Antibacterial Chitin-Based Sponges with Enhanced Water Absorbency and Mechanical Properties for Hemostasis and Wound Healing.

The development of antibacterial sponges with both high water-absorbing and mechanical properties is highly desirable for attaining efficient hemostasis and closure of noncompressible wounds, but remains challenging. General methods, such as increasing porosity, to improve the water absorption of sponges inevitably compromise their mechanical properties. Herein, a chitin (CT)/quaternized chitosan (QCS) sponge with the desirable properties was fabricated by freeze-drying the chemically and physically dual cross-linked CT/QCS hydrogel with enhanced hydrophilicity.

Black carbon in major global source areas from 2000 to 2023: Spatiotemporal variation, vertical distribution, and extreme case analysis.

Black carbon (BC) emissions in regions such as Eastern China (EC), the Indian Subcontinent (IS), Sub-Saharan Africa (SSA), and Central South America (CSA) notably affect global air quality, climate change, and human health, owing to intensive anthropogenic activities and biomass burning. Using modern-era retrospective analysis for research and applications, version 2 reanalysis data and emission inventories, we quantified the long-term spatiotemporal variations and vertical distributions of atmospheric BC and anthropogenic emissions across various sectors (2000-2023). In addition, we explored the formation mechanisms of extreme cases in representative cities (such as Beijing, Delhi, Luanda, and Sucre).

pH-triggered small molecule nanodrugs self-assembled from tryptamine-cinnamaldehyde and fisetin for targeted sepsis-associated encephalopathy therapy.

Sepsis-associated encephalopathy (SAE) is an acute diffuse brain dysfunction, but its clinical treatment just focuses on antibiotics and supportive therapy, which fail to directly limit the development of SAE. Herein, this work highlights the development of pH-triggered small molecule nanodrugs self-assembled from tryptamine (Try)-cinnamaldehyde (CA) and fisetin for targeted SAE therapy. The imine linkage in Try-CA and acid-dependent protonation of Try and fisetin endow the nanodrugs with pH-triggered dynamic changes of particle sizes, surficial charges, and drug release.

Spatiotemporal variations and source on black carbon over Chongqing, China: Long-term changes and observational experiments.

Black carbon (BC), as a critical light-absorbing constituent within aerosols, exerts profound effects on atmospheric radiation balance, climate, air quality and human health, etc. And it is also a long-standing focus in rapidly developing megacities. So, this study primarily focuses on investigating the variation characteristics and underlying causes of BC in Chongqing (31,914,300 population), which is one of the municipalities directly under the central government of China, serving as a pivotal economic hub in southwest China.

Rational use of tigecycline and tigecycline blood concentration monitoring in patients with severe infection.

Tigecycline, a tetracycline antibiotic, is widely used against antimicrobial resistance; therefore, medical staff should use tigecycline rationally to improve clinical efficacy and reduce resistance to this drug. The present study aimed to enhance the rate of rational tigecycline usage. The patients were divided into a low-dose (50 mg tigecycline twice daily, every 12 h) and a high-dose group (100 mg twice daily, every 12 h).

[Protective effect and mechanism of Angong Niuhuang pill in sepsis-associated brain dysfunction of rats].

Objective: To observe the protective effect of Angong Niuhuang pill on brain function of rats with sepsis, explore its protective mechanism, and provide the experimental basis for clinical application of Angong Niuhuang pill in the treatment of sepsis-associated encephalopathy (SAE).

Methods: Thirty male Sprague-Dawley (SD) rats were divided into sham operation group, sepsis model group and Angong Niuhuang pill group according to random number table method, with 10 rats in each group. The sepsis model was established by cecal ligation and puncture (CLP); rats in sham operation group received open and closed abdomen.

[Design and application of Checklist for quality control in intensive care unit].

Objective: To design a Checklist for quality control in intensive care unit and observe the effect of clinical application.

Methods: By consulting guidelines and literature, such as Critical care medicine professional medical quality control index (2015 edition), the quality control Checklist of intensive care unit was designed. It included four parts: quality control data collection, medical record quality verification, special diagnosis and treatment, and hospital infection prevention and control supervision.

Relationships between soil respiration and hyperspectral vegetation indexes and crop characteristics under different warming and straw application modes.

Examining the relationship between seasonal variations in soil respiration and abiotic factors and vegetation indexes is crucial for modeling soil respiration using upscaled remote sensing satellite data. A field experiment including control (CK), warming (WA), straw application (SA), and warming and straw application (WASA) treatments was performed in a winter wheat-soybean rotation cropland on the north shore of the lower reaches of the Yangtze River. Soil respiration, abiotic factors, crop hyperspectral vegetation indexes, leaf area index (LAI), and chlorophyll content (represented as the SPAD value) were measured during the 2018-2020 rotation growing seasons.

Use of polymyxin B in patients with renal impairment: A retrospective examination of 5 cases.

In order to provide an idea dose of polymyxin B in Chinese patients with renal impairment, the present study collected the clinical data of all patients with renal impairment who received polymyxin B therapy in the intensive care unit (ICU) of The First Affiliated Hospital of Bengbu Medical College (Bengbu, China). The clinical data of six patients treated in the ICU between February 2018 and May 2019 were retrospectively analyzed. All patients had renal impairment and were treated with polymyxin B combination therapy.

Price Competition and Product Differentiation Based on the Subjective and Social Effect of Consumers' Environmental Awareness.

Consumer environmental awareness (CEA) can affect green consumption decisions in different and confusing ways. In order to explain the reasons for these divergences, this study divides CEA into two main components: the subjective effect and the social effect. Then, we integrate the two effects into the classic Hotelling model to study the influence of CEA's subjective effect and social effect on price competition and product differentiation strategy.

[Changing laws of serum high mobility group box 1 protein in septic rats and the intervention effect of xuebijing].

Objective: To investigate the changing laws of serum high mobility group box 1 protein (HMGB1) in septic rats and intervention effect of Xuebijing on it.

Methods: Lipopolysaccharide (LPS) (5 mg/kg BW) was intravenously injected into the tail vein of healthy male Wistar rats to prepare the sepsis rat model. In Experiment 1: 50 Wistar rats were randomly divided into three groups, i.