[Mean transit time of water bodies in a typical soil-plant-atmosphere continuum of the subtropical monsoon region].

The mean transit time (MTT) is a good indicator of water cycle processes. We know little about the MTT of different water bodies within the soil-plant-atmosphere continuum (SPAC) in the subtropical monsoon region. We estimated the MTT of stratified soil water at different depths as well as the xylem water and leaf water in typical woodland located in Changsha City from March 2017 to October 2019.

[Value of complement component 3 in predicting the prognosis of children with sepsis].

Objectives: To investigate changes in complement component 3 (C3) levels in children with sepsis and its correlation with the severity of sepsis and to explore the significance of C3 in predicting mortality in children with sepsis.

Methods: A retrospective analysis was conducted on 529 children with sepsis who were admitted to the Pediatric Intensive Care Unit in Hunan Children's Hospital between November 2019 and September 2021. The children were categorized into two groups based on their prognosis at day 28 after sepsis diagnosis: the survival group (=471) and the death group (=58).

[Clinical application of plasma exchange combined with continuous veno-venous hemofiltration dialysis in children with refractory Kawasaki disease shock syndrome].

Objectives: To study the role of plasma exchange combined with continuous blood purification in the treatment of refractory Kawasaki disease shock syndrome (KDSS).

Methods: A total of 35 children with KDSS who were hospitalized in the Department of Pediatric Intensive Care Unit, Hunan Children's Hospital, from January 2019 to August 2022 were included as subjects. According to whether plasma exchange combined with continuous veno-venous hemofiltration dialysis was performed, they were divided into a purification group with 12 patients and a conventional group with 23 patients.

Impact of Multidisciplinary Collaborative Intervention on Isolation Implementation in Prevention and Control of Multi-drug Resistance Infection.

Objective: Contact precautions, especially the initiation of isolation, are important measures to prevent and control multidrug-resistant organisms (MDROs). However, the implementation in clinical practice remains weak. This study aimed to analyze the impact of multidisciplinary collaborative intervention on isolation implementation in multidrug-resistant infection, and determine the factors that affect the implementation of isolation measures.

[Risk factors for early acute kidney injury after cardiac arrest in children in the pediatric intensive care unit and a prognostic analysis].

Objectives: To investigate the risk factors for acute kidney injury (AKI) in children with cardiac arrest (CA) and the influencing factors for prognosis.

Methods: A retrospective analysis was performed on the medical records of the children who developed CA in the pediatric intensive care unit (PICU) of Hunan Children's Hospital from June 2016 to June 2021. According to the presence or absence of AKI within 48 hours after return of spontaneous circulation (ROSC) for CA, the children were divided into two groups: AKI (=50) and non-AKI (=113).

[Therapeutic plasma exchange in the pediatric intensive care unit: a single-center retrospective study].

Objectives: To study the indication for therapeutic plasma exchange (TPE) and related complications in children admitted to the pediatric intensive care unit.

Methods: A retrospective analysis was performed on the medical records of the children who received TPE in the Pediatric Intensive Care Unit, Hunan Children's Hospital, from March 2015 to March 2021. The indication for TPE and related complications were analyzed and compared with the American Society for Apheresis (ASFA) indication categories.

Efficacy of plasma exchange in children with severe hemophagocytic syndrome: a prospective randomized controlled trial.

Objectives: To investigate the efficacy and application value of plasma exchange as an adjuvant therapy in children with hemophagocytic syndrome (HPS).

Methods: A prospective randomized controlled trial was designed. Forty children with severe HPS were enrolled, who were treated in the pediatric intensive care unit (PICU) of Hunan Children's Hospital from October 2018 to October 2020.

Effects of pore size and porosity on cytocompatibility and osteogenic differentiation of porous titanium.

To find out the optimal porosity and pore size of porous titanium (Ti) regarding the cytocompatibility and osteogenic differentiation. Six groups of porous Ti samples with different porosities and pore sizes were fabricated by the powder metallurgy process. The microstructure and compressive mechanical properties were characterized.

[Application of double plasma molecular adsorption system in children with acute liver failure].

Objective: To study the efficacy and safety of double plasma molecular absorption system (DPMAS) in the treatment of pediatric acute liver failure (PALF).

Methods: A prospective analysis was performed on the medical data of children with PALF who were hospitalized in the Intensive Care Unit (ICU), Hunan Children's Hospital, from March 2018 to June 2020. The children were randomly divided into two groups:plasma exchange group (PE group) and DPMAS group (=18 each).

[Clinical application of blood purification in treatment of severe adenovirus pneumonia].

