Creep model of bond-degradation in deep granite based on variable radius particle clump.

The creep failure of rocks is related to its microstructure, external loading and time. A nonlinear yield model was introduced to describe the variation in the cohesion and friction angle with plastic strain and intergranular stress. The mechanical properties and creep characteristics of deep granite were obtained by indoor tests, and a variable radius particle clump model was constructed based on the particle flow method.

Detection of zearalenone by electrochemical aptasensor based on enzyme-assisted target recycling and DNAzyme release strategy.

Zearalenone has a high level of detection and exceedance in cereals and by-products. Herein, an electrochemical aptasensor for ZEN detection was proposed. The selected aptamer, which has a high affinity for ZEN, serves as a molecular recognition element and effectively avoids interference from other toxins.

Regional antimicrobial resistance gene flow among the One Health sectors in China.

Background: Antimicrobial resistance poses a significant threat to global health, with its spread intricately linked across human, animal, and environmental sectors. Revealing the antimicrobial resistance gene (ARG) flow among the One Health sectors is essential for better control of antimicrobial resistance.

Results: In this study, we investigated regional ARG transmission among humans, food, and the environment in Dengfeng, Henan Province, China by combining large-scale metagenomic sequencing with culturing of resistant bacterial isolates in 592 samples.

Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro.

The transcription factor p63 is expressed in many different isoforms as a result of differential promoter use and splicing. Some of these isoforms have very specific physiological functions in the development and maintenance of epithelial tissues and surveillance of genetic integrity in oocytes. The ASPP family of proteins is involved in modulating the transcriptional activity of the p53 protein family members, including p63.

RBM47 is a novel immunotherapeutic target and prognostic biomarker in gliomas.

The role of RBM47, an RNA-binding protein, in shaping the immune landscape of gliomas and tumor immune responses is yet to be fully studied. Therefore, a comprehensive investigation into the immunomodulatory roles of RBM47 in gliomas was conducted, leveraging gene expression data from multi-omic datasets. The prognosis of patients with gliomas considering RBM47 was elucidated using bioinformatics methods and clinical data, with results validated using immunohistochemistry and immunofluorescence analyses.

Mechanisms of thermal, acid, desiccation and osmotic tolerance of spp.

spp. exhibit remarkable resilience to extreme environmental stresses, including thermal, acidic, desiccation, and osmotic conditions, posing significant challenges to food safety. Their thermotolerance relies on heat shock proteins (HSPs), thermotolerance genomic islands, enhanced DNA repair mechanisms, and metabolic adjustments, ensuring survival under high-temperature conditions.

[Identification and Analysis of Irregular Antibodies in Hospitalized Patients Prepared to Accept Blood Transfusion].

Objective: To analyze the type and distribution characteristics of irregular antibodies in 71 847 hospitalized patients who prepared to accept blood transfusion, and to explore their role in safe blood transfusion.

Methods: 71 847 patients who applied for red blood transfusion from January 2020 to October 2023 were selected. All specimens were screened and identified for the irregular antibody by microcolumn gel antiglobulin technique.

Self-assembled natural triterpenoids for the delivery of cyclin-dependent kinase 4/6 inhibitors to enhance cancer chemoimmunotherapy.

Immunogenic cell death (ICD) has recently emerged as a promising strategy in reinforcing anti-PD-L1 blockade immunotherapy of triple-negative breast cancer (TNBC). The CDK4/6 inhibitor palbociclib (PAL), as a clinical star medicine targeting the cell cycle machinery, is an ideal candidate for fabricating a highly efficient ICD inducer for TNBC chemoimmunotherapy. However, the frequently observed chemoresistance and clinical adverse effects, as well as significant antagonistic effects when co-administered with certain chemotherapeutics, have seriously restricted the efficiency of PAL and the feasibility of combination strategies.

Iodine-131 radioembolization boosts the immune activation enhanced by icaritin/resiquimod in hepatocellular carcinoma.

