DNA and Histone Methylation Regulates Different Types of Fruit Ripening by Transcriptome and Proteome Analyses.

Methylation affects different aspects of genetic material stability, gene expression regulation, and histone modification. The previous reports depicted that DNA and histone methylation regulates plant growth and development. In this study, we evaluated the effects of DNA and histone methylation on 'Hongjia' strawberry and 'Lichun' tomato.

Acid-Responsive Aggregated Gold Nanoparticles for Radiosensitization and Synergistic Chemoradiotherapy in the Treatment of Esophageal Cancer.

Radiotherapy and chemotherapy are limited by insufficient therapeutic efficacy of low-dose radiation and nonspecific drug biodistribution. Herein, an acid-responsive aggregated nanosystem (AuNPs-D-P-DA) loaded with doxorubicin (DOX) is designed for radiosensitization and synergistic chemoradiotherapy. In response to the acid microenvironment of esophageal cancer (EC), small-sized AuNPs-D-P-DA forms large-sized gold nanoparticle (AuNPs) aggregates in tumor tissues to hinder the backflow of AuNPs to the circulation, resulting in enhanced tumor accumulation and retention.

Lateral Malleolus Reconstruction After Tumor Resection in Children: A Case Report and Literature Review.

Background: Pediatric reconstruction of lateral malleolus was necessary and challengeable. Up to now, vascularized fibular was the optimal graft to reconstruct epiphyseal defection. However, the sophisticated microvascular operation has limited the wide application of this technique.

Prenatal Diagnosis of Two Common Inborn Errors of Metabolism by Genetic and Mass Spectrometric Analysis of Amniotic Fluid.

Methylmalonic acidaemia (MMA) and ornithine transcarbamylase deficiency (OTCD) are both intoxication-type inborn errors of metabolism (IEM). Presently, genetic testing is the primary method for prenatally diagnosing these diseases. However, some reports have demonstrated that mass spectrometry approaches can prenatally diagnose some forms of inborn errors of metabolism using amniotic fluid.

Clustering emission of cucurbit[n]urils in the solid- and solution-state induced by the outer surface interactions of cucurbit[n]urils.

Atypical luminescent compounds that do not contain conventional chromophores emit light due to clustering and have important basic research value and a broad range of potential applications. To date, most atypical luminescent compounds are small molecules or polymers containing groups such as cyano, carbonyl and hydroxyl. In this work, driven by some sporadic and accidental luminescence phenomena observed for cucurbit[n]urils (Q[n]s), the luminescent properties and mechanism of Q[n]s in the solid- and solution-state were systematically studied and the clustering emission of Q[n]s confirmed.

Selective Separation Catalysis Membrane for Highly Efficient Water and Soil Decontamination via a Persulfate-Based Advanced Oxidation Process.

The application of sulfate radical advanced oxidation for organic pollutant removal has been hindered by some shortages such as the recycling difficulty of a powered catalyst, the low utilization efficiency of oxidants, and the secondary pollution (including soil acidification) after reaction. Herein, we fabricate a selective separation catalysis membrane (SSCM) for a highly efficient and environment-friendly persulfate-based advanced oxidation process. The SSCM comprises a top polydimethylsiloxane layer which is selectively penetrable to hydrophobic organic pollutants, followed by a catalyst layer with a magnetic nitrogen-doped porous carbon material, targeting the advanced oxidation of the selected pollutants.

Hospitalization, interpersonal and personal factors of social anxiety among COVID-19 survivors at the six-month follow-up after hospital treatment: the minority stress model.

Background: As a highly infectious disease with human-to-human transmission characteristics, COVID-19 has caused panic in the general public. Those who have recovered from COVID-19 may experience discrimination and internalized stigma. They may be more likely to worry about social interaction and develop social anxiety.

The development and progress of nanomedicine for esophageal cancer diagnosis and treatment.

Esophageal cancer (EC) is a common gastrointestinal malignancy with poor prognosis and high mortality. Although combined therapeutic strategies have been developed, the 5-year survival rate of patients with EC remains relatively poor. Conventional anti-cancer drug delivery techniques have some shortcomings, such as nontargeted delivery and nonspecific toxicity.

Post-traumatic Stress Disorder Symptoms in COVID-19 Survivors 6 Months After Hospital Discharge: An Application of the Conservation of Resource Theory.

COVID-19 survivors who had acute respiratory symptoms might experience prolonged post-traumatic stress disorder (PTSD) due to further rehabilitation, somatic symptoms and related distress. The conservation of resource (COR) theory is a well-developed theory to understand how people develop PTSD symptoms in traumatic events. The current study aimed to examine the potential factors of PTSD symptoms and interrelationships among this factors among COVID-19 survivors based on the COR theory.

Enantioselective bioaccumulation and toxicity of rac-sulfoxaflor in zebrafish (Danio rerio).

Sulfoxaflor is a fourth-generation neonicotinoid insecticide mainly used to control sap-feeding pests. In this study, four stereoisomers of sulfoxaflor were separated using HPLC, and the absolute configurations of three stereoisomers were identified via single-crystal X-ray diffraction. First, the stability and isomerization of the four enantiomers and rac-sulfoxaflor in water and seven organic solvents were investigated.

Exploring spatiotemporal changes in the multi-granularity emotions of people in the city: a case study of Nanchang, China.

