoracic aortic aneurysms (ATAAs). This study sought to investigate regional differences in biaxial mechanical properties of the ATAAs for the hypertensive patients with BAV. Fresh ATAA samples were harvested from 16 hypertensive patients (age, 66 ± 9 years) undergoing elective aortic surgery.

Sea conch () peptide hydrolysate regulates NF-κB pathway and restores intestinal immune homeostasis in DSS-induced colitis mice.

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract. Sea conch peptide hydrolysate (CPH) was produced by enzymatic digestion of fresh conch meat with trypsin enzyme. To analyze the molecular composition, functional groups, and structural morphology of the hydrolysate, we employed liquid chromatography-mass spectrometry (LC-MS), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM).

Associations between Metals, Serum Folate, and Cognitive Function in the Elderly: Mixture and Mediation Analyses.

Exposure to metals may potentially impact cognitive health in the elderly; however, the evidence remains ambiguous. The specific role of serum folate in this relationship is also unclear. We aimed to evaluate the individual and joint impact of metals on cognition in the elderly from the United States and explore the potential mediating effect of serum folate.

Reduction of Hepatic Fat Content by Dulaglutide for the Treatment of Diabetes Mellitus: A Two-Centre Open, Single-Arm Trial.

Background: With the elevated level of NAFLD prevalence, the incidence of diabetes, hypertension, metabolic syndrome and other diseases is also significantly elevated. GLP-1RA can exert weight loss, glucose-lowering effects and various nonglycaemic effects. However, the relationship between quantitative reduction in hepatic fat content and improvement of pancreatic islet function by GLP-1RA is unclear.

Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis.

Endometriosis and adenomyosis are debilitating gynecological conditions that severely affect the quality of life of women. Traditional diagnostic and treatment methods, including laparoscopic surgery and hormonal therapy, face significant limitations such as incomplete lesion detection, high recurrence rates, and adverse side effects. Emerging bioengineering technologies offer promising solutions for precise diagnosis and therapy of these diseases.

PAGE-based transfer learning from single-cell to bulk sequencing enhances model generalization for sepsis diagnosis.

Sepsis, caused by infections, sparks a dangerous bodily response. The transcriptional expression patterns of host responses aid in the diagnosis of sepsis, but the challenge lies in their limited generalization capabilities. To facilitate sepsis diagnosis, we present an updated version of single-cell Pair-wise Analysis of Gene Expression (scPAGE) using transfer learning method, scPAGE2, dedicated to data fusion between single-cell and bulk transcriptome.

Parental health belief model constructs associated with oral health behaviors, dental caries, and quality of life among preschool children in China: a cross-sectional study.

Background: Early childhood caries (ECC) is a prevalent health problem that negatively affects both overall health and oral health-related quality of life (OHRQoL). This study investigated the association between health belief model (HBM) constructs and oral health behaviors, dental caries, and OHRQoL in preschool children in China.

Methods: A total of 1562 preschool children aged 3 to 6 years were recruited from six public kindergartens in Hangzhou, Zhejiang Province, by using stratified cluster sampling.