Objective: To study the role of blood purification in the treatment of severe adenovirus pneumonia.

Methods: A total of 57 children with severe adenovirus pneumonia who underwent mechanical ventilation from February to June, 2019, were enrolled. According to whether blood purification was performed, they were divided into a purification group with 22 children and a conventional group with 35 children.

Quality Management Model for Phase I Clinical Drug Trials: A Structural Equation Model.

This study aimed to construct a quality management model for phase I clinical drug trials. A cross-sectional survey was conducted and data were collected from 604 respondents at 69 institutions in China engaged in phase I clinical drug trials. Exploratory and confirmatory factor analyses were used to develop the survey tool.

[Clinical features of severe type 7 adenovirus pneumonia: an analysis of 45 cases].

Objective: To study the clinical features of severe type 7 adenovirus pneumonia in children.

Methods: A retrospective analysis was performed for the clinical data of children who were diagnosed with severe type 7 adenovirus pneumonia from February to June, 2019.

Results: Among the 45 children, the male/female ratio was 3:2 and the median age was 14 months.

Developmental Population Pharmacokinetics and Dosing Optimization of Cefepime in Neonates and Young Infants.

Objective: Cefepime is used to treat severe infections in neonates. Pharmacokinetic data have only been evaluated among preterm neonates and population pharmacokinetic model lacked external validation. Hence, our aim is to obtain the population pharmacokinetic parameters of cefepime with large sampling and optimize the cefepime dosage regimen for neonatal infection based on developmental pharmacokinetics-pharmacodynamics.

A meta-analysis of treatment effects of imiquimod for basal cell carcinoma.

Objective: We conducted this meta-analysis to assess the efficacy and safety of imiquimod in comparison with other treatments in patients with BCC.

Methods: A comprehensive literature search was performed in the database of PubMed, Embase, and Web of Science. Outcomes of interest included histological/composite clearance rate, success rate, complete response rate, tumor free survival, and adverse events.

Effect of Personalized Music Intervention in Mechanically Ventilated Children in the PICU: A Pilot Study.

Objectives: To determine the feasibility of a personalized music intervention with mechanically ventilated patients in the PICU.

Design: Pilot study with a quasi-experimental design.

Setting: Tertiary children's hospital in China with a 40-bed PICU.

[Application of dexmedetomidine in children with agitation during ventilator weaning].

Objective: To study the clinical effect and safety of dexmedetomidine in children with agitation during ventilator weaning.

Methods: A prospective open observational study was performed for children who were admitted to the intensive care unit and experienced mechanical ventilation between March 2017 and August 2018. They were given dexmedetomidine due to the failure in the spontaneous breathing test (SBT) caused by agitation.

Model of Healthcare-Associated Infection Control in Primary Health Care Institutions: A Structural Equation Modeling.

The purpose of this study was to construct the model of organization system, management, training and surveillance in healthcare-associated infection prevention and control (IC) of primary health care institutions and identify its effect on patient safety and decreasing economic burden by standardizing IC. A cross-sectional survey was conducted with questionnaires. Data were collected from 268 primary health care institutions in Hubei province, China.

Effects of acid-alkali treatment on bioactivity and osteoinduction of porous titanium: An in vitro study.

Background: To elucidate the bioactivity and bone regeneration of porous titanium surfaces treated using acid-alkali combination, and to define the optimal alkali reaction time.

Methods: Ten groups of porous Ti with at least 3 per group undergoing different acid-alkali treated time were prepared. The surface was characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), bicinchoninic acid method (BCA), optical contact angle measurement and Raman spectrometry.

Does hospital ownership influence hand hygiene compliance?

The issue as to whether hospital ownership has an impact on the quality of care has long been a serious concern. Hand hygiene (HH) compliance is regarded as an important indicator of the quality of care in the control of hospital-acquired infections. However, little information is available on whether hospital ownership influences HH compliance.

Three-dimensional characterization and distribution of fabrication defects in bilayered lithium disilicate glass-ceramic molar crowns.

Objective: To investigate and characterize the distribution of fabrication defects in bilayered lithium disilicate glass-ceramic (LDG) crowns using micro-CT and 3D reconstruction.

Methods: Ten standardized molar crowns (IPS e.max Press; Ivoclar Vivadent) were fabricated by heat-pressing on a core and subsequent manual veneering.

Maintenance of totally implantable ports in Zhongshan Hospital: a best practice implementation project.

Background: The totally implantable port is a common central venous access device. The cost of implantation and maintenance however is very expensive. At present, the biggest problem regarding the promotion and the use of implantable ports in China is lack of well trained professional healthcare providers.