Publications by authors named "Xin Hua Yin"

Regenerating bone defects in diabetic rats presents a significant challenge due to the detrimental effects of reactive oxygen species and impaired autophagy on bone healing. To address these issues, a metformin-modified biomimetic silicified collagen scaffold is developed utilizing the principles of biomimetic silicification. In vitro and in vivo experiments demonstrated that the scaffold enhanced bone tissue regeneration within the diabetic microenvironment through the release of dual bio-factors.

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Respiratory tract infections are the most common triggers for heart failure in elderly people. The healthy respiratory commensal microbiota can prevent invasion by infectious pathogens and decrease the risk of respiratory tract infections. However, upper respiratory tract (URT) microbiome in the elderly is not well understood.

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Background: lncRNA, a type of non-coding RNA, plays an important role in the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs). In this study, lncRNA and mRNA microarrays were performed to study the change of gene expression during osteogenic differentiation of BM-MSCs. We focused on Hedgehog interacting protein (HHIP), because HHIP mRNA and lncRNA HHIP-AS1 were gradually down-regulated on days 0, 7, and 14 during osteogenic differentiation.

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Article Synopsis
  • A meta-analysis was conducted to compare the anesthesia effects of remifentanil combined with dexmedetomidine versus remifentanil alone in cardiac surgery, using data from various databases up to October 2021.
  • A total of 17 studies involving 1350 patients were analyzed, with 10 studies indicating that the combination provided a significantly better anesthesia effect.
  • The combination group demonstrated improved Ramsay score tests and more stable hemodynamic parameters, suggesting that remifentanil plus dexmedetomidine could be a better option for cardiac surgery anesthesia than remifentanil alone.
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Chordoma is a rare bone tumor, and the recurrence rate of chordoma is high, the treatment is difficult, and the prognosis is poor. Therefore, it is of great significance to find key target genes for the treatment of chordoma. Microarray was used to analyze the significant gene associated with chordoma.

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To report the blood pressure (BP) data obtained in the May Measurement Month (MMM) 2019 in China. Study participants were recruited if ≥18 years of age and had ideally not had their BP measured for ≥1 year. BP was measured three times consecutively with a 1-min interval in the sitting position, using a validated electronic BP monitor.

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  • Osteoporosis is a bone disease characterized by weakened bones and increased fracture risk, but traditional diagnostic methods are costly and complicated.
  • A new point-of-care system has been developed that uses a sensor to detect osteocalcin, a biomarker for bone metabolism, which allows for easier diagnosis.
  • The sensor shows a high sensitivity for osteocalcin with a detection limit of 100 pg/ml and confirmed specificity, making it a promising tool for identifying osteoporosis conditions.
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Patients with essential hypertension (EH) and hyperhomocysteinemia (HHCY) suffer from more increased thrombotic events than those in EH alone. However, the underlying mechanisms for this effect are not well understood. This study hypothesized that neutrophil extracellular trap (NET) releasing may be triggered by HHCY in patients in EH, thereby predisposing them to a more hypercoagulable state.

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  • The study focuses on enhancing bone regeneration through osteogenic differentiation using a composite material made from lanthanum and silicate substituted hydroxyapatite coated on titanium implants.
  • The bio-ceramic composite was created using a hydrothermal process and included a polymer to improve water absorption, with successful confirmation of its composition through various analytical techniques.
  • Testing showed strong cell viability and differentiation in stem cells and in a rat model, suggesting that this composite-coated titanium could be a promising material for orthopedic applications.
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Background: Oligodendrocytes (OLs) death after spinal cord injury (SCI) contributes to demyelination, even leading to a permanent neurological deficit. Besides apoptosis, our previous study demonstrated that OLs underwent receptor-interacting serine-threonine kinase 3(RIP3)/mixed lineage kinase domain-like protein (MLKL)-mediated necroptosis. Considering that necroptosis is always accompanied with pro-inflammatory response and quercetin has long been used as anti-inflammatory agent, in the present study we investigated whether quercetin could inhibit necroptosis of OLs and suppress the M1 macrophages/microglia-mediated immune response after SCI as well as the possible mechanism.

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To investigate the clinical efficacy of surgical treatment for thoracic spinal tuberculosis with kyphosis deformity via posterolateral debridement, fusion, posterior instrumentation and local continuous chemotherapy. A total of 25 patients with thoracic tuberculosis received surgery by posterolateral decompression, fusion, posterior instrumentation, and postural drainage with local continuous chemotherapy between June 2009 and October 2011. The clinical outcomes was evaluated using statistical analysis about deformity correction, bone fusion, neurologic status, and the visual analog score (VAS) and erythrocyte sedimentation rate (ESR).

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Literature about postoperative relapse of Pott's disease is rare. Accordingly, the risk factors and clinical treatments for postoperative relapse of Pott's disease remain controversial. In order to evaluate the clinical outcomes of surgical treatment of postoperative Pott's disease relapse, and to investigate its optimal therapeutic procedures with respect to focal characteristics, we performed a retrospective review of clinical and radiographic data that were prospectively collected between July 2008 and May 2014 from 753 consecutive spinal tubercular patients including 67 patients who were diagnosed and treated as postoperative relapse of Pott's disease in our hospital.

