Effect of Mn content on the corrosion behavior and biocompatibility of biodegradable Zn-Mn alloys.

Zinc-based alloys have attracted increasing attention as biodegradable metals by virtue of their excellent mechanical, degradable and biocompatible properties. By introducing different levels of manganese (0.1, 0.

Attention-enhanced and integrated deep learning approach for fishing vessel classification based on multiple features.

Effective fisheries management is the key to achieve sustainable fisheries globally, while accurate monitoring of fishing vessels is essential to improve the effectiveness of management measures. Self-reported information on vessel types is often limited and may not cover all operating fishing vessels, causing incomplete monitoring in fisheries management. Therefore, a novel way to objectively identify the types of a large quantity of fishing vessels is needed.

Graphene-Based Far-Infrared Therapy Promotes Adipose Tissue Thermogenesis and UCP1 Activation to Combat Obesity in Mice.

Hyperthermia (HT) has broad potential for disease treatment and health maintenance. Previous studies have shown that far-infrared rays (FIRs) at 8-10 μm can potentially reduce inflammation, oxidative stress, and gut microbiota imbalance. However, the effects of FIR HT on energy metabolism require further investigation.

Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor.

Inflammatory myofibroblastic tumor (IMT) is a rare spindle-cell neoplasm. IMT currently suffers from a paucity of standardized diagnostic and therapeutic guidelines. The Chinese expert consensus committee on the diagnosis and treatment of IMT formed an "Expert consensus on the diagnosis and treatment of inflammatory myofibroblastic tumor".

Polyvinyl pyrrolidone/carboxymethyl chitosan hydrogel loaded with Paris polyphylla var. yunnanensis extracellular vesicles promotes wound healing.

Wound healing presents a persistent challenge, particularly in enhancing tissue regeneration and mitigating inflammation. Conventional wound dressings often fall short in providing adequate protection against microbial infections and do not fully support the regenerative processes necessary for effective healing. In this study, extracellular vesicles (PPEVs) were successfully isolated from Paris polyphylla var.

A new species of Darwinopterus (Wukongopteridae, Pterosauria) from western Liaoning provides some new information on the ontogeny of this clade.

The Wukongopteridae is an important pterosaur clade from the Yanliao Biota, combining features of basal and derived pterosaurs. So far, the Wukongopteridae consists of five species divided into three genera: Wukongopterus lii, Darwinopterus modularis, Darwinopterus linglongtaensis, Darwinopterus robustodens, and Kunpengopterus sinensis. Here we report a new species, Darwinopterus camposi sp.

Both carvedilol and cimetidine alleviate cisplatin-induced nephrotoxicity via downregulating OCT2.

Background: Cisplatin is a common chemotherapy agent for solid tumors but severe nephrotoxicity limits its application, with no effective pharmacological treatments. Organic cation transporter 2 (OCT2) is involved in cisplatin uptake in kidneys. This study aimed to find drugs with promising clinical applications that could prevent cisplatin-induced acute kidney injury (Cis-AKI) by inhibiting OCT2.

Circulating proteomic biomarkers for cerebral amyloid angiopathy screening and risk stratification.

Introduction: We systematically characterized plasma protein profiles in cerebral amyloid angiopathy (CAA) using proteomics and identified a hub protein panel for disease diagnosis and risk stratification.

Methods: A total of 146 patients with probable CAA and 128 community-dwelling controls were prospectively enrolled. Plasma samples underwent proteomic analysis, and the hub proteins were validated in two validation cohorts.

UTE MRI for assessing demyelination in an mTBI mouse model: An open-field low-intensity blast study.

Mild traumatic brain injury (mTBI) is a leading cause of long-term disability. Following mTBI, secondary chemical cascades and neuroinflammation can result in myelin damage, significantly impairing cognitive function. This study aims to assess demyelination in mice with mTBI induced by open-field low-intensity blast (LIB) using a novel three-dimensional short repetition time adiabatic inversion recovery UTE (3D STAIR-UTE) magnetic resonance imaging (MRI) sequence.

Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response.

Vitamin C (vitC) is essential for health and shows promise in treating diseases like cancer, yet its mechanisms remain elusive. Here, we report that vitC directly modifies lysine residues to form "vitcyl-lysine"-a process termed vitcylation. Vitcylation occurs in a dose-, pH-, and sequence-dependent manner in both cell-free systems and living cells.

Social Participation and Life Satisfaction Among Rural Older Adults in China: The Mediating Roles of Social Networks and Loneliness.

Research has shown that social participation is related to life satisfaction. However, there is no study that simultaneously examines the mediating role of social networks and loneliness in this association. This study uses data from the Well-being of Older Adults in Anhui Province (2021, = 1534).

Myelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury.

Background And Purpose: This study aims to assess the potential of ultrashort echo time imaging-based magnetization transfer ratio (UTE-MTR) in detecting demyelination in mice with mild traumatic brain injury (mTBI) caused by an open-field low-intensity blast (LIB) injury model.

Methods: This study included 30 male C57BL/6 mice, approximately 8 weeks old, sourced from Jackson Laboratories in Bar Harbor, ME, and conducted under institutional guidelines. The mice were divided into the mTBI group (n = 15) and the sham control group (n = 15).

Distinct immunophenotypic profiles and neutrophil heterogeneity in colorectal cancer.

Colorectal cancer (CRC) exhibits significant molecular and immunological heterogeneity. Neutrophil infiltration patterns play a crucial yet poorly understood role in tumor progression and patient outcomes. This study presents a comprehensive single-cell atlas of the CRC tumor microenvironment (TME), integrating transcriptomic data from 388,511 cells across 98 samples from 63 patients.

Substituent Effect of Superhalogens on the Metallodrug IMeAuCl: A DFT Study.

Halogens are usually involved in numerous anticancer drugs and play an important role in anticancer activity. Taking the IMeAuCl, a potent anticancer drug as an example, the substituent effect of superhalogens X@BN (X=F, Cl, and Br) on the structures, electronic properties, and chemical reactivity with biomolecular targets of this metallodrug has been investigated. Substituting X@BN for the Cl atom of IMeAuCl results in polar covalent bonds between Au and N atoms in the resulting Au-X (X=F, Cl, and Br) derivatives.

Unveiling the conserved nature of chloroplast genomes: insights from the assembly and analysis of four complete chloroplast genomes.

Introduction: , a genus within the Zingiberales order, is renowned for its diverse morphology, suggesting a rich genetic reservoir. However, genetic research on plants within the family has primarily focused on taxonomy and phylogenetics, with limited exploration into other genetic aspects, particularly the chloroplast genome. Given the significance of chloroplast genomes in evolutionary studies, a deeper understanding of their structure and diversity within Heliconia is essential.

The evolution of ovarian somatic cells characterized by transcriptome and chromatin accessibility across rodents, monkeys, and humans.

The ovary plays a crucial role in the reproductive system of female mammals by producing mature oocytes through folliculogenesis. Non-human model organisms are extensively utilized in research on human ovarian biology, thus necessitating the investigation of conservation and divergence in molecular mechanisms across species. In this study, we employed integrative single-cell analysis of transcriptome and chromatin accessibility to identify the evolutionary conservation and divergence patterns of ovaries among humans, monkeys, mice, rats, and rabbits.

Development and therapeutic assessment of bispecific nanobodies targeting B-cell activating factor and interleukin-17 for the neutralization of inflammatory mediators in autoimmune diseases.

Autoimmune diseases are characterized by dysregulated immune responses and chronic inflammation. B cell activating factor (BAFF) and interleukin-17 (IL-17) are key mediators in the pathogenesis of several autoimmune diseases, driving B cell hyperactivation, autoantibody production, and tissue damage. Simultaneous targeting of these pathways may provide a synergistic therapeutic approach.

