TTC7A-ALK, a novel ALK fusion variant identified in a patient with metastatic lung adenocarcinoma, exhibits excellent response to crizotinib.

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. ALK gene rearrangement has been identified in 3 % to 5 % of the patients with NSCLC. Thanks to the advancements in second-generation sequencing technology, an increasing number of novel fusion partners have been identified.

Challenge-Hindrance Stressors and Employability: The Combined Role of the Energy-Motivation Process and Organizational Investment.

Purpose: This study investigates how challenge-hindrance stressors influence employability through the energy-motivation mechanism and explores the moderating role of pay satisfaction and perceived career opportunity based on the JD-R model.

Methods: Three-wave time-lagged longitudinal data of 206 employees are analyzed using latent structural equation modelling.

Results: First, challenge stressors have an indirect positive effect on employability, mainly through intrinsic motivation, while hindrance stressors have an indirect negative effect on employability, mainly through emotional exhaustion.

Will Job Crafters Stay or Leave? The Roles of Organizational Instrumentality and Inclusive Leadership.

Although studies have indicated the influences of job crafting on contemporary employees' working outcomes, the path from job crafting to turnover intention is still unexplored in depth. Drawing on goal facilitation theory, we delineate how job crafting relates to turnover intention through organizational instrumentality and is conditioned by inclusive leadership. We collected data from 218 employees from Chinese high-tech companies at two different time points by submitting survey questionnaires.

Regulatory Focus, Boundaryless Mindset, and Creativity Among Chinese College Students: A Trait Activation Perspective.

We explored the impact of two types of regulatory focus on creativity among 330 college students in China, along with the mediating role of boundaryless mindset and moderating role of stressful life events. A three-wave survey showed that both promotion focus and prevention focus positively predicted the creativity in college students, but the positive effect of promotion focus on the creativity in college students was greater than that of prevention focus; boundaryless mindset mediated the relationship between regulatory focus and creativity; stressful life events moderated the direct effect that promotion focus has on boundaryless mindset, and it also moderated the indirect effect that promotion focus has on creativity boundaryless mindset. These results extend the existing research on creativity and establish a new mediating mechanism and boundary conditions between regulatory focus and creativity in college students.

How Can Job Crafting Be Reproduced? Examining the Trickle-Down Effect of Job Crafting from Leaders to Employees.

This study seeks to examine how and when job crafting trickles down from leaders to followers in a team context. Drawing on social learning theory, we hypothesize that team leaders' job resources mediate the relationship between team leaders' job crafting and team members' job crafting. Empowering leadership is proposed to strengthen the mediation effect, such that under a stronger (higher) empowering leadership style the relationship between team leaders' job resources and team members' job crafting is further strengthened, thereby positively influencing the overall mediated relationship.

Combine Your "Will" and "Able": Career Adaptability's Influence on Performance.

Adaptivity and adaptability are two key elements representing one's "willingness" and "ability," respectively, in the career construction theory (CCT) framework. On the basis of CCT and complemented by the visual of resources in the conservation of resources theory, this study combines career issues and performance and examines the joint effect of adaptivity and adaptability on career self-management which will lead to improved performance. Using a sample of Chinese employees ( = 232), the study first examines the mediating role that career self-management plays between career adaptability and performance and then tests the moderating role of proactive personality.

Proteome analysis identifies the role of heat stress in production of progeny HCV in Huh7 cells harboring intact HCV.

Objective: The intact hepatitis C virus (HCV) cell culture system has provided a powerful tool for studying the interaction between HCV and host cell. We applied proteomic techniques to globally analyze the protein expression profiles of Huh7 in the absence and presence of HCV, with the aim to elucidate the host cell components response to HCV.

Methods: Proteomic and molecular biology techniques were used for this aim.