Publications by authors named "Xin Ran Liu"

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  • Cells react to DNA damage through responses like DNA repair or programmed cell death (apoptosis), but the factors influencing these choices are not well understood.
  • The protein ANGPTL8, which is usually involved in lipid metabolism, also plays a key role in guiding cells towards apoptosis instead of repair when faced with DNA damage.
  • ANGPTL8 interacts with a protein called PARP1, promoting apoptosis by enhancing PARP1's accumulation on damaged DNA, while its own levels decrease after DNA damage to prevent excessive toxicity.
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  • * A new large-scale synthetic method for M[BH] (M = Na, K) was developed, achieving yields up to 88% through a reaction with diglyme at high temperatures, while avoiding toxic substances.
  • * The starting material can be reused multiple times, making the process more economical and supporting future applications in solid-state batteries.
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  • Researchers aim to expand the use of carboranes, which have shown better stability in certain metal-carbon interactions compared to traditional alkyl or aryl groups.
  • Experimental and theoretical studies revealed a unique M⋯C-H interaction where a carbon atom from an arene contributes electrons to a metal, distinguishing it from other types of metal-carbon bonding.
  • The findings highlight the special electronic properties of carboranes and suggest that the M⋯C-H interaction can transform into a more stable C-H bond under specific conditions, opening up new possibilities in organometallic chemistry.
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Soil (or plant) water deficit accelerates plant reproduction. However, the underpinning molecular mechanisms remain unknown. By modulating cell division/number, ABSCISIC ACID-INSENSITIVE 5 (ABI5), a key bZIP (basic (region) leucine zippers) transcription factor, regulates both seed development and abiotic stress responses.

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Exposure of dark-grown etiolated seedlings to light triggers the transition from skotomorphogenesis/etiolation to photomorphogenesis/de-etiolation. In the life cycle of plants, de-etiolation is essential for seedling development and plant survival. The mobilization of soluble sugars (glucose [Glc], sucrose, and fructose) derived from stored carbohydrates and lipids to target organs, including cotyledons, hypocotyls, and radicles, underpins de-etiolation.

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  • * Challenges in carborane development, such as activating B-H bonds, can be addressed through careful selection of metal centers and ligands.
  • * Although research in this area is still emerging, recent findings on weak interactions in carboranes suggest potential advancements in supramolecular applications, particularly for alkane separation.
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Arbuscular mycorrhizal (AM) fungi enhance plant stress tolerance, but it is unclear whether AM fungi affect heat tolerance in cucumbers. This study aimed to analyze how an AM fungus, , affected growth, chlorophyll, five osmolytes, and plasma membrane intrinsic proteins () and heat shock protein 70 () gene expression in cucumber leaves after a short-term (80 h) heat stress. Heat treatment significantly reduced root AM fungal colonization rate (0.

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Ethnopharmacological Relevance: Epimedium koreanum Nakai (E. koreanum), a member of the genus Epimedium in the family Berberidaceae, is a well-known and well-liked traditional herb used as a "kidney tonic". For thousands of years, it has been utilized for renal yang deficiency, impotence, spermatorrhea, impotence, weakness of tendons and bones, rheumatic paralysis and discomfort, numbness, and constriction.

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The study was aimed at investigating the effects of walnut oligopeptides (WOPs) on alcohol-induced acute liver injury and its underlying mechanisms. Male Sprague Dawley (SD) rats were randomly assigned to six groups: normal control, alcohol control, whey protein (440 mg/kg.bw), and three WOPs (220 mg/kg.

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The aim of this study was to clarify the anti-fatigue effect of peanut oligopeptides (POPs) in mice and to investigate its possible underlying mechanism. A total of 150 male ICR mice were randomly assigned into five groups: control, whey protein (0.50 g/kg·bw), and three peanut peptide groups (0.