Immunogenicity and safety of a COVID-19 DNA vaccine in healthy adults and elderly: A randomized, observer-blind, placebo-controlled phase 2 trial.

INO-4800 represents a DNA-based vaccine encoding the spike protein of SARS-CoV-2. This phase 2 trial evaluated the immunogenicity and safety of INO-4800 as a primary vaccination series in adults. We conducted a randomized, observer-blind, placebo-controlled phase 2 trial of intradermal injection of INO-4800 in both healthy adults and elderly individuals.

Persistent penumbral profiles indicate a potentially good outcome in acute stroke patients without major reperfusion.

Background: It is acknowledged that penumbra can exist beyond 24 h after stroke onset.

Aims: The aim of this study was to explore the association between penumbral persistence at 24-72 h and clinical outcomes in patients who did not achieve major reperfusion.

Methods: Eligible patients participating in the International Stroke Perfusion Imaging Registry with repeated 24-72 h perfusion imaging were retrospectively included in this study.

Chondroitin sulfate-based dissolvable microneedles loaded with NIR-II photothermal and natural anticancer agents for synergistic melanoma therapy.

Melanoma is characterized by its aggressiveness, high metastatic potential, and numerous mutations, which limit the effectiveness of current treatments. To address this issue, we developed a dissolvable microneedle (MN) system composed of poly(2-ethyl-2-oxazoline) (PEtOz) and chondroitin sulfate (CS). This MN system was loaded with liposomes containing both a NIR-II photothermal small molecule (IRLy) and the natural anticancer agent Gambogic acid (GA), forming Lip(IRLy + GA) MNs.

A Rare Case of Peritoneal Mesothelioma Detected by 18F-AlF-NOTA-Octreotide PET/CT.

We present a case of 37-year-old man with multiple masses in the abdominal and pelvic cavity who underwent 18F-AlF-NOTA-octreotide PET/CT. The masses demonstrated heterogeneously increased uptake on 18F-AlF-NOTA-octreotide PET/CT and were suggestive of neuroendocrine tumor. However, the histopathological examinations confirmed the masses to be peritoneal mesothelioma.

Significantly Elevated FDG Activity in Esophageal Inflammatory Myofibroblastic Tumor of a Pediatric Patient.

A 13-year-old girl presented with dysphagia underwent contrast-enhanced CT and endoscopy. The CT revealed cervical esophageal wall thickening with heterogeneous enhancement. Microscopic examination of the biopsy specimen suggested a possible mesenchymal tumor.

Structural equation modeling of the impact of disease activity on inflammatory bowel disease control: the mediating roles of self-efficacy and self-management behaviors.

Background: Maintaining effective disease control in patients with inflammatory bowel disease (IBD) is both a significant goal and challenge. Drawing on the Common-Sense Model of Self-Regulation (CSM) and related research, this study investigates how IBD activity status influences disease control through both direct and indirect pathways.

Methods: A cross-sectional survey was conducted among 310 IBD patients who attended a tertiary general hospital, the leader of the IBD Alliance Group in Chongqing City, between March and August 2024.

Causal analysis of dietary preferences and the risk of endometriosis using large-scale population data.

Dietary factors have recently been recognized as potentially influential in the pathogenesis of endometriosis (EM), yet studies on the causal relationship between dietary preferences and EM are limited. The present study aimed to explore the causal relationships between 187 dietary preferences and EM using Mendelian randomization (MR) methods. This study utilised genome-wide association study data from over 500,000 European participants for dietary preferences and 64,658 EM patients from Finland.

A deep learning approach versus expert clinician panel in the classification of posterior circulation infarction.

Background: Posterior circulation infarction (POCI) is common. Imaging techniques such as non-contrast-CT (NCCT) and diffusion-weighted-magnetic-resonance-imaging commonly fail to detect hyperacute POCI. Studies suggest expert inspection of Computed Tomography Perfusion (CTP) improves diagnosis of POCI.