Transarterial radioembolization (TARE) is a recommended locoregional strategy for intermediate hepatocellular carcinoma (HCC), whereas, the effect is insufficient to reverse the immunosuppression tumor microenvironment, and the overall benefits for patients remain to be improved. In this study, a multifunctional microsphere (MS) I-ICT/R848-MS is developed to propose an approach combined with TARE, icaritin (ICT) and immune modulator resiquimod (R848). ICT and iodine-131 (I) radiation can induce immunogenic cell death, which, in combination with R848, will boost dendritic cell (DC) maturation.

Characterization and rational engineering of a novel laccase from Geobacillus thermocatenulatus M17 for improved lignin degradation activity.

Lignin, with its complex, high-molecular-weight aromatic polymer structure and stable ether or ester bonds, greatly impedes the efficient degradation of lignocellulosic waste. Bacterial laccases have gained attention for their potential in lignocellulosic waste degradation due to their resilience in extreme conditions and ability to be produced in large quantities. In this study, a novel laccase from Geobacillus thermocatenulatus M17 was identified and expressed in E.

Transarterial Chemoembolization Plus Camrelizumab and Rivoceranib versus Camrelizumab and Rivoceranib Alone for BCLC Stage C Hepatocellular Carcinoma.

Purpose: Camrelizumab and rivoceranib together provide a new first-line treatment approach for unresectable hepatocellular carcinoma (HCC). Meanwhile, transarterial chemoembolization (TACE) is an effective method for the local control of the HCC. The study compared the clinical benefit and safety between TACE with camrelizumab-rivoceranib and camrelizumab-rivoceranib alone for Barcelona Clinic Liver Cancer (BCLC)-C HCC patients.

Tunable Topological Transitions Probed by the Quantum Hall Effect in Twisted Double Bilayer Graphene.

The moiré system provides a tunable platform for investigating exotic quantum phases. Particularly, the displacement field is crucial for tuning the electronic structures and topological properties of twisted double bilayer graphene (TDBG). Here, we present a series of -tunable topological transitions by the evolution of quantum Hall phases (QHPs) in the valence bands of TDBG.

Effects of exopolysaccharides form Lactobacillus plantarum KX041 on high fat diet-induced gut microbiota and inflammatory obesity.

Lactobacillus plantarum KX041 is a probiotics obtained from early screening, which can relieve inflammation and enrich the anti-obesity intestinal flora, and produce high yield of exopolysaccharides (EPS). The extraction, structure and physicochemical properties of EPS have been completed earlier. However, whether the functional activity of L.

Hidden Spread of Rare Serovars Isolated from Healthy Individuals - Yulin City, Guangxi Zhuang Autonomous Region, China, 2013-2022.

What Is Already Known About This Topic?: The emergence of rare multidrug-resistant serovars is increasingly common in developing countries, posing a significant public health risk.

What Is Added By This Report?: This report identified five rare serovars in China for the first time and using whole-genome sequencing, identified their hidden spread among healthy individuals. Additionally, antibiotic resistance genes and virulence genes were identified.

Cardiocutaneous syndrome is caused by aggregation of iASPP mutants.

The ASPP (apoptosis-stimulating protein of p53) family of proteins is involved in many cellular interactions and is starting to emerge as a major scaffolding hub for numerous proteins involved in cancer biology, inflammation and cellular integrity. It consists of the three members ASPP1, ASPP2 and iASPP which are best known for modulating the apoptotic function of p53, thereby directing cell fate decision. Germline mutations in iASPP have been shown to cause cardiocutaneous syndromes, a combination of heart and skin defects usually leading to death before the age of five.

Multiphoton Excited Fluorescence Imaging over Metal-Organic Frameworks.

Multiphoton excited fluorescence (MPEF) imaging has emerged as a powerful tool for visualizing biological processes with high spatial and temporal resolution. Metal-organic frameworks (MOFs), a class of porous materials composed of metal ions or clusters coordinated with organic ligands, have recently gained attention for their unique optical properties and potential applications in MPEF imaging. This review provides a comprehensive overview of the design, synthesis, and applications of multiphoton excited fluorescence imaging using MOFs.

Lysozyme-targeted liposomes for enhanced tubular targeting in the treatment of acute kidney injury.

