Publications by authors named "Xin Guo Jiang"

Objective: To prepare and evaluate a new formulation of thermosensitive and ion-sensitive gel for nasal administration, using the volatile oil of and baicalin, the effective component extracted from .

Methods: Formulation of nasal gel of volatile oil and baicalin was prepared by using poloxamer 407 and deacetylated gellan gum as the gel base, 10% pharmasolve and 2% polysorbate 80 as the solubilizer, and 0.8% triethanolamine as the pH regulator.

View Article and Find Full Text PDF

We present a Recurrent Neural Network (RNN) Encoder-Decoder model to generate Chinese pop music lyrics to hide secret information. In particular, on a given initial line of a lyric, we use the LSTM model to generate the next Chinese character or word to form a new line. In so doing, we generate the entire lyric from what has been generated so far.

View Article and Find Full Text PDF

The efficacy and safety of recombinant tissue plasminogen activator (rtPA) need to be improved due to its low bioavailability and requirement of large dose administration. The purpose of this study was to develop a fibrin-targeted nanoparticle (NP) drug delivery system for thrombosis combination therapy. We conjugated rtPA to poly(ethylene glycol)- poly(e-caprolactone) (PEG-PCL) nanoparticles (rtPA-NP) and investigated its physicochemical characteristics such as particle size, zeta potential, enzyme activity of conjugated rtPA and its storage stability at 4°C.

View Article and Find Full Text PDF

Hyperactivated Ras regulates many oncogenic pathways in several malignant human cancers including glioblastoma and it is an attractive target for cancer therapies. Ras activation in cancer cells drives protein internalization via macropinocytosis as a key nutrient-gaining process. By utilizing this unique endocytosis pathway, here we create a biologically inspired nanostructure that can induce cancer cells to 'drink drugs' for targeting activating transcription factor-5 (ATF5), an overexpressed anti-apoptotic transcription factor in glioblastoma.

View Article and Find Full Text PDF

The development of pharmaceuticals has been providing many kinds of novel drug delivery systems, which are important for improving therapeutic effect and one of the most important fields in pharmaceutics. According to their application, we can generally divide the novel drug delivery systems into three categories: quickly performed drug delivery system, long-term drug delivery system and high effective drug delivery system. Some diseases, such as asthma, angina pectoris and migraine, require therapeutics urgently, and the drugs have to be absorbed in several minutes.

View Article and Find Full Text PDF

Rational design of the physicochemical properties of nanocarriers can optimize their pharmacokinetics, biodistribution, intratumoral penetration and tumor bioavailability. In particular, particle shape is one of the crucial parameters that can impact the circulation time, tumor accumulation and tumor cell internalization of nanocarrier. Biomimetic reconstituted high-density lipoprotein (rHDL), by mimicking the endogenous shape and structure of high-density lipoprotein, has been indicated as a promising tumor-targeting nanoparticulate drug delivery system whereas the effect of shape on tumor-targeting efficiency has not been fully evaluated.

View Article and Find Full Text PDF

Tumor is one of the most serious threats for human being. Although many anti-tumor drugs are approved for clinical use, the treatment outcome is still modest because of the poor tumor targeting efficiency and low accumulation in tumor. Therefore, it is important to deliver anti-tumor drug into tumor efficiently, elevate drug concentration in tumor tissues and reduce the drug distribution in normal tissues.

View Article and Find Full Text PDF

Objective: Airway inflammation and airway hyper-responsiveness (AHR) are principle pathological manifestations of asthma. Cluster of differentiation 69 (CD69) is a well-known co-stimulatory factor associated with the activation, proliferation as well as apoptosis of immune cells. This study aims to examine the effect of anti-CD69 monoclonal antibody (mAb) on the pathophysiology of a mouse model of asthma.

View Article and Find Full Text PDF

In recent years, the development of molecular biology and medicine has prompted the research of gene therapy for brain diseases. In this review, we summarized the current gene therapy approaches of major brain diseases. Against the pathogenesis of major brain diseases, including brain tumors, Parkinson's disease, Alzheimer's disease and cerebrovascular disorders, there are several effective gene therapy strategies.

View Article and Find Full Text PDF

A simple and sensitive liquid chromatography/positive-ion electrospray ionization mass spectrometry (LC-ESI-MS/MS) method has been developed for the simultaneous determination of sulphasalazine (SASP) and its main metabolite sulphapyridine (SP) and 5-aminosalicylic acid (5-ASA) with 100 μL of human plasma using dimenhydrinate as the internal standard (I.S.).

View Article and Find Full Text PDF

A precise and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of vinpocetine (VP) and its primary metabolite, apovincaminic acid (AVA), in rat plasma was developed and validated. The analytes and the internal standard-dimenhydrinate were extracted from 50 microL aliquots of rat plasma via solid-liquid extraction. Chromatographic separation was achieved in a run time of 3.

View Article and Find Full Text PDF

Aim: To evaluate the effect of lactoferrin (Lf) and transferrin (Tf) in brain targeting.

Methods: Polymersomes (PSs), employed as vectors, were conjugated with Lf or Tf and were characterized by morphology, particle size, zeta potential, and surface densities of the Lf or Tf molecules. In vitro uptake of Lf-PS and Tf-PS by bEnd.

View Article and Find Full Text PDF

Intranasal lidocaine hydrochloride (LID, CAS 73-78-9) has been widely and commonly used in the treatment of a series of symptoms such as migraine, cluster headache and trigeminal neuralgia in clinical studies. Nevertheless, rapid nasal mucociliary clearance of intranasal solution presents the predominant obstacle impacting its efficiency. In order to prolong the residence time of LID in the nasal cavity and increase its absorption, a LID nasal gel had been developed previously using hydroxypropyl methyl cellulose (HPMC) as base material.