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  • Developing new methods for assembling supramolecular compounds has been a challenging area of research.
  • This study combines B-C coupling reactions with a process called "cage walking" to create supramolecular cages using dipyridine linkers.
  • By varying the length of the linkers, researchers can control the size and type of structures formed, which could lead to innovative applications in supramolecular chemistry.
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  • The study aimed to assess sTNF-RI as a potential biomarker for kidney involvement in patients with systemic lupus erythematosus (SLE), focusing on those with lupus nephritis and those without renal issues.
  • Results showed significantly higher levels of plasma sTNF-RI in patients with lupus nephritis compared to those without kidney issues and healthy controls, indicating a strong link to disease activity and renal function.
  • The findings suggest that sTNF-RI could serve as an independent risk factor for renal involvement, leading to the development of a practical nomogram for predicting disease activity in SLE patients based on specific risk factors.
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  • Researchers developed rectangular carborane-based metallacycles that can effectively separate -pentane from mixtures with -pentane and -pentane, addressing challenges in distinguishing alkanes with similar structures.
  • The metallacycles achieve a high purity level of 97% in the separation process, thanks to their ability to selectively interact with -pentane through size matching and specific chemical interactions.
  • The carborane-based metallacycles can be recycled for repeated use after separation, and their design allows for potential applications in various separation challenges across different chemical compounds.
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  • Systemic lupus erythematosus (SLE) is an autoimmune disease linked to the production of autoantibodies, and the role of long non-coding RNAs (lncRNAs) in its development is still not fully understood.
  • * The study utilized genetic association analysis from existing genome-wide association studies (GWAS) and validated findings with an independent cohort, identifying 33 single nucleotide polymorphisms (SNPs) associated with SLE susceptibility.
  • * The most significant SNP, rs844649, showed a strong correlation with SLE and increased mRNA and protein expression levels in blood samples from patients, suggesting that lncRNA coding genes play a crucial role in the disease's susceptibility.*
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Objective: The purpose of this study is to evaluate the association between left iliac vein (LIV) compression and inferior vena cava thrombosis (IVCT) in patients with LIV involvement of deep vein thrombosis (DVT).

Methods: A total of 263 consecutive patients with DVT were reviewed retrospectively and divided into a group with IVCT and a group without IVCT. The influences of LIV smallest diameter and percentage compression on the risk of IVCT were investigated using logistic regression analysis.

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Hepatic ischemia-reperfusion injury (HIRI) is a major clinical cause of morbidity and mortality in liver surgery and transplantation. Many studies have found that nitric oxide (NO) plays an important role in the HIRI and its increase or decrease can affect the progression and outcome of HIRI. However, the role of NO in HIRI is controversial and complicated.

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  • Separation of light hydrocarbons, like cyclohexane, is crucial for various industries, and boron clusters offer unique structures that can enhance this process.
  • Researchers designed a special metallacage that uses specific ligands to efficiently capture cyclohexane from a mixture with benzene, achieving a high purity of 98.5%.
  • The selective trapping of cyclohexane and cyclohexene in the metallacage is due to various weak interactions and suggests potential future applications in advanced chemistry for separating hydrocarbons.
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Objectives: IgA Nephropathy (IgAN) is common chronic kidney disease with a high incidence. This study aims to analyze comprehensively therapeutic clinical trials for IgAN registered on ClinicalTrials.gov.

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  • Dysregulation of T cells is central to systemic lupus erythematosus (SLE), and recent studies identified genetic variants in the CTLA4-ICOS region that contribute to SLE risk.
  • A significant variant, rs17268364, was found to increase susceptibility to SLE in Chinese populations and is associated with lower CTLA4 expression specifically.
  • The risk allele of rs17268364 correlates with higher levels of key interferon-related molecules in healthy individuals, indicating a potential mechanism for SLE development.
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A safe and efficient synthetic method for MBH (M = Na, K, Rb and Cs) has been developed with excellent yields by directly reacting the corresponding MBH with the dimethyl sulfide borane complex (DMS·BH). A general mechanism for constructing BH, a basic unit for building polyhedral boranes, has been unravelled.

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A recent genome-wide association study (GWAS) of Asian ancestry reported that single nucleotide polymorphism (SNP) in (telomerase reverse transcriptase) was associated with systemic lupus erythematosus (SLE). TERT has a critical role in maintaining the chromosomal stability and the length of telomere. Given that only a small portion of the genetic heritability of SLE has been explained so far, we aimed to identify novel loci in telomere-related genes responsible for SLE susceptibility in Chinese populations.

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This study investigated the antioxidant effects of whey protein peptide on learning and memory in aging C57BL/6N mice. A total of 72 SPF male C57BL/6N mice were used. Twelve mice were randomly selected as the control group, and the other mice were intraperitoneally injected with D-galactose (100 mg/kg body weight for 6 weeks), during which, the mice in the control group were intraperitoneally injected with the same amount of normal saline.

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Radiation therapy is widely used in the treatment of tumor diseases, but it can also cause serious damage to the body, so it is necessary to find effective nutritional supplements. The main purpose of this study is to evaluate the protective effect of whey hydrolysate peptides (WHPs) against Coγ radiation damage in mice and explore the mechanism. BALB/c mice were given WHPs by oral gavage administration for 14 days.

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The controllable B-H bond activation of carboranes has long been a compelling challenge. However, as the symmetry of -carborane places the same charge on all of its ten boron atoms, controlling the regiochemistry of B-H bond activation in these molecules has remained out of reach ever since their discovery. Herein, we describe how to use steric effects to achieve a regioselective process for B-H activation of -carborane.

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