In the Internet age, emotions exist in cyberspace and geospatial space, and social media is the mapping from geospatial space to cyberspace. However, most previous studies pay less attention to the multidimensional and spatiotemporal characteristics of emotion. We obtained 211,526 Sina Weibo data with geographic locations and trained an emotion classification model by combining the Bidirectional Encoder Representation from Transformers (BERT) model and a convolutional neural network to calculate the emotional tendency of each Weibo.

Correction: Threading of three rings on two stations: a convergent approach to [4]rotaxane.

Correction for 'Threading of three rings on two stations: a convergent approach to [4]rotaxane' by Yidan Zhou , , 2021, , 13506-13509, DOI: 10.1039/D1CC05501A.

The Synergistic Reducing Drug Resistance Effect of Cisplatin and Ursolic Acid on Osteosarcoma through a Multistep Mechanism Involving Ferritinophagy.

Increasing evidence suggests that traditional Chinese medicine strategies are obviously beneficial for cancer treatment, but scientific research on the underlying molecular mechanisms is lacking. We report that ursolic acid, a bioactive ingredient isolated from Radix Actinidiae chinensis, has strong antitumour effects on osteosarcoma cells. Functional studies showed that ursolic acid inhibited tumour cell proliferation and promoted the apoptosis of a variety of osteosarcoma cells.

Study on the interactions between melamine-cored Schiff bases with cucurbit[]urils of different sizes and its application in detecting silver ions.

Three different complexes, TMeQ[6]-TBT, Q[7]-TBT, and Q[8]-TBT are constructed by three different cucurbiturils and synthesized by guest melamine-cored Schiff bases (TBT) through outer-surface interaction and host-guest interactions. TBT forms a TMeQ[6]-TBT complex with TMeQ[6] through outer-surface interaction, while Q[7]-TBT and Q[8]-TBT form complexes with Q[7,8] through host-guest interactions. Among them, Q[7]-TBT is selected as a UV detector for the detection of silver ions (Ag).

A Novel Spider Toxin Inhibits Fast Inactivation of the Na1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors.

Venomous animals have evolved to produce peptide toxins that modulate the activity of voltage-gated sodium (Na) channels. These specific modulators are powerful probes for investigating the structural and functional features of Na channels. Here, we report the isolation and characterization of δ-theraphotoxin-Gr4b (Gr4b), a novel peptide toxin from the venom of the spider Gr4b contains 37-amino acid residues with six cysteines forming three disulfide bonds Patch-clamp analysis confirmed that Gr4b markedly slows the fast inactivation of Na1.

Three-Dimensionally Printed Ti2448 With Low Stiffness Enhanced Angiogenesis and Osteogenesis by Regulating Macrophage Polarization Piezo1/YAP Signaling Axis.

Previous studies have found that the novel low-elastic-modulus Ti2448 alloy can significantly reduce stress shielding and contribute to better bone repair than the conventional Ti6Al4V alloy. In this study, the promotion of osteogenesis and angiogenesis by three-dimensionally printed Ti2448 were also observed . However, these were not significant in a series of tests.

Bioinspired functional SLIPSs and wettability gradient surfaces and their synergistic cooperation and opportunities for enhanced condensate and fluid transport.

Bioinspired smart functional surfaces have received increasing attention in recent years owed to their tunable wettability and enhanced droplet transport suggesting them as excellent candidates for industrial and nanotechnology-related applications. More specifically, bioinspired slippery lubricant infused porous surfaces (SLIPSs) have been proposed for their low adhesion enabling continuous dropwise condensation (DWC) even of low-surface tension fluids. In addition, functional surfaces with chemical and/or structural wettability gradients have also been exploited empowering spontaneous droplet transport in a controlled manner.

Rational Design and Porosity of Porous Alumina Ceramic Membrane for Air Bearing.

Air bearing has been widely applied in ultra-precision machine tools, aerospace and other fields. The restrictor of the porous material is the key component in air bearings, but its performance is limited by the machining accuracy. A combination of optimization design and material modification of the porous alumina ceramic membrane is proposed to improve performance within an air bearing.

Threading of three rings on two stations: a convergent approach to [4]rotaxane.

A novel approach to efficient and selective construction of [4]rotaxane was proposed to demonstrate the superiority of H-bonded azo-macrocycles in forging higher order rotaxanes. The single crystal structure reveals the importance of the interplay of multiple non-covalent bonding interactions, particularly π-stacking interactions, in stabilizing the host-guest complex. This may open an avenue to the synthesis of oligomeric mechanically interlocked molecules containing fewer stations but more rings.

Associations between COVID-19 related stigma and sleep quality among COVID-19 survivors six months after hospital discharge.

Background: Many COVID-19 survivors reported stigmatization after recovery. This study investigated the association between stigma (discrimination experiences, self-stigma and perceived affiliate stigma) and sleep quality among COVID-19 survivors six months after hospital discharge.

Methods: Participants were recovered adult COVID-19 survivors discharged between February 1 and April 30, 2020.

Spatial Analysis of Incidence of Diagnosed Type 2 Diabetes Mellitus and Its Association With Obesity and Physical Inactivity.

Objectives: To investigate the spatial distribution of 10-year incidence of diagnosed type 2 diabetes mellitus (T2DM) and its association with obesity and physical inactivity at a reginal level breakdown.

Methods: Demographic, behavioral, medical and pharmaceutical and diagnosed T2DM incidence data were collected from a cohort of 232,064 participants who were free of diabetes at enrolment in the 45 and Up Study, conducted in the state of New South Wales (NSW), Australia. We examined the geographical trend and correlation between obesity prevalence, physical inactivity rate and age-and-gender-adjusted cumulative incidence of T2DM, aggregated based on geographical regions.