Publications by authors named "Xin Xiang"

Current guidelines recommend psoriatic patients with latent tuberculosis infection undergo chemoprophylaxis prior to initiating any biologic. However, clinical studies indicate that interleukin (IL) inhibitors may not increase the risk of tuberculosis reactivation. This review evaluates the safety in psoriatic patients with latent tuberculosis infection using IL inhibitors without chemoprophylaxis.

View Article and Find Full Text PDF

Necrotizing soft tissue infections (NSTIs) are rare but life-threatening complications of colorectal cancer, often overlooked during patient diagnosis and treatment. NSTIs progress rapidly, leading to significant tissue damage and elevated mortality rates. This report presents the case of a 71-year-old male who presented with abdominal pain and distention, later diagnosed with perforated colon cancer and NSTI of the left abdominal wall.

View Article and Find Full Text PDF

Endometrial receptivity is vital for the successful implantation of embryos in sheep. Insufficient receptivity is a major cause of implantation failure, highlighting the need to understand the underlying mechanisms. MicroRNAs (miRNAs) play an essential role in the epigenetic regulation of endometrial receptivity and embryo implantation by influencing post-transcriptional processes.

View Article and Find Full Text PDF

Brown adipose tissue (BAT) is the primary site for non-shivering thermogenesis in the body and plays a crucial role in maintaining core body temperature. However, its function gradually declines with age. To mitigate the age-related decline in BAT thermogenic capacity, we treated progeroid mice with metformin to investigate the potential mechanisms by which metformin can slow the reduction in BAT thermogenic function.

View Article and Find Full Text PDF

A Gram-stain-positive, aerobic and non-motile actinobacterium, designated strain MR15.9, was isolated from sediment collected from a mangrove ecosystem in Semarang city, Indonesia. Strain MR15.

View Article and Find Full Text PDF

Background: Low back pain (LBP) is generally caused by lumbar degeneration without effective treatment. Lumbar degeneration is influenced by aberrant axial mechanical stress (MS), with facet joint osteoarthritis (FJOA) representing one of its primary pathological manifestations. MicroRNA (miRNA), functioning as an early intermediate in the transcription process, has frequently been demonstrated to serve as a critical mediator linking mechanical stress perception with cellular processes such as growth, development, aging, and apoptosis.

View Article and Find Full Text PDF

Spinal cord injury (SCI) is a catastrophic injury characterized by oxidative stress. Glutathione peroxidase 3 (GPx3) is an antioxidant enzyme that protects against immune responses in various diseases. However, the effects of GPx3 in SCI remains unclear.

View Article and Find Full Text PDF

Extensive agricultural regions commonly face issues of poor groundwater management, non-standard agricultural production practices, and unordered discharge of domestic pollution, leading to a continuous decline in groundwater quality and a sharp increase in risks. A comprehensive understanding of groundwater conditions and pollution is a crucial step in effectively addressing the water quality crisis. This study employs the Comprehensive Water Quality Index, Irrigation parameter, and Pollution Index to comprehensively investigate the groundwater quality in a typical agricultural area in Shandong, China, and assesses the suitability of groundwater for irrigation and the risks to human health.

View Article and Find Full Text PDF

The performance assessment of slopes during various disturbances is important to ensure the safe service of slopes. Due to the four characteristics of slope engineering, it is difficult for existing resilience evaluation models to accurately reflect slope performance. To address this problem, a resilience evaluation model applicable to slopes was developed in this study.

View Article and Find Full Text PDF

Background: Nonalcoholic steatohepatitis (NASH) has recently garnered increased attention due to immune infiltration. However, the role of membrane-associated protein 17 (MAP17) in NASH remains unclear, which prompted this study to explore its relationship with immune infiltration and its regulatory mechanisms.

Methods: We employed weighted correlation network analysis (WGCNA) to construct a gene co-expression network aimed at identifying key genes associated with NASH progression.

View Article and Find Full Text PDF

In clinical practice, there is a demand for innovative wound healing methods to tackle full thickness skin injuries, especially in those with diabetes. In this study, we examined if collagen-based hydrogel from amniotic membrane (CHAM) loaded with quercetin could enhance healing in diabetic rats. Sixty diabetic rats were randomly divided into the control group, CHAM group, quercetin group, and CHAM+Quercetin group.

View Article and Find Full Text PDF

Mine water influx is a significant geological hazard during mine development, influenced by various factors such as geological conditions, hydrology, climate, and mining techniques. This phenomenon is characterized by non-linearity and high complexity, leading to frequent water accidents in coal mines. These accidents not only impact coal production quality but also jeopardize the safety of mine staff.

View Article and Find Full Text PDF

Microwave phase detectors (MPDs) are key components of instantaneous frequency measurement (IFM) receivers and phase interferometer direction finding (PIF-DF) receivers. In conventional analyses, there is seldom a major quantitative discussion of MPD characterization when multiple signals arrive at the same time, which is often the case in complex and noisy electromagnetic environments. We have reanalyzed the characteristics of MPDs with respect to filter effects acting on more than two RF signals and differential amplifiers, which are not considered in conventional analyses.

