Publications by authors named "Xin Xiong"

Bruton's tyrosine kinase inhibitors (BTKis) exhibit significant interindividual pharmacokinetics, making therapeutic drug monitoring (TDM) a promising approach for personalized therapy. However, simultaneous quantification of multiple BTKis poses technical challenges. A unified protocol for BTKis detection would be clinically desirable.

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This retrospective study aimed to comprehensively investigate the impact of non-surgical treatments on condylar osseous changes in adult patients with degenerative joint disease (DJD). Radiographic and clinical data were collected for analysis. Cone-beam computed tomography (CBCT) was used to diagnose DJD, including flattening, erosion, osteophytes, sclerosis and cysts.

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The emission factors and characteristics of pollutants from river vessels are critical for understanding the environmental impact of ship emissions, particularly in inland waterways. However, research gaps remain regarding emissions of volatile organic compounds (VOCs) and intermediate-volatility organic compounds (IVOCs) from river vessels. In this study, we collected and analyzed organic vapor emissions, including non-methane hydrocarbon (NMHCs), oxygenated volatile organic compounds (OVOCs) and IVOCs, from three river vessels under different operating conditions.

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This study aimed to investigate sex differences in craniomaxillofacial parameters in children and adolescents. Lateral cephalograms were obtained from 340 subjects (141 male, 199 female) aged 6 to 18 years, and their craniofacial characteristics and cervical vertebral maturity were assessed using the quantitative cervical vertebral maturity (QCVM) method. Age-based stratified analyses on craniofacial parameters and further comparison in QCVM Ⅲ subjects were performed.

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Peak particle velocity (PPV) serves as a critical metric in assessing the appropriateness of blasting design parameters. However, existing methods for accurately measuring PPV remain insufficient. To develop a robust PPV prediction model, this study integrates the Extreme Gradient Boosting (XGBoost) algorithm with four distinct optimization techniques: Runge Kutta Optimizer (RUN), Equilibrium Optimizer (EO), Gradient-Based Optimizer (GBO), and Reptile Search Algorithm (RSA).

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Electronic Health Record (EHR) systems are particularly valuable in pediatrics due to high barriers in clinical studies, but pediatric EHR data often suffer from low content density. Existing EHR code embeddings tailored for the general patient population fail to address the unique needs of pediatric patients. To bridge this gap, we introduce a transfer learning approach, MUltisource Graph Synthesis (MUGS), aimed at accurate knowledge extraction and relation detection in pediatric contexts.

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Objective: This study aimed to thoroughly explore the relationship between individual oral behavior and the differing numbers of temporomandibular disorder (TMD) symptom in the general population.

Methods: A total of 565 participants were recruited and completed a questionnaire containing demographic characteristics, eight specific oral behaviors, and five major TMD symptoms (5Ts) checklist. Multivariate linear regression analysis was performed to assess the relationship between individual oral behavior and the number of TMD symptoms, after controlling for confounders.

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Objectives: Oral behaviours (OB) are some oral overuse behaviours which could be observed in patients with temporomandibular disorders (TMD). This study aims to investigate the association between TMD-related quality of life and OB to enhance understanding of these behaviours.

Methods: A total of 319 participants diagnosed with TMD were included in this research.

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Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer, the most common type of breast cancer, is facing challenges such as endocrine therapy resistance and distant relapse. Immunotherapy has shown progress in treating triple-negative breast cancer, but immunological research on HR+/HER2- breast cancer is still in its early stages. Here, we performed a multi-omics analysis of a large cohort of HR+/HER2- breast cancer patients (n = 351) and revealed that HR+/HER2- breast cancer possessed a highly heterogeneous tumor immune microenvironment.

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Cellular deconvolution via bulk RNA sequencing (RNA-seq) presents a cost-effective and efficient alternative to experimental methods such as flow cytometry and single-cell RNA-seq (scRNA-seq) for analyzing the complex cellular composition of tumor microenvironments. Despite challenges due to heterogeneity within and among tumors, our innovative deep learning-based approach, DeSide, shows exceptional accuracy in estimating the proportions of 16 distinct cell types and subtypes within solid tumors. DeSide integrates biological pathways and assesses noncancerous cell types first, effectively sidestepping the issue of highly variable gene expression profiles (GEPs) associated with cancer cells.

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4-Hydroxy-2-nonenal (HNE), a reactive compound produced during the peroxidation of polyunsaturated fatty acids, is implicated in numerous diseases and the degradation of food quality. Although the detection of HNE in meat has a long history, methods for detecting HNE in freshwater fish are inadequate due to the significant influence of matrix differences (i.e.

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Graph contrastive learning (GCL) shows excellent potential in unsupervised graph representation learning. Data augmentation (DA), responsible for generating diverse views, plays a vital role in GCL, and its optimal choice heavily depends on the downstream task. However, it is impossible to measure task-relevant information under an unsupervised setting.

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Objective: Growing researches explore vitamin D's role in temporomandibular disorders (TMDs), but the link between vitamin D and TMDs remains debated. To clarify the causal relationship, we conducted a Mendelian randomization (MR) analysis using data from genome-wide association studies (GWAS).

Subjects And Methods: The GWAS dataset of vitamin D (GWAS ID: ukb-d-30890_irnt; sample size: 329247) was obtained from the IEU Open GWAS project.

