Characterization of quinazolinone calcilytic therapy for autosomal dominant hypocalcemia type 1 (ADH1).

Germline gain-of-function mutations of the calcium-sensing receptor (CaSR) result in autosomal dominant hypocalcemia type 1 (ADH1), which may cause symptomatic hypocalcemia with low parathyroid hormone (PTH) concentrations. Negative allosteric CaSR modulators, known as calcilytics, have potential as a targeted ADH1 therapy and consist of two main classes, which are the amino alcohols and the quinazolinones. Amino alcohol calcilytics have been extensively assessed as ADH1 therapies, but may not be effective for all ADH1-causing mutations.

Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate oxidative stress in Alzheimer's disease in vitro and in vivo models by regulating Mst1 and affecting the Nrf2/Sirt3 pathway.

Alzheimer's disease (AD) is a common neurodegenerative disorder, and oxidative stress plays a significant role in its progression. Owing to its nourishing effects, Eleutherococcus senticosus (Rupr. & maxim.

Reply to Okura et al. Comment on "Pu et al. Predicting Postoperative Lung Cancer Recurrence and Survival Using Cox Proportional Hazards Regression and Machine Learning. 2025, , 33".

Thank you for your thoughtful and constructive comments on our study [...

Simultaneous quantification of four urinary biomarkers related to oxidative stress using UHPLC-QqQ-MS/MS.

Oxidative stress biomarkers have been associated with both acute and chronic health outcomes. However, traditional methods analyze different biomarkers separately, resulting in complex sample preparation, high sample consumption, lengthy processing time, and limited comparability. In this study, we presented a newly developed and validated method for the simultaneous determination of oxidative stress from multiple perspectives (DNA, lipids, and antioxidants).

Tuning the electronic state of CoFe alloy via in-situ partial Co nitridation for enhanced oxygen electrocatalysis in zinc-air battery.

The low catalytic activity and high susceptibility to corrosion of CoFe alloys limit their efficiency and stability in oxygen evolution and reduction reactions (OER/ORR). Here, via a partial nitridation strategy, CoN is in-situ formed adjacent to CoFe alloy to construct a well-defined heterointerface within N-doped bamboo-like carbon nanotube (CoN-CoFe/NCNT). As indicated by computational calculations, the interfacial electrons are transferred from Fe atom to CoN in the CoN-CoFe heterojunction, optimizing the adsorption of O-intermediates and accelerating the rate-determining steps (*O to *OH in ORR and *O to *OOH in OER).

Prevalence and risk factors of self-reported adverse drug events in elderly co-morbid patients in northeastern China: a cross-sectional study.

Background: Older adults are vulnerable to adverse drug events given the pharmacokinetic and pharmacodynamic changes that coming with ageing, as well as they often take multiple medications for their chronic health conditions, especially older co-morbidities. ADEs can cause unnecessary emergency department visits and hospitalization, which contribute to financial burden and decreased quality of life. This study aims to investigate the prevalence of adverse drug events in elderly co-morbid patients in Liaoning province and explore its risk factors, in order to ensure medication safety in elderly patients.

Association of Plaque Characteristics With New Ischemic Lesions After Carotid Artery Stenting.

Background: Carotid artery stenting (CAS) is a common treatment for carotid artery stenosis, but it can lead to new ischemic brain lesions on diffusion-weighted images (DWI) during the perioperative period. Identifying these lesions early is crucial to preventing recurrent ischemic strokes.

Methods: This retrospective study included 47 patients who underwent CAS.

Enhanced stimulated Brillouin scattering in valley Hall photonic-phononic topological waveguides.

Stimulated Brillouin scattering (SBS) provides a robust and versatile foundation for the development of mode-locked lasers, microwave signal generators, and optical gyroscopes across diverse optical platforms. Nonetheless, the relatively low efficacy of Brillouin interactions in traditional silicon photonic waveguides presents a barrier to the advances of silicon-based Brillouin laser technology. The emergence of hybrid photonic-phononic waveguides has brought to light the robust and adaptable nature of Brillouin interactions in silicon, marking a significant advancement.

Cell Free DNA-Based Prediction of Prognosis for Patients on Veno-Arterial Extracorporeal Membrane Oxygenation.

