Soil depth exerts greater effect on bacterial community than spatial structure in Longmenshan fault zone.

Unlabelled: The diversity patterns and drivers of soil microbial communities across spatial distances have been extensively investigated over the recent years. However, whether microbial communities in surface and subsurface soils showed an identical spatial distribution pattern at a small regional scale has not been fully confirmed. For this, we investigated the linkage between soil water content (SWC), pH as well as nutrient contents and soil bacterial diversity and communities in different soil layers in the Longmenshan fault zone in Sichuan Province, China.

Remote ischaemic pre-conditioning, kidney injury, and outcomes after coronary angiography and intervention: a randomized trial.

Background And Aims: Remote ischaemic pre-conditioning (RIPC) delivered shortly prior to an angiographic procedure may reduce contrast-associated acute kidney injury (CA-AKI). Whether a longer interval between RIPC and contrast administration also reduces CA-AKI and post-procedural complications after coronary angiography (CAG) or percutaneous coronary intervention (PCI) is unknown.

Methods: This was a multicentre, randomized trial of patients at risk of CA-AKI undergoing elective CAG or PCI comparing delayed RIPC (four cycles of 5 min inflations on one upper arm 24 h before the procedure) with sham RIPC.

LINC00461 SNPs rs933647 and rs201864123 modify the risk of adenoid hypertrophy susceptibility for children in South China.

Background: Adenoidal hypertrophy (AH) is commonly observed in childhood and closely linked to obstructive sleep apnea (OSA). Despite the high prevalence of AH, its pathophysiological mechanisms remain incompletely understood. We attempt to explore this issue from a genetic perspective.

Mitochondrial Amount Determines Doxorubicin-Induced Cardiotoxicity in Cardiomyocytes.

Doxorubicin, an anthracycline commonly used for treating cancer patients, is known for its cardiotoxic side-effects. Although dose-dependent, but susceptibility remains variable among patients, and childhood-exposure-adult-onset remains challenging. Besides topoisomerase toxicity, Doxorubicin is also toxic to the mitochondria yet the underlying late onset mechanism remains elusive.

Characteristics and associations between sexting and high-risk sexual behaviors among college students in Jiangxi Province, China.

Background To explore the characteristics, influencing factors, and associations between sexting and high-risk sexual behaviors among college students in Jiangxi Province, China, providing a basis for promoting sexual health education and preventing high-risk sexual behaviors among college students. Methods A convenient sampling method was used to conduct an anonymous survey on 13,976 students from 15 universities in Jiangxi Province from November to December 2023. Chi-squared tests and binary logistic regression analyses were employed to investigate the influencing factors and associations between sexting and high-risk sexual behaviors.

A temporal-spatial feature fusion network for emotion recognition with individual differences reduction.

Purpose: In the context of EEG-based emotion recognition tasks, a conventional strategy involves the extraction of spatial and temporal features, subsequently fused for emotion prediction. However, due to the pronounced individual variability in EEG and the constrained performance of conventional time-series models, cross-subject experiments often yield suboptimal results. To address this limitation, we propose a novel network named Time-Space Emotion Network (TSEN), which capitalizes on the fusion of spatiotemporal information for emotion recognition.

Sacubitril/Valsartan for Blood Pressure Lowering in Non-Dialysis-Dependent Chronic Kidney Disease Stage 3-5 Patients With Hypertension: A Multicenter Clinical Study.

To assess the effectiveness and safety of Sacubitril/Valsartan in reducing blood pressure in individuals with non-dialysis-dependent chronic kidney disease (NDD-CKD) Stage 3-5 complicated by hypertension. This study was a multicenter retrospective analysis conducted from March 1, 2022 to March 31, 2024, involving adult patients with NDD-CKD Stage 3-5 and hypertension, who received Sacubitril/Valsartan either as a monotherapy or in addition to current antihypertensive treatments that were insufficient. The main outcomes measured were blood pressure control, changes in blood pressure and laboratory parameters within 8 weeks post-treatment initiation, and incidence of adverse events.

Dry-Solid-Electrochemical Synthesis: A General Method for Large Scale Synthesis of Single-Atom Catalysts with High Metal loadings.

Single-atom catalysts (SACs) with high metal loadings are highly desirable but still challenging for large scale synthesis. Here we report a new technique named as dry-solid-electrochemical synthesis (DSES) for a general large-scale synthesis of SACs with high metal loadings in an energy-conservation and environment-friendly way. With it, a series of pure carbon-supported metal SACs (Platinum up to 35.

SiCLAT: simultaneous imaging of chromatin loops and active transcription in living cells.

We present SiCLAT, which introduces a dCas9-dCas13d cassette into the mouse genome. This model enables the stable expression of both dCas9 and dCas13 proteins in diverse cell populations, facilitating concurrent labeling of DNA and RNA across various cell types. Using SiCLAT, we accurately labeled chromatin loop anchor interactions and associated gene transcription during myogenic differentiation.

A Machine Learning-Based Prediction Model for Acute Kidney Injury in Patients With Community-Acquired Pneumonia: Multicenter Validation Study.

Background: Acute kidney injury (AKI) is common in patients with community-acquired pneumonia (CAP) and is associated with increased morbidity and mortality.

Objective: This study aimed to establish and validate predictive models for AKI in hospitalized patients with CAP based on machine learning algorithms.