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This retrospective cohort study aimed to evaluate the clinical outcomes of posterior surgical treatment of ankylosing spondylitis (AS) with spinal tuberculosis (STB). This was a retrospective study including 12 patients treated between January 2004 and April 2014 for AS with STB at our department. All patients underwent 1-stage posterior internal fixation, debridement, and bone fusion.

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Literature reporting on lumber brucella spondylitis (LBS) is rare, therefore, the purpose of this study was to evaluate the outcomes of one-stage surgical management for lumber brucella spondylitis by anterior debridement, autogenous grafts, and instrumentation. This was a retrospective cohort study including 16 patients with lumber brucella spondylitis by treated from January 2009 to October 2011 in our department. All cases underwent one-stage anterior internal fixation, debridement, and bone fusion; clinical and radiographic results were analyzed and compared.

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Literature on the treatment of cervical spinal tuberculosis (CSTB) is uncommon, the surgical approaches to cervical spinal tuberculosis were controversial. The aim of the study was to evaluate the clinical outcomes of 3 surgical techniques in CSTB patients, and to determine the most appropriate approach for CSTB patients. Between April 2006 and June 2012, we performed a retrospective review of clinical and radiographic data that were collected from 850 consecutive spinal tubercular patients, including 87 patients who were diagnosed and treated for CSTB in our hospital.

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Flavonol (‑)‑epicatechin (EPI) is primarily contained in green tea (Camellia sinensis) and cocoa beans (Theobroma cacao), and has been demonstrated to be beneficial for the health of the cardiovascular system. However, the effect and the underlying mechanism of EPI on myocardial ischemia induced cardiac injury has not yet been determined. Therefore, the present study aimed to detect whether EPI inhibited myocardial ischemia injury.

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Objective: The aim of the present study was to investigate the inhibitory effect of wild-type P53 gene transfer on graft coronary artery disease (GCAD) after heart transplantation and the underlying mechanisms.

Methods: A rat model of heterotopic heart transplantation was established using Wistar rats as donors and Sprague-Dawley (SD) rats as recipients. The donor hearts were collected and perfused, via the coronary artery, with 800 μl of recombinant adenovirus carrying the P53 gene (Ad-P53).

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Article Synopsis
  • Musclin is a muscle-derived factor that may play a key role in regulating glucose metabolism, contributing to obesity and insulin resistance.
  • Elevated plasma musclin levels were found in overweight/obese individuals compared to lean controls, and these levels correlated positively with markers of insulin resistance and high triglycerides.
  • Experiments with rats on a high-fat diet confirmed increased musclin levels in both blood and muscle, suggesting musclin impairs glucose uptake and metabolism, potentially by inducing stress within the endoplasmic reticulum.
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Background: Musclin is a newly identified skeletal muscle-derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correlations between musclin plasma levels and various metabolic parameters in patients with type 2 diabetes mellitus.

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Article Synopsis
  • The study was a retrospective analysis aiming to evaluate the outcomes of different surgical approaches (posterior only, anterior only, and combined) for treating adults with thoracic tuberculosis over a minimum of five years.
  • A total of 184 patient records were analyzed, revealing that the posterior-only approach had significantly lower operative time, blood loss, and complications compared to the other methods, while also achieving good correction rates.
  • The findings suggest that the anterior-only approach should be used sparingly, as the combined anterior and posterior approach, although adequate, involves more trauma than the posterior-only method.
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Liraglutide, a synthetic analogue of glucagon-like peptide‑1, is utilized in the treatment of type 2 diabetes and obesity. Liraglutide has been previously demonstrated to prevent osteoblastic differentiation of human vascular smooth muscle cells, resulting in the slowing of arterial calcification, however, its effect on bone formation remains unclear. The present study investigated the effect of liraglutide on osteoblastic differentiation using Alizarin Red S staining, and examined the molecular mechanisms underlying the regulatory effect by western blot analysis.

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Objectives:: The endoplasmic reticulum (ER) stress-induced apoptotic pathway is associated with the development of acute myocardial infarction (AMI). Cortistatin (CST) is a novel bioactive peptide that inhibits apoptosis-related injury. Therefore, we investigated the cardioprotective effects and potential mechanisms of CST in a rat model of AMI.

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Cyclosporin A (CsA) is a potent immunosuppressant that has wide clinical applications for autoimmune disorders and prevention of rejection in organ transplantation. However, its liver, kidney, and heart toxicity has limited its use. In this study, we investigated the mechanism by which CsA induced cardiomyocyte apoptosis.

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Article Synopsis
  • The study compares outcomes of two surgical techniques (anterior-posterior vs. posterior-only) for treating thoracolumbar tuberculosis in children aged 5 to 14 years from 2005 to 2009.
  • A retrospective review of 47 children reveals that the posterior approach resulted in shorter operative time, less blood loss, and fewer complications compared to the anterior-posterior method, while both approaches effectively treated the disease.
  • The findings suggest that the posterior approach may be preferable, especially for children with poorer health or early stages of bone destruction.
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