View Article and Find Full Text PDF

Intranasal lidocaine hydrochloride (LID, CAS 73-78-9) has been shown useful in the control of a series of symptoms such as migraine, cluster headache and trigeminal neuralgia in clinical studies. However, rapid nasal mucociliary clearance of intranasal solution usually affects its efficiency. In this study, a nasal gel formulation was designed using hydroxypropyl methyl cellulose (HPMC) as mucoadhesive polymer to increase the residence time of LID on the nasal mucosa.

View Article and Find Full Text PDF

Objective: This study developed a nasal temperature-sensitive in situ gel system for Radix Bupleuri.

Method: Using 20% Poloxamer 407 as the gel base and 6% PEG 4000 adjusting the gelation temperature.

Results: The system is liquid at 4 degrees C.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to develop a new in situ gel system for delivering a medication (MF) for allergic rhinitis through the nasal route.
  • The gel, made with gellan gum, remained stable for 6 months at 40 degrees Celsius and was found to be safe, with no irritation in rats even after daily dosing for a month.
  • The findings showed that the gellan gum gel was more effective than standard liquid suspension in treating allergic rhinitis, indicating its potential as a better delivery method for MF.
View Article and Find Full Text PDF
Article Synopsis
  • * These nanoparticles possess internal double water channels and large interfacial areas, allowing for high drug encapsulation flexibility and stabilization of various drugs, including peptides and proteins.
  • * The study reviews the advantages of Cubosomes, such as their biodegradability, ability to control drug release for different administration routes, and protection of protein bioactivity, aiming to guide future research in drug delivery applications.
View Article and Find Full Text PDF

The pharmacokinetic parameters of two oral formulations of a 1 g dose of secnidazole (CAS 3366-95-8, secnidazole tablet as reference and another capsule preparation as test) were compared in an open-label, randomized, single oral dose, two-period cross-over design in 18 healthy volunteers under fasting conditions. Plasma concentrations of secnidazole were measured by a validated HPLC chromatographic assay. The parametric 90% confidence intervals of the geometric mean values of the test/reference ratios were 91.

View Article and Find Full Text PDF

The purpose of this study was to develop a nasal in situ gel system for Radix Bupleuri employing gellan gum as a polymer. Radix Bupleuri in situ gel containing 0.2 mL essential oil extracted from 450 g Radix Bupleuri, proper solubilizing agents and gellan gum (0.

View Article and Find Full Text PDF

Aim: To develop a novel, in situ gel system for nasal delivery of scopolamine hydrobromide (SCOP) and study its efficacy on motion sickness.

Methods: SCOP in situ gels at 0.2%, 0.

View Article and Find Full Text PDF
Article Synopsis
  • Patients with malignant gliomas have a poor prognosis due to their resistance to conventional treatments, prompting exploration of gene therapy options like Apo2L/TRAIL.
  • Recent research developed cationic albumin-conjugated pegylated nanoparticles (CBSA-NP) that can cross the blood-brain barrier, allowing for effective gene delivery.
  • The study found that when CBSA-NP-hTRAIL was administered intravenously, it successfully entered tumor cells, induced apoptosis, and significantly delayed tumor growth in mice, highlighting its potential as a noninvasive gene therapy for gliomas.
View Article and Find Full Text PDF

The aim of this study was to encapsulate nimodipine (NM) within methoxy poly(ethylene glycol)-poly(lactic acid) (MPEG-PLA) nanoparticles and to investigate its brain targeting efficiency following intranasal administration. NM-loaded nanoparticles, prepared through an emulsion/solvent evaporation technique, were characterized in terms of size, zeta potential, NM loading and in vitro release. The nanoparticles were administered intranasally to rats, and the concentrations of NM in blood, cerebrospinal fluid (CSF) and brain tissues were monitored.

View Article and Find Full Text PDF

Aim: A method of coculture of brain capillary endothelial cells (BCECs) and astrocytes of rats was used to evaluate nanoparticle's blood-brain barrier (BBB) transcytosis and toxicity at the endothelial tight junction.

Methods: A lipophilic fluorescent probe, 6-coumarin, was incorporated in poly (ethyleneglycol)-poly (lactide) nanoparticle using double emulsion/solvent evaporation method. BCECs and astrocytes were firstly isolated from brain of newborn rats and characterized by their morphology and immunocytochemistry staining, separately.

View Article and Find Full Text PDF
Article Synopsis
  • NC-1900 is an analog of arginine vasopressin that improves spatial memory deficits and passive avoidance test performance in mice, indicating its potential for treating cognitive impairments.
  • A new drug delivery system using cationic bovine serum albumin conjugated pegylated nanoparticles (CBSA-NPs) effectively carries NC-1900 to the brain and shows a sustained release profile over time.
  • Administering NC-1900 via these nanoparticles significantly enhances memory function in mice compared to direct injection of the peptide alone, highlighting the effectiveness of CBSA-NPs in targeting brain delivery.
View Article and Find Full Text PDF

Aim: To investigate the extent of systemic absorption and uptake of meptazinol (MEP) hydrochloride in cerebrospinal fluid (CSF) after intranasal administration on rats and compare with oral administration.

Methods: CSF samples were collected by a serial sampling method. The concentration of MEP in the biological samples was measured by HPLC with fluorescence detector.

View Article and Find Full Text PDF