Introduction: Elevated cell-free DNA (cfDNA) was observed in patients receiving venoarterial (VA) extracorporeal membrane oxygenation (ECMO), but the clinical relevance of cfDNA is still not clear. We aimed to establish an predictive model based on the cfDNA to predict the prognosis for patients on ECMO, and reveal the values of cfDNA for complications of limb ischemia and bleeding/thromboembolic events.

Methods: Single-center, retrospective evaluation of patients with ECMO support from 2018 through 2023.

Geometric Self-Supervised Learning: A Novel AI Approach Towards Quantitative and Explainable Diabetic Retinopathy Detection.

Background: Diabetic retinopathy (DR) is the leading cause of blindness among working-age adults. Early detection is crucial to reducing DR-related vision loss risk but is fraught with challenges. Manual detection is labor-intensive and often misses tiny DR lesions, necessitating automated detection.

Development of asparagine endopeptidase inhibitors for treating neurodegenerative diseases.

Asparagine endopeptidase (AEP), or legumain, is a cysteine protease implicated in various disorders, including atherosclerosis, cancers, neurodegenerative diseases, and inflammation. The development of AEP inhibitors has emerged as a promising therapeutic strategy to modulate AEP activity and slow disease progression. Various AEP inhibitors have been explored, encompassing small molecules, peptide-based, antibody-based, and natural inhibitors.

Structure Evolution of Organic Luminescent Molecules Utilizing Through-Space Charge Transfer Mechanism.

Organic structures provide an extensive platform for luminescent materials thanks to the easy to design and synthesize, low toxicity and tunable functionalization. Through-space charge transfer (TSCT) in organic molecules, characterized by the transfer of excitons through spatial charge motion, has emerged as a significant research topic in optoelectronics, offering new avenues for the development of high-performance luminescent materials. This review systematically summarizes the fundamental principles of TSCT and highlights the recent advancements in organic small molecules that exhibit this emission mechanism.

Evaluating the Impact of Omega-3 Fatty Acids and Genetic Susceptibility on Atopic Dermatitis in Adults.

Fatty acids (FAs) involvement in atopic dermatitis (AD) prevention is inconclusive, and the modification effect by genetic risk profiles remains unknown. The aim of this study is to explore the association between circulating FAs, genetic risk factors, and AD in adults. Utilizing the UK Biobank dataset, we evaluated the impacts of FAs on the risk of elderly-onset AD and explored the combined effects of FA levels and genetic susceptibility.

Experimental Study on Spectral Characteristic Regulation of Noble Metal Nanofluids.

In the splitting photovoltaic/thermal hybrid system, splitting nanofluids with dynamic optical regulation abilities enables flexible thermal/electrical output. In the present work, the optical regulation ability of precious metal Ag nanofluids was investigated experimentally. Three types of nanoparticles, including Ag, Ag coated with SiO(Ag@SiO), and ITO nanoparticles were prepared.

Clinical Outcomes of DAMIS Traction Table-Assisted Anterior Approach versus Posterolateral Approach on Total Hip Arthroplasty in the Treatment of Femoral Head Necrosis.

Aim: Femoral head necrosis often leads to hip joint dysfunction, which can be effectively treated with total hip arthroplasty (THA). This study compares the clinical outcomes of direct anterior minimally invasive surgery (DAMIS) traction table-assisted anterior approach and the traditional posterolateral approach (PLA) on THA for femoral head necrosis.

Methods: A total of 150 patients with femoral head necrosis, admitted between September 2019 and May 2022, were included in this study.

Effect of dietary anthocyanins on the risk factors related to metabolic syndrome: A systematic review and meta-analysis.

Objective: This meta-analysis aims to systematically investigate whether dietary anthocyanin supplementation can reduce metabolic syndrome (MetS)-related risk factors: abdominal obesity, dyslipidemia (low high-density lipoprotein cholesterol (HDL-C) and hypertriglyceridemia), hypertension, and hyperglycemia by conducting a meta-analysis of randomized controlled trials (RCTs).