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This study describes two different doses of dexmedetomidine combined with tiletamine-zolazepam (TZ) for anesthesia in snow leopards (Panthera uncia). A total of 11 adult snow leopards were anesthetized in Xining City, Qinghai Province, China from November 2019 to June 2023. We recorded the onset time, anesthesia duration, head-up time, and walking time.

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Aims And Objectives: This study aimed to develop and validate a knowledge, attitude, and practice scale of antibiotic use for Chinese medical students.

Method: A five-phased procedure was adopted: (a) A item pool was constructed after literature review; (b) Delphi method was used to refine the items; (c) A pilot study was conducted to clarify the item; (d) Item analysis and exploratory factor analysis were used to finalize the scale; (e) Content validity, construct validity and reliability of the scale were analysed.

Results: The scale of 32 items, respectively 15, 9, and 8 for knowledge, attitude, and practice, was finalized.

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Article Synopsis
  • Type 2 diabetes mellitus (T2DM) can lead to serious complications like heart failure (HF), yet there's limited research on how insulin treatment compares to other medications in terms of HF risk.
  • This study utilized real-world insurance claims data to assess the long-term HF risk of insulin therapy versus other glucose-lowering medications like GLP-1 RAs, DPP-4Is, and SGLT2Is among T2DM patients.
  • Results indicated that insulin users had significantly higher 5-year incident HF rates compared to patients using other therapies, especially in those already at high risk for heart failure.
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This study aims to investigate the impact of postgraduate education on the comprehension of Temporomandibular Disorders (TMDs) among dental professionals. A cross-sectional observational study was conducted, involving 348 dental professionals, including students and practicing dentists, categorized based on their educational background into two groups: bachelor's degree or lower (Group B) and master's degree or higher (Group M). Questionnaires were utilized to assess attitudes and knowledge across four TMDs-related domains.

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Article Synopsis
  • Parkinson's disease (PD) involves neurodegeneration linked to toxic accumulation of phosphorylated α-synuclein and mutations in the parkin gene, affecting early onset PD but lacking clear mechanisms.
  • Researchers developed parkin-deficient monkey models using CRISPR technology, revealing that the absence of parkin leads to neurodegeneration in the substantia nigra and that parkin's effectiveness decreases with age due to increased insolubility.
  • The study highlights that phosphorylated parkin plays a vital role in protecting against neurodegeneration and reducing toxic α-synuclein levels, indicating that targeting parkin phosphorylation could be a promising therapeutic strategy for PD.
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  • High-performance dielectric energy-storage ceramics improve electrostatic capacitors but face challenges in balancing polarizability and breakdown strength for optimal energy density.
  • A new dual-phase structure is created using (BiNa)TiO-BaTiO ceramics, which enhances performance through phase separation and a solid-state reaction method.
  • These ceramics achieve a record energy density of 23.6 J/cm³ with 92% efficiency while exhibiting high polarization, low hysteresis, and increased resistivity, promising better energy-storage capabilities in ferroelectrics.
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Background: Breast cancer (BC) is the most common cancer in women and poses a significant health burden, especially in China. Despite advances in diagnosis and treatment, patient variability and limited early detection contribute to poor outcomes. This study examines the role of CD8 + T cells in the tumor microenvironment to identify new biomarkers that improve prognosis and guide treatment strategies.

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Article Synopsis
  • - Significant advancements in tumor treatment using nano-enzymes have been made, but the short life and limited diffusion of reactive oxygen species (ROS) make it difficult to effectively target tumor cells.
  • - A new nanoplatform, called hollow Prussian blue/artesunate/methylene blue (HPB/ATS/MB), has been developed to improve the delivery and effectiveness of treatments by utilizing Prussian blue to release iron (II) in a way that enhances radical stability.
  • - The HPB/ATS/MB nanoparticles leverage multiple therapies, including photothermal, photodynamic, and radical therapy, demonstrating a combined effect in weakening tumor cells under specific conditions.
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Lead-free Mn-based metal halide materials are now being considered as clean candidates for backlight displays and lights due to the d-d transition, diverse components, and environmental friendliness. Therefore, efficient and stable Mn-based metal halide phosphors are in great demand for practical applications. In this work, adopting the mixed-ligand strategy, a series of [(CH)N][(CH)N]MnCl phosphors were synthesized by mechanochemical process.

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Background: Whether pain, jaw function and quality of life are correlated with disc positions is controversial, and similar studies evaluating disc positions by magnetic resonance imaging (MRI) are very limited.

Objective: This study evaluated the pain, mandibular function and quality of life of the temporomandibular disorders (TMDs) patients with different disc positions according to MRI, and the relationship among them.

Methods: Three hundred and thirty-five participants were included.

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Boron/nitrogen (B/N)-doped polycyclic aromatic hydrocarbons (PAHs) with the multiple resonance (MR) effect are promising for organic light-emitting diodes (OLEDs) because of their narrowband emission and thermally activated delayed fluorescence (TADF) characteristics. Nevertheless, exploring the variety of such emitters is challenging because of the tricky and limited synthetic protocols. Herein, we designed a novel B/N-doped PAH, L-DABNA-1, whose backbone (L-DABNA) could not be achieved via conventional routes (e.

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