Publications by authors named "Xin Gao"

The development of high-performance Sn-based perovskite photodetectors is presented with double-sided passivation using large alkylammonium interlayers of PEAI and BDAI₂. This dual passivation strategy, applied to the top and bottom of FASnI₃ films, effectively improves film quality by reducing defect density, enhancing carrier mobility, and minimizing non-radiative energy losses at the interfaces. At 720 nm, the photodetectors demonstrate a responsivity of 0.

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In radiology, Artificial Intelligence (AI) has significantly advanced report generation, but automatic evaluation of these AI-produced reports remains challenging. Current metrics, such as Conventional Natural Language Generation (NLG) and Clinical Efficacy (CE), often fall short in capturing the semantic intricacies of clinical contexts or overemphasize clinical details, undermining report clarity. To overcome these issues, our proposed method synergizes the expertise of professional radiologists with Large Language Models (LLMs), like GPT-3.

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Understanding the varied profiles of occupational well-being, their outcomes, and predictors is key to formulating effective strategies for enhancing teachers' occupational health and well-being. This study employed latent profile analysis (LPA) to identify distinct occupational well-being profiles and their outcomes among 366 Chinese teachers, and decision tree analysis to explore the factors predicting each profile. The results showed three occupational well-being profiles: burnout, engaged, and burnout-engaged.

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Background: Tumor necrosis factor receptor-associated factor 3 (TRAF3)-interacting protein 3 (TRAF3IP3) expressed in various tumor cell. However, its role in hepatocellular carcinoma (HCC) was unclear. We aimed to demonstrate the relationship between TRAF3IP3 and HCC and explore the potential role of TRAF3IP3 in HCC.

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Accurate prediction of binding between human leukocyte antigen (HLA) class I molecules and antigenic peptide segments is a challenging task and a key bottleneck in personalized immunotherapy for cancer. Although existing prediction tools have demonstrated significant results using established datasets, most can only predict the binding affinity of antigenic peptides to HLA and do not enable the immunogenic interpretation of new antigenic epitopes. This limitation results from the training data for the computational models relying heavily on a large amount of peptide-HLA (pHLA) eluting ligand data, in which most of the candidate epitopes lack immunogenicity.

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Background: Epidermal growth factor receptor () and mesenchymal-epithelial transition () gene mutations are well established in the pathogenesis of non-small cell lung cancer (NSCLC). However, there is limited understanding about the impact of rare variants, such as exon 20 insertion mutation (ex20ins) and exon 14 skipping mutation (ex14) in the Chinese population even though targeted therapies have been approved in China. We conducted a scoping review to assess the current available evidence of these two mutations in NSCLC in the Chinese population.

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The advent of stimulated Raman scattering (SRS) microscopy has launched a rapidly growing field in chemical imaging with broad impact. Although the physical picture seems to be well understood from classical models, prediction of absolute SRS signals remains a challenge. Here, we present a quantum electrodynamics treatment of the newly introduced stimulated Raman cross section.

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DNA barcodes, short and unique DNA sequences, play a crucial role in sample identification when processing many samples simultaneously, which helps reduce experimental costs. Nevertheless, the low quality of long-read sequencing makes it difficult to identify barcodes accurately, which poses significant challenges for the design of barcodes for large numbers of samples in a single sequencing run. Here, we present a comprehensive study of the generation of barcodes and develop a tool, PRO, that can be used for selecting optimal barcode sets and demultiplexing.

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BDE-209 exposure induced male reproductive toxicity with sperm quality decline. However, the role of autophagy in this was unclear. The purpose was to evaluate the protective effect and its potential mechanism of trehalose (Tre, autophagy inducer) on reproductive damage during spermiogenesis induced by BDE-209.

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This study aims to investigate the value of basal ganglia and limbic/paralimbic networks alteration in identifying preschool children with ASD and normal controls using diffusion basis spectrum imaging (DBSI). DBSI data from 31 patients with ASD and 30 NC were collected in Hunan Children's Hospital. All data were imported into the post-processing server.

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Background: Although many studies have reported clinical outcomes of spinal ependymoma (SE) patients after gross total resection (GTR), the data about the patient reported outcomes of the quality of life (PRO-QOL) was limited.

Purpose: This study investigated the recovery process of PRO-QOL and explored the possibility of predicting the recovery of postoperative QOL by preoperative clinical indicators.

Methods: A retrospective analysis was performed in 71 SE patients who underwent GTR in our center from 2016 to 2022.

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VOCs oxidation over transition metal catalyst is commonly understood via the Mars-van Krevelen mechanism involving the crucial role of lattice oxygen (O) activity, however, how it is influenced by atomic coordination is still unclear. Herein, we use model catalysts of CuO-cub, CuO-oct and CuO-dod with crystal planes of (100), (111) and (110), respectively, to investigate the O activity and catalytic oxidation of toluene. The activity of CuO-oct is found to be the highest, followed by CuO-cub and CuO-dod.