View Article and Find Full Text PDF

The identification of novel bacterial species from the intestines of yaks residing on the Qinghai-Tibet Plateau is pivotal in advancing our understanding of host-microbiome interactions and represents a promising avenue for microbial drug discovery. In this study, we conducted a polyphasic taxonomic analysis and bioactive assays on a strain, designated Bos-x6-28, isolated from yak feces. The findings revealed that strain Bos-x6-28 shares a high 16S rRNA gene sequence similarity (98.

View Article and Find Full Text PDF

Rapid urbanization and industrialization in China have brought economic growth and improved living standards, while environmental degradation and resource overexploitation occurred simultaneously. Yellow River Basin (YRB) also faces priorities of ecological protection and high-quality development. Therefore, it is essential for YRB to coordinate the relationship between socioeconomic and eco-environment.

View Article and Find Full Text PDF

Lung cancer is the leading cause of cancer-related deaths globally. Despite recent improvements in incidence and mortality rates, the prognosis of lung cancer remains dire.F-FDG PET/CT plays a vital role in diagnosing, staging, and monitoring the therapeutic efficacy of lung cancer.

View Article and Find Full Text PDF

Background: Long noncoding RNA (lncRNA) is a significant component of the noncoding genome and refers to RNA molecules that exceed 200 nucleotides in length. It plays a crucial role in both promoting and suppressing cancer by regulating the proliferation, invasion, and metastasis of tumor cells. We have found a correlation between cancer susceptibility candidate 11 (CASC11) experssion and tumorigenesis development prognosis in a number of studies on tumors.

View Article and Find Full Text PDF

Hu sheep is an indigenous breed from the Taihu Lake Plain in China, known for its high fertility. Although Hu sheep belong to the Mongolian group, their demographic history and genetic architecture remain inconclusive. Here, we analyze 697 sheep genomes from representatives of Mongolian sheep breeds.

View Article and Find Full Text PDF

In this study, artificial neural network (ANN) and random forest (RF) were constructed to predict the Cd adsorption capacity of Fe-modified biochar. The RF model outperformed ANN model in accuracy and predictive performance (R = 0.98).

View Article and Find Full Text PDF

Soft tissue trauma can cause immune system disturbance and neuropathological invasion, resulting in heterotopic ossification (HO) due to aberrant chondrogenic differentiation of mesenchymal stem cells (MSCs). However, the molecular mechanisms behind the interaction between the immune and nervous systems in promoting HO pathogenesis are unclear. In this study, we found that mast cell-specific deletion attenuated localized tissue inflammation, with marked inhibition of HO endochondral osteogenesis.

View Article and Find Full Text PDF

Observational studies suggest a link between osteoarthritis (OA) and frailty, but the shared genetic architecture and causal relationships remain unclear. We analyzed X-ray and F-FDG PET/CT images in frail and non-frail individuals and conducted genetic correlation analyses using Linkage Disequilibrium Score Regression (LDSC) based on recent Genome-Wide Association Studies (GWAS) for OA and frailty. We identified pleiotropic single-nucleotide polymorphisms (SNPs) through Cross-Phenotype Association (CPASSOC) and Colocalization (COLOC) analyses and investigated genetic overlaps using Multi-marker Analysis of GenoMic Annotation (MAGMA).

View Article and Find Full Text PDF

Myxochelins are a group of catecholate siderophores encoded by biosynthetic gene clusters (BGCs). They are mainly produced by myxobacteria and display a wide variety of bioactivities. Herein, we report a group of new myxochelins produced not by a myxobacterial strain but by an actinobacteria strain, sp.

View Article and Find Full Text PDF
Article Synopsis
  • Generalized pustular psoriasis (GPP) is a severe skin disease that can be life-threatening, and spesolimab is an IL-36 receptor antibody showing promise for treating it, especially in adults, though data for children are limited.
  • The study involved five young patients (4-12 years old) who received a single dose of spesolimab, with significant improvements in their skin condition observed just one week later.
  • All patients showed decreased levels of key inflammatory markers and no recurrence of symptoms was noted after treatment, suggesting that spesolimab could be a potential treatment option for children with GPP.
View Article and Find Full Text PDF

Introduction: Observational studies have shown a bidirectional association between gastroesophageal reflux (GER) and chronic rhinosinusitis (CRS) or chronic rhinitis (CR), but it is not clear whether this association is causal.

Objectives: This study was to investigate the causality between GER and CRS or CR using bidirectional two-sample Mendelian randomization (MR) analysis.

Methods: Using pooled data from large genome-wide association studies (GWAS), genetic loci independently associated with GER, CRS and CR in populations of European and American ancestry were selected as instrumental variables (IVs).

View Article and Find Full Text PDF

Synopsis of recent research by authors named "Xin Xiang"

  • - Xin Xiang's recent research focuses on environmental health, particularly the implications of cyanotoxins such as Microcystin-LR on inflammatory bowel disease, underscoring the need for public health interventions in affected regions of China.
  • - Another significant area of Xiang's investigation involves the utilization of plant growth-promoting rhizobacteria to enhance drought tolerance in crops, which is critical for improving agricultural productivity amid climate change challenges.
  • - Additionally, Xiang explores health equity through studies on the impacts of health insurance reforms and diagnosis-related group payments in China, revealing disparities in healthcare access for rural residents and addressing the broader implications for health systems in low- and middle-income countries.

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessioniesm5mbkhv880fuarc9gvl4uv95rdp6u): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once