The progression rate and risk factor analysis of small gastric subepithelial tumors: a systematic review and meta-analysis.

Background And Aims: Small gastric subepithelial tumors (SETs) in the stomach can be managed through surveillance or resection. However, it is still controversial how often the lesion would progress if left untreated. This study aimed to evaluate the progression rate of small SETs and identify risk factors influencing tumor growth.

Immunomodulation with M2 macrophage-derived extracellular vesicles for enhanced titanium implant osseointegration under diabetic conditions.

M2 macrophage-derived extracellular vesicles (M2-EVs) demonstrate the capacity to reduce pro-inflammatory M1 macrophage formation, thereby restoring the M1-M2 macrophage balance and promoting immunoregulation. However, the efficacy of M2-EVs in regulating macrophage polarization and subsequently enhancing osseointegration around titanium (Ti) implants in patients with diabetes mellitus (DM) remains to be elucidated. In this study, Ti implants were coated with polydopamine to facilitate M2-EVs adherence.

Myocardial Contractile Reserve Impairment in Patients with Kawasaki Disease During Convalescent Phase: A Study Based on Two-Dimensional Speckle-Tracking Stress Echocardiography.

Persistent myocardial impairment proved by histopathologic studies universally existed in patients with Kawasaki disease (KD); however, the long-term effects on myocardial contractile reserve in KD patients, especially on patients without coronary artery lesions (CALs), is still unknown. The aim of this study was to investigate myocardial contractile reserve in KD patients during late convalescent stage by speckle-tracking adenosine triphosphate (AT) echocardiography. A total of 63 antecedent KD patients at least 4 years after the disease onset and 40 age- and gender-matched normal controls were prospectively enrolled.

A roller-type triboelectric nanogenerator based on rotational friction between wool and stacked interfaces for omnidirectional wind energy harvesting.

It is urgently desired to develop high-performance wind energy collectors to power numerous microelectronic devices along with the Internet of Things (IoT). A roller-type triboelectric nanogenerator (R-TENG) based on rotational friction between wool and stacked interfaces is proposed and efficiently used for harvesting wind energy. Wool, an electropositive and flexible material, is utilized in the design, effectively reducing abrasion on the contact surface and adjusting the output in response to varying compression levels.

Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline.

Cognitive decline and memory impairment are subsequently result in neuronal apoptosis and synaptic damage. Aberrant regulation of microRNAs has been implicated in the pathogenesis of Alzheimer's disease (AD) and may play a pivotal role in the early stages of the disease. In this study, we identified the critical role of miR-4763-3p in AD pathogenesis, focusing on early-stage mild cognitive impairment (AD-MCI).

Enhancing water quality in urban areas: A spatiotemporal optimization framework for green-gray infrastructure.

Green-gray infrastructure is promising to control urban runoff and pollution, thereby mitigating the impacts of urbanization and climate change on urban water systems. In this study, we developed a novel spatiotemporal optimization framework for planning the construction of green-gray facilities. Construction timing was incorporated as an optimization variable within the framework.

Adverse reactions of immune checkpoint inhibitors combined with angiogenesis inhibitors: A pharmacovigilance analysis of drug-drug interactions.

The combination of immune checkpoint inhibitors (ICIs) and angiogenesis inhibitors (AGIs) is widely used in cancer treatment; however, drug-drug reactions (DDIs) remain unknown. We aimed to identify interaction signals for the concomitant use of ICIs and AGIs. Data were obtained from the US FDA Adverse Event Reporting System (FAERS) from January 1, 2015, to December 31, 2023.

The Photophysics of Naphthalimide-Phenoselenazine Electron Donor-Acceptor Dyads: Revisiting the Heavy-Atom Effect in Thermally Activated Delayed Fluorescence.

We prepared thermally activated delayed fluorescence (TADF) emitter dyads, NI-PTZ, NI-PTZ-2Br and NI-PSeZ, with naphthalimide (NI) as electron acceptor and 10H-phenothiazine (PTZ) or 10H-phenoselenazine (PSeZ) as electron donor to study the heavy-atom effect on the intersystem crossing (ISC) and reverse ISC (rISC) in the TADF emitters. The delayed fluorescence lifetimes of the dyads containing heavy atoms ( =5.9 μs for NI-PSeZ and =16.

DrugRepPT: a deep pretraining and fine-tuning framework for drug repositioning based on drug's expression perturbation and treatment effectiveness.

Motivation: Drug repositioning (DR), identifying novel indications for approved drugs, is a cost-effective strategy in drug discovery. Despite numerous proposed DR models, integrating network-based features, differential gene expression, and chemical structures for high-performance DR remains challenging.

Results: We propose a comprehensive deep pretraining and fine-tuning framework for DR, termed DrugRepPT.

