Plant Functional Groups Dominate Responses of Plant Adaptive Strategies to Urbanization.

Urbanization causes alteration in atmospheric, soil, and hydrological factors and substantially affects a range of morphological and physiological plant traits. Correspondingly, plants might adopt different strategies to adapt to urbanization promotion or pressure. Understanding of plant traits responding to urbanization will reveal the capacity of plant adaptation and optimize the choice of plant species in urbanization green.

A hierarchical bilayer architecture for complex tissue regeneration.

Engineering a complete, physiologically functional, periodontal complex structure remains a great clinical challenge due to the highly hierarchical architecture of the periodontium and coordinated regulation of multiple growth factors required to induce stem cell multilineage differentiation. Using biomimetic self-assembly and microstamping techniques, we construct a hierarchical bilayer architecture consisting of intrafibrillarly mineralized collagen resembling bone and cementum, and unmineralized parallel-aligned fibrils mimicking periodontal ligament. The prepared biphasic scaffold possesses unique micro/nano structure, differential mechanical properties, and growth factor-rich microenvironment between the two phases, realizing a perfect simulation of natural periodontal hard/soft tissue interface.

Prevalence of Multimorbidity of Chronic Noncommunicable Diseases in Brazil: Population-Based Study.

Background: Multimorbidity is the co-occurrence of two or more chronic diseases.

Objective: This study, based on self-reported medical diagnosis, aims to investigate the dynamic distribution of multimorbidity across sociodemographic levels and its impacts on health-related issues over 15 years in Brazil using national data.

Methods: Data were analyzed using descriptive statistics, hypothesis tests, and logistic regression.

Comprehensive Analysis of N6-Methyladenosine RNA Methylation Regulators Expression Identify Distinct Molecular Subtypes of Myocardial Infarction.

Myocardial infarction (MI) is one of the leading threats to human health. N6-methyladenosine (m6A) modification, as a pivotal regulator of messenger RNA stability, protein expression, and cellular processes, exhibits important roles in the development of cardiac remodeling and cardiomyocyte contractile function. The expression levels of m6A regulators were analyzed using the GSE5406 database.

Systematic Review and Network Meta-Analysis of Noninvasive Brain Stimulation on Dysphagia after Stroke.

Background: Dysphagia is a common sequelae after stroke. Noninvasive brain stimulation (NIBS) is a tool that has been used in the rehabilitation process to modify cortical excitability and improve dysphagia.

Objective: To systematically evaluate the effect of NIBS on dysphagia after stroke and compare the effects of two different NIBS.

Optimal Course of Statins for Patients With Aneurysmal Subarachnoid Hemorrhage: Is Longer Treatment Better? A Meta-Analysis of Randomized Controlled Trials.

Statins are used in clinical practice to prevent from complications such as cerebral vasospasm (CVS) after aneurysmal subarachnoid hemorrhage (aSAH). However, the efficacy and safety of statins are still controversial due to insufficient evidence from randomized controlled trials and inconsistent results of the existing studies. This meta-analysis aimed to systematically review the latest evidence on the time window and complications of statins in aSAH.

Dietary omega-3 polyunsaturated fatty acids and fish intake and risk of age-related macular degeneration.

Background & Aims: Epidemiologic studies are inconsistent regarding the association of dietary omega-3 polyunsaturated fatty acids (PUFA) and/or fish intake with risk of age-related macular degeneration (AMD) incidence and progression. The objective was to determine these associations by conducting a meta-analysis of available studies.

Methods: Three electronic databases were searched for studies that quantified dietary omega-3 PUFA and/or fish intake from inception to December 2020 without language restriction.

A needle tip CCEA microfluidic device based on enhanced Dean flow for cell washing.

Particle/cell washing is an essential technique in biological and clinical manipulations. Herein, we propose a novel circular contraction-expansion array (CCEA) microdevice. It can be directly connected to a needle tip without connection tubes.

LncRNA TLR8-AS1 suppresses miR-34a maturation in hepatocellular carcinoma to suppress cell proliferation and migration.