Acute kidney injury (AKI) is defined by the release of pro-inflammatory factors, leading to structural damage in renal tubules and subsequent tubular cell injury and death. Delivering drugs specifically to renal tubules to mitigate tubular cell damage holds potential for AKI treatment. In this work, we developed functional liposomes (LZM-PLNPs-TP) designed to bypass the glomerular filtration barrier and target tubules by leveraging the unique structural and pathological characteristics of glomeruli and tubules.

The role of nanomaterials in revolutionizing ischemic stroke treatment: Current trends and future prospects.

Ischemic stroke has a high disability rate, which leads to irreversible neuronal death. The efficacy of conventional stroke treatments, including thrombolytic and neuroprotective therapies, is constrained by a number of factors, including safety concerns and inefficient drug delivery. The advent of nanomaterials has created new avenues for stroke therapy, facilitating enhanced pharmacokinetic behavior of drugs, effective drug accumulation at the target site, augmented therapeutic efficacy, and concomitant reduction in side effects.

Carried by a Transferable Plasmid in a Strain Isolated from Healthy Individuals.

Objective: Our study aimed to conduct genomic characterization of strains carrying the gene in the intestinal tract of healthy individuals. The objectives were to underscore the importance of genomic surveillance for drug resistance in both commensal and pathogenic bacteria among healthy populations, and to establish protocols for regulating drug resistance plasmids based on the completion of a comprehensive map of drug resistance plasmid genomes.

Methods: We performed antimicrobial susceptibility testing and employed second- and third-generation sequencing techniques to analyze strains harboring the gene, to surveil drug-resistant bacteria in the intestines of healthy subjects.

Draft genome sequences of two distinct isolates coinfecting a patient.

is a spore-forming anaerobic Gram-positive bacillus. In this study, two distinct strains of causing coinfection were isolated from the same fecal sample. Whole-genome sequencing was performed on these two strains to elucidate their genomic characteristics.

Microscale droplet assembly enables biocompatible multifunctional modular iontronics.

Hydrogel iontronic devices can emulate biological functions and communicate with living matter. But the fabrication of miniature, soft iontronic devices according to modular designs has not been achieved. In this work, we report the use of surfactant-supported assembly of freestanding microscale hydrogel droplets to construct various iontronic modules, circuits, and biointerfaces.

Strong long ties facilitate epidemic containment on mobility networks.

The analysis of connection strengths and distances in the mobility network is pivotal for delineating critical pathways, particularly in the context of epidemic propagation. Local connections that link proximate districts typically exhibit strong weights. However, ties that bridge distant regions with high levels of interaction intensity, termed strong long (SL) ties, warrant increased scrutiny due to their potential to foster satellite epidemic clusters and extend the duration of pandemics.

Application of Imaging Algorithms for Gas-Water Two-Phase Array Fiber Holdup Meters in Horizontal Wells.

The flow dynamics of low-yield horizontal wells demonstrate considerable complexity and unpredictability, chiefly attributable to the structural attributes of the wellbore and the interplay of gas-water two-phase flow. In horizontal wellbores, precisely predicting flow patterns using conventional approaches is often problematic. Consequently, accurate monitoring and analysis of water holdup in gas-water two-phase flows are essential.

GT-NMR: a novel graph transformer-based approach for accurate prediction of NMR chemical shifts.

In this work, inspired by the graph transformer, we presented an improved protocol, termed GT-NMR, which integrates 2D molecular graph representation with Transformer architecture, for accurate yet efficient prediction of NMR chemical shifts. The effectiveness of the GT-NMR was thoroughly examined with the standard nmrshiftdb2 dataset, 37 natural products and structural elucidation of 11 pairs of natural products. Systematical analysis affirms that GT-NMR outperforms traditional graph-based methods in all aspects, achieving state-of-the-art performance, with the mean absolute error of 0.

High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China.

Food workers have frequent contact with unprocessed foods, but their carriage of Salmonella and potential influence on public health have not been comprehensively assessed. We investigated Salmonella carriage among food workers compared with non-food workers based on occupational health screening of 260,315 asymptomatic workers over an 8-year surveillance period in Yulin, China. We confirmed that healthy carriers serve as natural reservoirs for Salmonella, with higher carriage rates in food workers than non-food workers.