Application of stable isotopes and mineral elements fingerprinting for beef traceability and authenticity in inner mongolia of China.

In recent years, the origin and safety of counterfeit meat products have raised significant concerns among consumers. Therefore, there was an urgent need to develop a new method using fingerprinting techniques for meat product traceability. This study aimed to evaluate the traceability and authenticity of beef from Inner Mongolia by measuring the δC and δN values, as well as 13 mineral elements.

Sorcin can trigger pancreatic cancer-associated new-onset diabetes through the secretion of inflammatory cytokines such as serpin E1 and CCL5.

A rise in blood glucose is an early warning sign of underlying pancreatic cancer (PC) and may be an indicator of genetic events in PC progression. However, there is still a lack of mechanistic research on pancreatic cancer-associated new-onset diabetes (PCAND). In the present study, we identified a gene SRI, which possesses a SNP with the potential to distinguish PCAND and Type 2 diabetes mellitus (T2DM), by machine learning on the basis of the UK Biobank database.

Advances in mRNA vaccine research in the field of quality control.

In recent years, innovative research and development of mRNA vaccines have made remarkable achievements, especially in the context of pandemic infectious diseases such as the COVID-19 virus, and the need for rapid vaccine development has further fueled the rapid growth of this field. Nevertheless, there are still gaps in our understanding of the working mechanism of mRNA vaccines and their long-term safety, efficacy, and quality control. This article summarizes the development background and production process of mRNA vaccines, outlines existing reference guidelines, quality control projects, and testing methods at home and abroad, and also summarizes the difficulties and future prospects in research and development and quality control.

When cancer patients encountered COVID-19: clinical characteristics and outcome in China.

Introduction: Cancer patients were more likely to be affected by the coronavirus disease 2019 (COVID-19) pandemic. Therefore, we analyzed the clinical characteristics and outcomes in cancer patients who were infected with COVID-19 to determine if they were more vulnerable to COVID-19 than non-cancer patients.

Methodology: This retrospective study involved 150 cancer patients and 300 non-cancer patients with a laboratory-confirmed diagnosis of COVID-19 at the Cancer Hospital of the Chinese Academy of Medical Sciences, at the end of 2022.

A novel approach to detecting microduplication in split hand/foot malformation type 3 at the single-cell level: SHFM as a case study.

Background: Split hand/foot malformation (SHFM) is a congenital limb deficiency characterized by missing or shortened central digits. Several gene loci have been associated with SHFM. Identifying microduplications at the single-cell level is challenging in clinical practice, and traditional detection methods may lead to misdiagnoses in embryos and pregnant women.

Peripheral Population Status and Habitat Suitability Assessment of the Kiang () on the Eastern Tibetan Plateau.

Shiqu County, Sichuan Province, forms the eastern edge of the distribution area of the kiang (). It is important to assess the population and habitat status of peripheral populations, as these play a significant role in the development of conservation strategies for kiangs. Based on field transect data collected from July to August 2023, this study predicted the suitable habitat distribution of kiangs in Shiqu County using a MaxEnt model and estimated the population size and density using the 'Distance' package.

Radiotherapy enhances the anti-tumor effect of CAR-NK cells for hepatocellular carcinoma.

Background: Chimeric antigen receptor (CAR)-NK cell therapy has shown remarkable clinical efficacy and safety in the treatment of hematological malignancies. However, this efficacy was limited in solid tumors owing to hostile tumor microenvironment (TME). Radiotherapy is commonly used for solid tumors and proved to improve the TME.

PresRecRF: Herbal prescription recommendation via the representation fusion of large TCM semantics and molecular knowledge.

Background: Herbal prescription recommendation (HPR) is a hotspot in the research of clinical intelligent decision support. Recently plentiful HPR models based on deep neural networks have been proposed. Owing to insufficient data, e.

Bimetallic NiCo@C with a Hollow Sea Urchin Structure Enables Li-S Batteries to Hasten the Reaction Kinetics and Effectively Inhibit the Shuttling of Polysulfides.

The "shuttle effect" and several issues related to it are seen as "obstacles" to the study and development of lithium-sulfur batteries (LSBs). This work aims at finding how to fully expose bimetallic sites and quicken the battery reaction kinetics. Here, a bimetallic NiCo-MOF and its derivative NiCo@C with a hollow sea urchin structure are produced.

Glycogenic hepatopathy associated with hepatic steatosis in type 1 diabetes.

Aims: Glycogenic hepatopathy is associated with significant psychosocial consequences and health costs. Metabolic Dysfunction-Associated Steatotic Liver Disease and glycogenic hepatopathy are frequently confused as "fatty liver" when seen on ultrasonography. We wished to examine liver fat and glycogen content in groups defined based on metabolic and liver disease phenotypes.