Versatile Tunable Terahertz Absorption Device Based on Bulk Dirac Semimetals and Graphene.

We employed the CST Microwave Studio software 2020 and the FDID algorithm for simulation. We have designed a terahertz broadband absorber based on Dirac semimetals and graphene, achieving continuous broadband absorption with a rate exceeding 80% over the range from 7.6776 to 9.

Robust Assessments of Lithium Mining Impacts Embodied in Global Supply Chain Require Spatially Explicit Analyses.

Lithium is a critical material for the energy transition, but its mining causes significant environmental impacts that will intensify due to surging global demand. Here, we conduct a mining site-specific environmental impact assessment of lithium on a global scale, focusing on greenhouse gas (GHG) emissions, water use, and land use. We then track the production and international trade flows of all lithium-containing commodities to assess how lithium mining impacts are distributed across global supply chains.

Structural insights and therapeutic potential of plant-based pectin as novel therapeutic for type 2 diabetes mellitus: A review.

Type 2 diabetes mellitus (T2DM) is a global health challenge with limited efficacy of current treatments, necessitating alternative therapies. Plant-derived pectin, composed of galacturonic acid and structural domains such as homogalacturonan, has shown promise as an anti-diabetic agent. Pectin exerts its therapeutic effects through multiple mechanisms, including enhancing β-cell function, regulating glucose metabolism, improving insulin sensitivity, inhibiting digestive enzymes, and restoring gut microbiota balance.

How to improve users' purchase intention of agricultural products through live streaming systems?

With the development and improvement of technology, live streaming systems have emerged in people's daily lives, providing new channels for agricultural product sales. This study aims to understand how to scientifically design live streaming systems for agricultural product sales based on user perceptions and preferences. We conducted an online survey, and Study 1 obtained 569 valid samples.

Regulation of lung cancer initiation and progression by the stem cell determinant Musashi.

Despite advances in therapeutic approaches, lung cancer remains the leading cause of cancer-related deaths. To understand the molecular programs underlying lung cancer initiation and maintenance, we focused on stem cell programs that are normally extinguished with differentiation but can be reactivated during oncogenesis. Here, we have used extensive genetic modeling and patient-derived xenografts (PDXs) to identify a dual role for Msi2: as a signal that acts initially to sensitize cells to transformation, and subsequently to drive tumor propagation.

The clinical study of high-intensity focused ultrasound for the treatment of 160 cases of postpartum placenta increta.

Purpose: To investigate the safety and efficacy of high-intensity focused ultrasound (HIFU) in the treatment of postpartum placenta increta and to analyze the influencing factors of intraoperative blood loss and curettage times.

Methods: From January 2016 to December 2018, a retrospective analysis was conducted on 160 patients with placenta increta treated by HIFU combined with (or without) curettage in our hospital. Intraoperative blood loss and the number of curettage procedures were recorded.

Deep-Learning-Based Approaches for Rational Design of Stapled Peptides With High Antimicrobial Activity and Stability.

Antimicrobial peptides (AMPs) face stability and toxicity challenges in clinical use. Stapled modification enhances their stability and effectiveness, but its application in peptide design is rarely reported. This study built ten prediction models for stapled AMPs using deep and machine learning, tested their accuracy with an independent data set and wet lab experiments, and characterised stapled loop structures using structural, sequence and amino acid descriptors.

Resveratrol in animal models of pancreatitis and pancreatic cancer: A systematic review with machine learning.

Background: Resveratrol (RES), a common type of plant polyphenols, has demonstrated promising therapeutic efficacy and safety in animal models of pancreatitis and pancreatic cancer. However, a comprehensive analysis of these data is currently unavailable. This study aimed to systematically review the preclinical evidence regarding RES's effects on animal models of pancreatitis and pancreatic cancer via meta-analyses and optimised machine learning techniques.

Neural processing of children's theory of mind in a naturalistic story-listening paradigm.

Theory of mind (ToM) refers to our understanding of people's mental states. This ability develops in childhood and influences later social life. However, neuroimaging of ToM in young children often faces challenges in ecological validity and quality data collection.

Pharmacological Interventions for Acute Pancreatitis in Adults: An Overview of Systematic Reviews.

Aim: To provide a comprehensive assessment of the efficacy and safety of pharmacological interventions for AP.

Methods: This was an overview of systematic reviews based on randomized controlled trials comparing pharmacological interventions with placebo or blank control in adults with AP. We searched PubMed, Embase, and the Cochrane Database of Systematic Reviews from inception to January 13, 2024, with an update on February 4, 2025.

Characteristics of Cerebral Autoregulation After Mechanical Thrombectomy and Its Relationship With Prognosis.

Aims: To investigate the characteristics of dynamic cerebral autoregulation (dCA) in patients after mechanical thrombectomy (MT) and the relationship between dCA and prognosis.

Methods: In this prospective study, 89 and 158 patients were enrolled in the MT and non-MT groups, respectively. Both groups underwent dCA measurements within 3 days after stroke.

SIRT3 deficiency reduces PFKFB3-driven T-cell glycolysis and promotes arthritic inflammation.

Cell metabolism is an indispensable biochemical process that provides the basic energy and materials necessary for normal cell function. Accumulating evidence implicates abnormal metabolism of T cells as playing a critical role in the pathogenesis of rheumatoid arthritis (RA). The deacetylase SIRT3 has been shown to directly regulate energy metabolism in nonimmune cells.

Older Lineages of Oribatid Mites in Mountain Ranges Have Broader Geographic Ranges and Exhibit More Generalistic Traits.

