Concomitant use of sodium-glucose co-transporter 2 inhibitors and metformin and the risk of osteomyelitis reporting: a disproportionality analysis based on FAERS database.

Background: Recent clinical case reports have generated controversy concerning the adverse events (AEs) of amputation linked to sodium-glucose co-transporter 2 inhibitors (SGLT2i). We assessed the risk of osteomyelitis AE reporting linked to SGLT2i or SGLT2i-metformin co-medication.

Research Design And Methods: Investigated the FDA Adverse Event Reporting System for osteomyelitis-related AEs associated with SGLT2i or SGLT2i-metformin co-medication from 2013q2 to 2023q1.

Genome sequence of the Mediterranean red coral Corallium rubrum.

Objectives: Corallium rubrum, the precious red coral, is an octocoral endemic to the western Mediterranean Sea. Like most octocorals, it produces tiny, calcified structures called sclerites. Uniquely, it also produces a completely calcified axial skeleton that is a bright red color.

Multidimensional perspectives on nurse burnout in China: a cross-sectional study of subgroups and predictors.

Background: Burnout is a state of physical and mental exhaustion triggered by long-term work stress, which is manifested mainly as emotional exhaustion, depersonalization, and a decreased sense of accomplishment. Among them, emotional exhaustion is its core feature, which often leads to a significant decrease in an individual's enthusiasm for work. Owing to the high intensity of the work environment and the special requirements of emotional labor, the nursing community is more vulnerable to burnout.

DCSENets: Interpretable deep learning for patient-independent seizure classification using enhanced EEG-based spectrogram visualization.

Neurologists often face challenges in identifying epileptic activities within multichannel EEG recordings, requiring extensive hours of analysis. Computer-aided diagnosis systems have been proposed to reduce manual inspection of EEG signals by neurologists. However, direct analysis of EEG signals is difficult due to their complex and dynamic nature, with variation across multiple patients.

Gelatin/polycaprolactone membranes promote endometrial regeneration and restore fertility.

Objective: To investigate the effectiveness of gelatin/polycaprolactone (GT/PCL) membranes for restoring endometrial structure and function and fertility in a rat model of endometrial injury.

Methods: We randomized 125 female Sprague-Dawley (SD) rats to the sham, natural repair (NR), estrogen (E), GT/PCL, and E-GT/PCL groups. Except for the sham group, all rats underwent uterine curettage.

Genome of root celery and population genomic analysis reveal the complex breeding history of celery.

Celery (Apium graveolens L.) is an important vegetable crop in the Apiaceae family. It comprises three botanical varieties: common celery with solid and succulent petioles, celeriac or root celery with enlarged and fleshy hypocotyls and smallage or leaf celery with slender, leafy and usually hollow petioles.

Effect of traction therapy on muscle satellite cell proliferation and differentiation in a rat model of knee stiffness.

Background: In the rat knee stiffness model, the duration of traction treatment is mostly 20-40 min; however, relatively few studies have been conducted on longer traction treatment of extended knee stiffness in rats. Therefore, the aim of this study was to explore the efficacy of prolonged traction and its mechanism of action in extended knee stiffness in rats.

Methods: The model of extended knee joint stiffness was established in rats and treated with powered flexion position traction.

Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation.

Background: Functional mitral regurgitation (MR) is a common form of mitral valve dysfunction that often persists even after surgical intervention, requiring reoperation in some cases. To advance our understanding of the pathogenesis of functional MR, it is crucial to characterize the cellular composition of the mitral valve leaflet and identify molecular changes in each cell subtype within the mitral valves of MR patients. Therefore, we aimed to comprehensively examine the cellular and molecular components of mitral valves in patients with MR.

Targeting PTGDS Promotes ferroptosis in peripheral T cell lymphoma through regulating HMOX1-mediated iron metabolism.

Background: Peripheral T cell lymphoma (PTCL) is characterized by high heterogeneity, strong aggressiveness, and extremely poor prognosis. Ferroptosis, a novel form of programmed cell death, has been involved in tumor development and targeting ferroptosis holds great potential for tumor therapy.

Methods: Lentiviral transfection was performed to regulate gene expression, followed by Tandem mass tag (TMT)-mass spectrometry and RNA-sequencing.

Investigation of the gastric digestion behavior of commercial infant formulae using an dynamic infant digestion model.

The gastric digestion behavior of different commercial Stage 1 infant formulae (for 0-6 months) with different formulation backgrounds was investigated using an dynamic infant human gastric simulator (iHGS). The microstructural arrangements of the protein and lipid, colloidal stability and protein hydrolysis during digestion were elucidated. During gastric digestion, casein-dominant formulations showed a higher extent of aggregation due to their high proportion of casein micelles that underwent coagulation upon acidification and via the action of pepsin.

A Novel Neuroprotective Derived Peptide of Erythropoietin Improved Cognitive Function in Vascular Dementia Mice.

The effective therapeutics for vascular dementia are still lacking. Here, we designed a novel derived peptide of erythropoietin-DEPO and evaluated its safety, erythropoiesis effect, and neuroprotective effects in mice of vascular dementia. For evaluating the safety and erythropoiesis, DEPO was injected into naive C57BL6 mice (n = 5) for 4-8 weeks, and venous blood was collected at 1, 2, and 4 weeks after DEPO treatment.

Mir-615-3p promotes osteosarcoma progression via the SESN2/AMPK/mTOR pathway.

Background: Osteosarcoma (OS) is the most common primary malignant bone neoplasm. Growing researches have highlighted the tumor promoting role of miR-615-3p in various cancers. Notwithstanding, the biological function and underlying mechanisms of miR-615-3p in OS development still unclear.