Methods: A systematic search of 5 electronic databases (PubMed, Web of Science, Scopus, Cochrane Library, and Embase) was conducted from inception until April 25, 2024. A total of 1213 studies were identified, of which randomized controlled trials involving subjects with MetS-related factors, comparing dietary anthocyanin supplementation with placebo, and reporting results on anthropometric, physiological, and metabolic markers relevant to this study were selected.

Study on methane flux variation characteristics and regulation mechanisms in urban wetlands under different restoration years and moisture gradients.

Urban wetlands play a crucial role in the regional carbon balance and regulation of greenhouse gas (GHG) emissions; however, the effects of restoration year and moisture gradient on methane (CH) fluxes during wetland restoration and their driving mechanisms are unclear. This study investigated CH fluxes, environmental factors, and methanogenic communities in urban wetlands under different restoration years (2 years, 9 years, and natural wetland without restoration) and moisture gradients (perennial waterlogging, seasonal waterlogging, and no surface waterlogging) to reveal the spatial and temporal variation characteristics of CH fluxes in urban wetlands and their regulatory mechanisms. The results indicated that wetlands with short-term restoration (2 years) exhibited significantly higher CH fluxes under conditions of sufficient moisture (such as perennial waterlogging), whereas wetlands with long-term restoration (9 years) exhibited lower CH fluxes.

Associations between domestic hard water exposure and incident psoriasis in adults: Insights from the UK Biobank cohort study.

Although exposure to hard water is associated with various inflammatory skin conditions, the specific relationship between hard water and psoriasis has not been clearly defined. We analyzed data from 486,414 participants in the UK Biobank cohort to explore the association between domestic hard water exposure and the incidence of psoriasis. Domestic water hardness, measured in calcium carbonate concentration, was obtained in 2005 from local water providers in Wales, Scotland, and England.

Downregulated TFPI2 accelerates skin aging by repressing cell cycle via PI3K/Akt/CDC6 pathway.

Tissue factor pathway inhibitor 2 (TFPI2) is known to regulate the proliferation of various cell types and tumor tissues; however, its role in the process of skin aging has not been elucidated. In this study, we identify TFPI2 as a potential antagonist of aging. Our findings indicate that TFPI2 expression is downregulated in aging skin tissues and senescent human dermal fibroblasts (HDFs), and that the depletion of TFPI2 accelerates the senescence of HDFs and the aging of skin.

Associations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness.

Background: Epidemiological studies reported associations between ozone (O) exposure and cardiovascular diseases, yet the biological mechanisms remain underexplored. Hypoxia is a shared pathogenesis of O-associated diseases; therefore, we hypothesized that O exposure may induce changes in hypoxia-related markers, leading to adverse cardiovascular effects.

Objectives: This study aimed to investigate associations of short-term O exposure with hypoxic biomarkers and arterial stiffness.

Identification of the SP gene family and transcription factor SlSP5G promotes the high-temperature tolerance of tomatoes.

Some members of the SELF PRUNING (SP) gene family have been shown to play critical roles in developmental processes and stress responses across a wide range of plant species. The study identifies 13 members that can be divided into three subfamilies based on evolutionary analysis. Cis-Acting element analysis of the promoter regions indicated the presence of numerous stress- and hormone-responsive elements in the SlSP family.

Genome-wide analyses of the NAC transcription factor gene family in provide valuable insights into the natural process of leaf senescence.

is a deciduous shrub or small tree. It is a popular ornamental plant because of its beautiful leaves, which change colour in autumn. This study revealed 116 genes within the genome of .

Thermosensitive-based synergistic antibacterial effects of novel LL37@ZPF-2 loaded poloxamer hydrogel for infected skin wound healing.

Trauma healing is the process of healing after the body has been subjected to an external force and the skin and other tissues have become dissected or defective, showing the synergistic effect of various processes. Therefore, the investigation of innovative wound dressings has significant research and clinical implications. In this study, we constructed a zinc based metal-organic framework (MOF) and loaded with antimicrobial peptide LL37 to prepare LL37@ZPF-2 (ZPF = zeolite pyrimidine backbone), which was subsequently integrated with Poloxamer 407 to fabricate LL37@ZPF-2 thermosensitive hydrogel.