TLR8-AS1 has been characterized as an oncogenic lncRNA in ovarian cancer, while its role in hepatocellular carcinoma (HCC) is unknown. This study aimed to explore the role of TLR8-AS1 in HCC. TLR8-AS1 expression in HCC and paired non-tumor tissues from 62 HCC patients was determined by RT-qPCR.

Regional cerebral perfusion in patients with amnestic mild cognitive impairment: effect of cerebral small vessel disease.

Objective: To explore the effort of cerebral small vessel disease (CSVD) on regional cerebral perfusion in patients with mild cognitive impairment (MCI) using NeuroGam™ software and evaluate the capability of brain perfusion single photon emission computed tomography (SPECT) in distinguishing MCI with and without CSVD.

Methods: 34 amnestic MCI subjects entered this study, conducting neuropsychological tests, MRI and Technetium ethyl cystine dimer brain perfusion SPECT imaging. All subjects were divided into those with CSVD and those without CSVD.

Stability study of the As(V)-Fe(III) oxyhydroxide coprecipitate over a broad pH range: Characteristics and mechanism.

Fe(III)-oxyhydroxide composites are efficient adsorption materials, however, their detailed geometrical structures and adsorption mechanisms in a broad pH range are still unclear. In this study, the structures of arsenic(V) adsorbed on Fe(III)-oxyhydroxide adsorption complexes were investigated using hybrid density functional theory calculations together with experimental Fourier transform infrared (FT-IR) spectroscopy. Adsorption experiments showed higher arsenic(V) removal rates in the range of pH 5.

Different concentrations of C5a affect human dental pulp mesenchymal stem cells differentiation.

Background: During the process of deep decay, when decay approaches the pulp, an immune response is triggered inside the pulp, which activates the complement cascade. The effect of complement component 5a (C5a) on the differentiation of dental pulp mesenchymal stem cells (DPSCs) is related to dentin reparation. The aim of the present study was to stimulate DPSCs with different concentrations of C5a and evaluate the differentiation of odontoblasts using dentin sialoprotein (DSP).

RNA mA Modification in Cancers: Molecular Mechanisms and Potential Clinical Applications.

N-Methyladenosine (mA) RNA modification brings a new dawn for RNA modification researches in recent years. This posttranscriptional RNA modification is dynamic and reversible, and is regulated by methylases ("writers"), demethylases ("erasers"), and proteins that preferentially recognize mA modifications ("readers"). The change of RNA mA modification regulates RNA metabolism in eucaryon, including translation, splicing, exporting, decay, and processing.

Sensitive osteosarcoma diagnosis through five-base telomerase product-triggered CRISPR-Cas12a enhanced rolling circle amplification.

Osteosarcoma is the most frequent primary malignant bone tumor, composed of mesenchymal cells producing osteoid and immature bone. The sensitive detection of telomerase plays a pivotal role in the early diagnosis and therapeutic treatment of osteosarcoma. We report here an strategy for sensitive telomerase activity detection through the integration of rolling circle amplification (RCA) and a clustered regularly spaced short palindrome repeats (CRISPR)-Cas12a system.

Hydrogen-Bonded Conjugated Materials and Their Application in Organic Field-Effect Transistors.

Recent research on organic semiconductors has revealed that the composition of the constituent organic material, as well as the subtle changes in its structure (the stacking order of molecules), can noticeably affect its bulk properties. One of the reasons for this is that the charge transport in conjugated materials is strongly affected by their structure. Further, the charge mobility increases significantly when the conjugated materials exhibit self-assembly, resulting in the formation of ordered structures.

Dysfunction of peripheral regulatory T cells predicts lung injury after cardiopulmonary bypass.

Lung injury caused by cardiopulmonary bypass (CPB) increases the mortality after cardiac surgery. Previous studies have shown that regulatory T cells (Tregs) play a protective role during CPB, but the correlation between Tregs and CPB-induced lung injury remains unclear. Here, we conducted a prospective study about Treg cells in patient receiving CPB.

Broadcasting of tiny granules by drone to mimic liquid spraying for the control of fall armyworm (Spodoptera frugiperda).

Background: The fall armyworm (FAW), Spodoptera frugiperda (J. E. Smith), is an invasive pest.