Understanding ecological and evolutionary mechanisms that drive biodiversity patterns is important for comprehending biodiversity. Despite being critically important to the functioning of ecosystems, the mechanisms driving belowground biodiversity are little understood. We investigated the radiation and trait diversity of soil oribatid mites from two mountain ranges, that is, the Alps in Austria and Changbai Mountain in China, at similar latitude in the temperate zone differing in formation processes (orogenesis) and exposed to different climates.

The anti-inflammatory effects of saponins from natural herbs.

Inflammation is a protective mechanism that also starts the healing process. However, inflammatory reaction may cause severe tissue damage. The increased influx of phagocytic leukocytes may produce excessive amount of reactive oxygen species, which leads to additional cell injury.

Harnessing spinal circuit reorganization for targeted functional recovery after spinal cord injury.

Spinal cord injury (SCI) disrupts the communication between the brain and spinal cord, resulting in the loss of motor function below the injury site. However, spontaneous structural and functional plasticity occurs in neural circuits after SCI, with unaffected synaptic inputs forming new connections and detour pathways to support recovery. The review discusses various mechanisms of circuit reorganization post-SCI, including supraspinal pathways, spinal interneurons, and spinal central pattern generators.

MYRF is Essential in Mesothelial Cells to Promote Lung Development and Maturation.

The mesothelium is a squamous monolayer that ensheathes internal organs, lines the body cavity, and the diaphragm. It serves as a protective barrier, coated in glycocalyx, and secretes lubricants to facilitate tissue movement. How the mesothelium forms is poorly understood.

Nanoconfinement Effects in Electrocatalysis and Photocatalysis.

Recently, the enzyme-inspired nanoconfinement effect has garnered significant attention for enhancing the efficiency of electrocatalysts and photocatalysts. Despite substantial progress in these fields, there remains a notable absence of comprehensive and insightful articles providing a clear understanding of nanoconfined catalysts. This review addresses this gap by delving into nanoconfined catalysts for electrocatalytic and photocatalytic energy conversion.

Yiqi Jianpi Kangai Decoction Enhances the Chemotherapy Effect by Inducing Apoptosis and Regulating Treg and Th17 Cells in Colorectal Cancer Mice Model with Spleen Qi Deficiency.

Background: Colorectal Cancer (CRC) is widely prevalent worldwide and its incidence is increasing. Chemotherapy is an important treatment method for colorectal cancer in addition to surgery, but it often causes physical and mental pain to patients due to its side effects. TCM emphasizes evidence-based treatment and a holistic concept, and the combination of TCM and chemotherapy can reduce chemotherapy side effects, improve chemotherapy efficacy, and enhance patients' immunity.

Pioneering ionic liquids in neuro-soothing: Enhanced transdermal delivery of collagen peptides and their synergistic anti-aging functions.

Facial wrinkles include static and dynamic lines formed through different mechanisms and require diverse treatment approaches. Peptides perform well in anti-aging and wrinkle removal but exhibit poor transdermal efficiency. In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA) and lactic acid (LA), is applied in the transdermal delivery of hexapeptide-9, which promotes collagen production.

A nomogram for predicting contralateral femoral head collapse after unilateral replacement of bilateral femoral head necrosis.

This study aimed to develop and validate a nomogram, which can effectively predict the risk of contralateral asymptomatic femoral head collapse in patients with bilateral osteonecrosis of the femoral head (ONFH), undergoing unilateral total hip arthroplasty (THA). We retrospectively analyzed the clinical data of patients who underwent unilateral THA for bilateral non-traumatic ONFH in our center from 2015 to 2018. A total of 103 patients participated in at least 5 years of follow-up.

Development and Validation of Mouse Models for Studying Genital Tract Infection Pathogenesis.

Animal infection models play significant roles in the study of bacterial pathogenic mechanisms and host-pathogen interactions, as well as in evaluating drug and vaccine efficacies. is responsible for infections in various mucosal tissues, including the eyes and urogenital, respiratory, and gastrointestinal tracts. Chronic infections can result in severe consequences such as trachoma-induced blindness, ectopic pregnancy, and infertility.

Unraveling the promotion for SO and HO resistance of transition metal-doped CeO-TiO catalysts in NH-SCR reaction: A DFT study.

SO and HO can cause severe deactivation of CeO-TiO catalysts for NH-SCR reaction. Transition metal doping is an effective method to improve the SO and HO resistance of CeO-TiO catalysts. In this study, five transition metals (W, Nb, Mo, Fe, Mn) were selected as doped elements for the CeO-TiO catalysts.

A realworld pharmacovigilance study of trazodone based on the FDA adverse event reporting system.

To explore and analyze the potential adverse event (AE) signals of trazodone, with reference to the safe clinical use of drugs. Based on the FDA Adverse Event Reporting System (FAERS), the AE data of trazodone were extracted from the first quarter of 2004 to the second quarter of 2024, and the extracted data were statistically analyzed using the method, to identify valid AE signals that met our judgment, compare them with those recorded in the authorized information for trazodone thereby identifying unexpected potential adverse reactions. A total of 5199 AE reports with trazodone as the main suspect were extracted, with a higher reported proportion of females (52.

Protective effects of Colla Corii Asini Collagen Peptides on D-galactose injection combined with UVB irradiation-induced aging in mice.

Skin aging, autonomic mobility, memory function and physical deterioration are important features of aging, and effective anti-aging treatments are important in slowing down these processes. The objective of this research was to evaluate the protective effect of Colla Corii Asini (Ejiao) Collagen Peptides (CCACPs) on D-galactose (D-gal) injection combined with UV irradiation-induced senescence in mice. BY-HEALTH collagen oral solution (Bcos) was used as a positive control.