Methods: We trained and externally validated 5 machine learning algorithms, including logistic regression, support vector machine, random forest, extreme gradient boosting, and deep forest (DF).

Association of serum klotho level with albuminuria in middle‑aged and elderly participants without diabetes mellitus: a cross‑sectional study.

Background: The relationship between serum klotho level and albuminuria is unknown in middle-aged and elderly participants without diabetes mellitus (DM). Therefore, we will investigate the association between serum klotho level and albuminuria in middle-aged and elderly participants without DM.

Methods: Participants (aged 40-79) were from the five continuous cycles (2007-2016) of the National Health and Nutrition Examination Survey (NHANES).

Curcumin: Epigenetic Modulation and Tumor Immunity in Antitumor Therapy.

Curcumin is the main ingredient of the Chinese herbal turmeric rhizome, used to treat tumors, diabetes, inflammation, neurodegenerative diseases, cardiovascular diseases, metabolic syndrome, and liver diseases. The antitumor effects of curcumin have received even more attention. One of the main mechanisms of antitumor effects includes inhibition of tumor invasion and migration, induction of tumor cell apoptosis, and inhibition of various cell signaling pathways.

Effect of continuous esketamine infusion on brain white matter microstructure in patients with major depression: A diffusion tensor imaging study.

Introduction: Esketamine has demonstrated acute antidepressant effects in patients with major depressive disorder (MDD). This study investigated whether these effects associate with reversible white matter fiber integrity recovery using diffusion imaging.

Method: Twenty patients with MDD and 20 healthy controls received 2-week esketamine treatment.

Selective Hydrogen Oxidation Catalyst for PEM Fuel Cells: Tungsten Cluster-Tuned Platinum Single Atoms.

The selective hydrogen oxidation reaction (HOR) electrocatalyst is crucial for enhancing the performance of proton-exchange membrane fuel cells (PEMFCs) against degradation caused by reverse currents. In this study, a catalyst comprising platinum single atoms (Pt) finely tuned by tungsten nanoclusters (W) on an accordion-like nitrogen-doped carbon support (ANC) is presented. The tungsten nanoclusters, derived from phosphotungstic acid, are embedded within the carbon support, while the Pt single atoms are uniformly dispersed on its surface.

Interplay and long-lasting effects of maternal low-level Pb, Hg, and Cd exposures on offspring cognition.

Lead (Pb), mercury (Hg), and cadmium (Cd) are prevalent and persistent environmental contaminants, causing detrimental effects on millions of individuals worldwide. Our previous research demonstrated that early-life exposure to low-level Pb, Hg, and Cd mixtures may lead to cognitive impairments. However, the association and interaction among low levels of Pb, Hg, or Cd exposure remains unclear.

Evolution of Nitrogen-Coordinated Metal Single Atoms Toward Single-Atom Alloys on MgH₂ as Efficient and Stable Hydrogen Spillover Catalysts.

M-N-C catalysts with nitrogen-coordinated metal single-atom active sites have demonstrated high activity for hydrogen storage materials, but their stability in this application remains uncertain. This study addresses this issue by using nickel phthalocyanine (NiPc) molecules on MgH₂ particles as a model system. It is found that the N-coordinated high-valence Ni single atoms in the NiN₄ active site are unstable in the reducing environment of hydrogen storage, spontaneously evolving into zero-valence Ni, forming a Ni₁-Mg single-atom alloy (SAA).

Boosting the Performance and Durability of Fe-N-C Fuel Cell Catalysts via Integrating MoC Clusters.

Carbon-supported nitrogen-coordinated iron single-atom (Fe-N-C) catalysts have been regarded among the most promising platinum-group-metal-free catalysts for oxygen reduction reaction (ORR) in proton exchange membrane fuel cells (PEMFCs). Nevertheless, their limited intrinsic activity and unsatisfactory stability have hindered their practical applications. Here, it is reported that the integration of MoC clusters effectively enhances the ORR activity and stability of Fe-N-C catalysts.

Corrigendum: Effectiveness, safety, and treatment pattern of sodium zirconium cyclosilicate in Chinese patients with hyperkalemia: interim analysis from a multicenter, prospective, real-world study (Actualize Study).

[This corrects the article DOI: 10.3389/fphar.2024.

Ulinastatin attenuates renal ischemia-reperfusion injury by inhibiting NLRP3 inflammasome-triggered pyroptosis.

Systemic inflammation is involved in developing acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB). Ulinastatin, a urinary trypsin inhibitor (UTI), has various anti-inflammatory effects. Our previous data displayed that UTI administration during CPB played a protective role in reducing the risk of AKI after cardiac surgery; however, its role in AKI pathogenesis remains unknown.

Tailoring Oxygen Reduction Reaction on M-N-C Catalysts via Axial Coordination Engineering.

The development of fuel cells and metal-air batteries is an important link in realizing a sustainable energy supply and a green environment for the future. Oxygen reduction reaction (ORR) is the core reaction of such energy conversion devices. M-N-C catalysts exhibit encouraging ORR catalytic activity and are the most promising candidates for replacing Pt/C.

A bibliometric and knowledge-map analysis of psychological violence from 2003 to 2022.

Background: Psychological violence is a serious global public health and social issue, attracting increasing research. Its adverse effects on individuals and society are significant. Given the negative impacts of psychological violence and the importance of maintaining mental health, we employed a bibliometric analysis of the literature on psychological violence over the past 20 years on a global scale.