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Background: Breast and prostate tumors are known to be less responsive to immune checkpoint inhibitors (ICIs). Tissue-based tumor mutation burden (tTMB) has emerged as a predictive biomarker of response to ICIs, including in these "cold tumors". In clinical practice, when tTMB is not available, blood-based TMB score (bTMB) can be used to consider treatment with ICIs.

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Filamentous structures exert biological functions mediated by multivalent interactions with their counterparts in sharp contrast with spherical ones. The physicochemical properties and unique behaviors of nanofilaments that are associated with multivalent interaction with protein are poorly understood. Here, peptide-based nanofilaments containing different homotetrapeptidic inserts are reported and their protein adsorption and biological fates are tested.

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Aim: To evaluate the real-life effectiveness and safety of hydrogen inhalation (HI) therapy as an additional treatment in Chinese adults with hypertension.

Methods: This observational, retrospective clinical study included hypertensive patients receiving routine antihypertensives with or without HI initiation from 2018 to 2023. Participants were assigned to the HI group or non-HI group (control group) after propensity score matching.

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Amino acids are the main form of nitrogen in plants, and their transport across cell membranes relies on amino acid transporters (AATs). Among the plant AATs, the TaATLa subfamily comprises 18 members, yet the bioinformatics characteristics and functions of genes in common wheat remain poorly understood due to their complex genomes. This study performed genomic analyses of .

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Article Synopsis
  • * The experimental group received cBMMSC-infused conduits, while the control group had conduits without these cells; both groups were evaluated for neuron-like cell differentiation, neuronal regeneration, and axon growth after four weeks.
  • * Various methods, including immunostaining and Western blotting, were employed to assess neural recovery and functional outcomes, such as motor ability and nerve impulse transmission, in both groups.
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Dual-state emission (DSE) dyes that exhibit intense emission in both dilute solution and solid state have obtained significant attention due to their wide applications. Herein, two series of indole-based BODIPYs (IB-BODIPYs) with DSE properties are synthesized through two routes. Those dyes display yellow to red fluorescence emission in dilute solution and red to near-infrared (NIR) fluorescence emission in the solid state.

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Residue-free and highly efficient techniques for drinking water disinfection are urgently needed. Herein, we report an electrochemical water disinfection system equipped with atomically precise Ag nanoclusters (NCs) as electrode materials. The deployment of these Ag NCs not only provides sufficient electrosorption sites for intelligent microbe enrichment but also ensures high-efficiency dual-mode microbial killing through the in situ electrocatalytic production of residue-free reactive oxygen species (ROS) and the inherent antimicrobial activity of Ag NCs.

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In-situ synthesized hollow transition metal chalcogenides have gained significant attention on account of their excellent electrochemical properties. Here, Ni-doped V-MOF (V(Ni)-MOF) nanorod arrays as precursor are first grown on nickel foam (NF). Subsequently, the nanorod arrays are converted into V(NiCo)-OH hollow nanotube arrays with cross-linked nanosheets by Co etching.

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Sulfate (SO) is a pivotal inorganic anion with essential roles in mammalian physiology. NaS1, a member of solute carrier 13 family and divalent anion/sodium symporter family, functions as a Na-sulfate cotransporter, facilitating sulfate (re)absorption across renal proximal tubule and small intestine epithelia. While previous studies have linked several human disorders to mutations in the gene, its transport mechanism remains unclear.

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Article Synopsis
  • The study explores the link between hip shape and the risk of hip osteoarthritis and fractures, using data from large cohorts to analyze genetic factors influencing hip shape.
  • Researchers identified numerous genetic signals related to hip shape but found no causal effect of hip shape on osteoarthritis, while certain hip shapes were linked to a higher risk of hip fractures.
  • The findings suggest that focusing on hip shape might not be an effective strategy for preventing osteoarthritis in older adults, despite its association with hip fractures.
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Synopsis of recent research by authors named "Xin Gao"

  • - Xin Gao's recent research predominantly focuses on enhancing photocatalytic reactions, cancer treatment methodologies, and understanding metabolic diseases through advanced micro and nanotechnology applications.
  • - In his notable studies, Gao has demonstrated the use of hydrated transition metal ions to significantly increase photocatalytic pollutant degradation efficiency, as well as explored the effectiveness of the ATR inhibitor berzosertib for advanced solid tumors through a structured translational approach.
  • - Additionally, Gao's work includes investigating innovative strategies for metabolic dysfunction-related conditions, such as the comparison of intermittent and continuous calorie restriction in treating metabolic liver disease, and developing novel predictive biomarkers for liver diseases through metabolomic analyses.