RUNX1 can mediate the glucose and O-GlcNAc-driven proliferation and migration of human retinal microvascular endothelial cells.

Introduction: This study aims to determine whether high glucose condition and dynamic O-linked N-acetylglucosamine (O-GlcNAc) modification can promote the proliferation and migration of human retinal microvascular endothelial cells (HRMECs) and whether Runt-related transcription factor 1 (RUNX1) could mediate the glucose and O-GlcNAc-driven proliferation and migration of HRMECs.

Research Design And Methods: Western blot analysis was used to detect the O-GlcNAc modification level and RUNX1 level in cells and retina tissues, cell growth was studied by cell counting kit-8 assay, cell proliferation was detected by immunofluorescence staining. Then, cell migration and tube formation were investigated by scratch-wound assay, Transwell assay, and tube-forming assay.

GGC Repeat Expansion in the Gene Is Associated With a Phenotype of Predominant Motor-Sensory and Autonomic Neuropathy.

There is still a considerable proportion of patients with inherited peripheral neuropathy (IPN) whose pathogenic genes are unknown. This study was intended to investigate whether the GGC repeat expansion in the is presented in some patients with IPN. A total of 142 unrelated mainland Chinese patients with highly suspected diagnosis of IPN without any known causative gene were recruited.

A weak shear stress microfluidic device based on Viscoelastic Stagnant Region (VSR) for biosensitive particle capture.

Particle manipulation in microfluidic devices is of great significance in biological research. However, currently available inertial capture methods require relatively high flow rates, which will cause damage to biological particles, especially for single-celled organisms that are sensitive to environments. Herein, we demonstrate a label-free, size-based, low shear stress manipulation method using the Viscoelastic Stagnant Region (VSR) to capture sensitive bioparticles.

A Synchronous Prediction Model Based on Multi-Channel CNN with Moving Window for Coal and Electricity Consumption in Cement Calcination Process.

The precision and reliability of the synchronous prediction of multi energy consumption indicators such as electricity and coal consumption are important for the production optimization of industrial processes (e.g., in the cement industry) due to the deficiency of the coupling relationship of the two indicators while forecasting separately.

Semi-supervised random forest regression model based on co-training and grouping with information entropy for evaluation of depression symptoms severity.

Semi-supervised learning has always been a hot topic in machine learning. It uses a large number of unlabeled data to improve the performance of the model. This paper combines the co-training strategy and random forest to propose a novel semi-supervised regression algorithm: semi-supervised random forest regression model based on co-training and grouping with information entropy (E-CoGRF), and applies it to the evaluation of depression symptoms severity.

Multi-joint Charcot arthropathy caused by cervical spondylotic myelopathy and adult degenerative scoliosis with syringomyelia: a case report.

Background: Charcot arthropathy, also known as neuropathic arthropathy, is a rare disease whose early diagnosis and treatment are very difficult. Generally, diabetes is considered the most common cause of Charcot arthropathy. Although Charcot arthropathy of other secondary etiology has been reported, in most cases only a single joint is accumulated, and rarely involving the feet and shoulders.

Risk Factors of Psychological Responses of Chinese University Students During the COVID-19 Outbreak: Cross-sectional Web-Based Survey Study.

Background: COVID-19 is a highly contagious and highly pathogenic disease caused by a novel coronavirus, SARS-CoV-2, and it has become a pandemic. As a vulnerable population, university students are at high risk during the epidemic, as they have high mobility and often overlook the severity of the disease because they receive incomplete information about the epidemic. In addition to the risk of death from infection, the epidemic has placed substantial psychological pressure on the public.

A quinone electrode with reversible phase conversion for long-life rechargeable aqueous aluminum-metal batteries.

The exploration of high-performance cathode candidates is of great significance for aqueous aluminum-metal batteries (AAMBs). Here, we, for the first time, report tetrachloro-1,4-benzoquinone (TCQ) as a superior organic AAMB cathode. Owing to its high reversible conversion between the carbonyl and hydroxyl groups, the TCQ cathode delivers a remarkable electrochemical performance.