Situational leadership theory in nursing management: a scoping review.

Aim: To provide a comprehensive overview of situational leadership theory as applied to nursing management, outlining its relevant measurement tools, intervention modalities, and reporting gaps.

Design: A scoping review of the literature was conducted according to the JBI guidelines.

Data Sources: Eight databases were used including PubMed, Embase, CINHAL, Web of Science, CNKI, WanFang, Cqvip, SinoMed.

Mechanism of RBM15 in the malignant proliferation of colorectal cancer cells through regulating the stability of LncRNA FGD5-AS1 via m6A modification.

Colorectal cancer (CRC) is the third most prevalent cancer all around the world. This study explored the mechanism of RBM15-mediated m6A modification in CRC cell malignant proliferation. The expression of RBM15, LncRNA FGD5-AS1, and HOXC10 was detected in CRC cells.

Genome-wide analysis of the laccase gene family in Arachis hypogaea and functional characterization of AhLAC63 involved in lignin biosynthesis and abiotic stress.

Plant laccases (LACs) play a vital role in lignification and participate in multiple biotic/abiotic stress responses. However, little is known about their role in lignin deposition and stress resistance in cultivated peanut (Arachis hypogaea L.).

Significant association between three atherosclerosis indexes and stroke risk.

Background: To evaluate the associations of three atherosclerosis indexes with stroke in a population aged 65 years and older.

Methods: A sample was obtained from wave 2011 to wave 2015 of the China Health and Retirement Longitudinal Study. Multivariate logistic regression models were used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for stroke in the quartiles of three atherosclerosis indexes, and restricted cubic splines were constructed.

Nurses' job embeddedness and turnover intention: A systematic review and meta-analysis.

Objective: This study aimed to review the relationship between job embeddedness and turnover intentions among nurses and explore the effects of the Job Embeddedness Scale, number of years in the career, education, and marital status on this relationship.

Methods: The review was conducted by searching the China Knowledge Resource Integrated Database (CNKI), Weipu Database (CQVIP), China Biology Medicine (CBM), Wanfang Database, PubMed, Web of Science, Embase, CINAHL, and APA-PsycNet for articles on nurses' job embeddedness and turnover from intention up to March 2024. The research quality was evaluated using the Agency for Healthcare Research and Quality (AHRQ) assessment criteria.

Characterization and Implications of the Regionally Prevalent ST8333 Strains of Serotype 4,[5],12:i: - China, 2017-2023.

What Is Already Known About This Topic?: is a significant foodborne pathogen responsible for millions of infections and thousands of deaths worldwide each year. The increasing prevalence of the ST34 serotype 4,5,12:i:-(. 4,[5],12:i:-) poses a substantial public health threat in China.

Exploring the relationship between gut microbiota and breast diseases using Mendelian randomization analysis.

Background: Growing evidence suggests a relationship between gut microbiota composition and breast diseases, although the precise nature of this association remains uncertain. To investigate the causal relationship between gut microbiota and breast diseases, we utilized two-way Mendelian randomization (MR) analysis.

Methods: Four common diseases were included as outcomes: breast cancer, breast cysts, inflammatory disorders of the breast, and infections of the breast associated with childbirth, along with their subtypes.

Metabolomic studies reveal and validate potential biomarkers of diabetic retinopathy in two Chinese datasets with type 2 diabetes: a cross-sectional study.

Background: Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus and causes vision impairment and blindness. The presence of major risk factors for DR, such as high levels of HbA1c, does not predict all DR pathogenesis in the clinic, which suggests that uncovering the underlying mechanisms and identifying novel markers are needed. Previous evidence has shown that the serum metabolic signature of DR is unique and detectable compared with that of diabetes mellitus (DM).

Temperature induces brain-intake shift of recombinant high-density lipoprotein after traumatic brain injury.

Traumatic brain injury (TBI) is one of the leading public health concerns in the world. Therapeutic hypothermia is routinely used in severe TBI, and pathophysiological hyperthermia, frequently observed in TBI patients, has an unclear impact on drug transport in the injured brain due to a lack of study on its effects. We investigated the effect of post-traumatic therapeutic hypothermia at 33°C and pathophysiological hyperthermia at 39°C on brain transport and cell uptake of neuroprotectants after TBI.

Psychometric properties of the Wijma Delivery Expectancy/Experience Questionnaire version A among Chinese expectant fathers.

Background: Evidence on the mental status of expectant fathers indicates that their fears of childbirth (FOC) are of great concern. In consideration of expectant fathers' increasing involvement during pregnancy and childbirth, it is necessary to provide a reliable instrument to measure the psychometric properties of expectant fathers. The purpose of this study was to revise the Wijma Delivery Expectancy/Experience Questionnaire version A (W-DEQ A) for expectant fathers, analyze the psychometric properties and explore its applicability to the Chinese population.

Interfacial Engineering to Fabricate Nanoporous FeMo Bimetallic Nitride for Enhanced Electrochemical Ammonia Synthesis.

The electrochemical N reduction reaction (NRR) currently represents a green and sustainable approach to ammonia production. However, the further progress of NRR is significantly hampered by poor catalytic activity and selectivity, necessitating the development of efficient and stable electrocatalysts. Herein, a nanoporous Fe-Mo bimetallic nitride (FeN-MoN) is synthesized using a molten-salt preparation method.

Targeting piRNA-137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via De Novo Cholesterol Biosynthesis in Lung Adenocarcinoma.

The important role of PIWI-interacting RNAs (piRNAs) in tumors has garnered increasing attention. However, research on their role in lung adenocarcinoma (LUAD) remains limited. Elevated levels of piRNA-137463 have been linked to poor prognosis in LUAD patients.