Feasibility of a deep-inspiration breath-hold [F]AlF-NOTA-LM3 PET/CT imaging on upper-abdominal lesions in NET patients: in comparison with respiratory-gated PET/CT.

Purposes: To explore the clinical feasibility and efficacy of a deep inspiration breath-hold (BH) PET/CT using [F]AlF-NOTA-LM3 on upper abdominal lesions in patients with neuroendocrine tumors (NETs).

Methods: Twenty-three patients underwent a free-breath (FB) whole-body PET/CT, including a 10 min/bed scan for the upper abdomen with a vital signal monitoring for respiratory gating (RG) followed by a 20-second BH PET/CT covering the same axial range. For the upper abdomen bed, the following PET series was reconstructed: a 2-min FB PET; RG PET (6 bins); a 20-second and 15-second BH PET (BH_15 and BH_20).

Hepatic Cavernous Hemangioma Mimicking Malignancy on 18 F-FDG PET/CT Imaging.

A 65-year-old woman was referred to our hospital because of a liver lesion revealed by ultrasound and CT in an outside institution. 18 F-FDG PET/CT images revealed an FDG-avid lesion in the left lateral lobe of the liver. Malignancy cannot be excluded.

Dynamic PET/CT scan of Ga-FAPI-04 for the optimal acquisition time in suspected malignant hepatic cancer patients.

Purpose: Dynamic PET/CT scan of Ga-FAPI-04 in patients with suspected malignant hepatic lesions were retrospectively analyzed to find the optimal acquisition time with better lesion detection rate.

Methods: Twenty-two patients with lesions confirmed by CT or MRI were performed with dynamic Ga-FAPI-04 PET/CT scan. Tracer uptake of lesions and normal organs at different time points were analyzed.

Scintigraphic Imaging of Neovascularization With Tc-3PRGD for Evaluating Early Response to Endostar Involved Therapies on Pancreatic Cancer Xenografts .

Background: Molecular imaging targeting angiogenesis can specifically monitor the early therapeutic effect of antiangiogenesis therapy. We explore the predictive values of an integrin αvβ3-targeted tracer, Tc-PEG-E[PEG-c(RGDfK)] (Tc-3PRGD), for monitoring the efficacy of Endostar antiangiogenic therapy and chemotherapy in animal models.

Methods: The pancreatic cancer xenograft mice were randomly divided into four groups, with seven animals in each group and treated in different groups with 10 mg/kg/day of Endostar, 10 mg/kg/day of gemcitabine, 10 mg/kg/day of Endostar +10 mg/kg/day of gemcitabine at the same time, and the control group with 0.

Feasibility of In Vivo Imaging of Fibroblast Activation Protein in Human Arterial Walls.

Increased expression of fibroblast-activating protein (FAP) in fibrous caps may contribute to progression of atherosclerotic plaques. Forty-one patients who underwent Ga-conjugated quinoline-based FAP inhibitor (Ga-FAPI-04) PET/CT for noncardiovascular indications were retrospectively analyzed. Correlations were assessed between the uptake of Ga-FAPI-04 in large arterial walls (SUV and target-to-background ratio, TBR) and degree of calcification and cardiovascular risk factors.

A methodological investigation of healthy tissue, hepatocellular carcinoma, and other lesions with dynamic Ga-FAPI-04 PET/CT imaging.

Background: The study aimed to establish a Ga-FAPI-04 kinetic model in hepatic lesions, to determine the potential role of kinetic parameters in the differentiation of hepatocellular carcinoma (HCC) from non-HCC lesions.

Material And Methods: Time activity curves (TACs) were extracted from seven HCC lesions and five non-HCC lesions obtained from Ga-FAPI-04 dynamic positron emission tomography (PET) scans of eight patients. Three kinetic models were applied to the TACs, using image-derived hepatic artery and/or portal vein as input functions.

Comparison of PET imaging of activated fibroblasts and F-FDG for diagnosis of primary hepatic tumours: a prospective pilot study.

Purpose: This study aimed to compare the performance of Ga-labelled fibroblast activating protein inhibitor (FAPI) PET and F-FDG PET for imaging of hepatic tumours.

Methods: We prospectively assessed 20 patients with suspected intrahepatic lesions. Tumour radiological features, pathology, or follow-up examinations were assessed as ground truth in correlation with PET scans.

Characterization of myocardial oxidative metabolism and myocardial external efficiency in high-risk alcohol cardiotoxicity and alcoholic cardiomyopathy via dynamic C-Acetate positron emission tomography.

Introduction: The purpose of this study was to evaluate subjects with high-risk alcohol cardiotoxicity and patients with alcoholic cardiomyopathy (ACM) via dynamic C-Acetate positron emission tomography (PET) imaging as a myocardial oxidative metabolic probe.

Methods And Results: We recruited 37 subjects with chronic alcohol consumption [18 with moderate consumption (MC), 19 with heavy consumption (HC)], 5 ACM patients, and 12 healthy controls to receive dynamic C-Acetate PET scans. PET imaging data were analyzed to calculate kinetic parameters (e.

Fibroblast imaging of hepatic carcinoma with Ga-FAPI-04 PET/CT: a pilot study in patients with suspected hepatic nodules.

Purpose: Ga-FAPI-04 is a rapidly evolving PET tracer for whole-body imaging in a variety of cancers. We aimed to evaluate the diagnostic performance of Ga-FAPI-04 for detecting and characterizing hepatic nodules in patients with suspected carcinoma.

Methods: Twenty-five patients showing suspicious hepatic lesions for malignancy underwent Ga-FAPI-04 PET.

Myocardial tissue and metabolism characterization in men with alcohol consumption by cardiovascular magnetic resonance and 11C-acetate PET/CT.

Background: Chronic alcohol consumption initially leads to asymptomatic left ventricular dysfunction, but can result in myocardial impairment and heart failure if ongoing. This study sought to characterize myocardial tissues and oxidative metabolism in asymptomatic subjects with chronic alcohol consumption by quantitative cardiovascular magnetic resonance (CMR) and 11C-acetate positron emission tomography (PET)/computed tomography (CT).

Methods: Thirty-four male subjects (48.

99mTc-HYNIC-TOC in the Evaluation of Recurrent Tumor-Induced Osteomalacia.

Purpose: Tumor-induced osteomalacia (TIO) is rare paraneoplastic disorder generally caused by small benign neoplasm. Somatostatin receptor imaging has emerged as imaging of the choice in the localization of the causative tumors in new patients with clinical diagnosis of TIO. An accurate localization of the causative tumor using somatostatin receptor imaging followed by successful surgical removal offers cure of the disease.

Three patterns of osteoarticular involvement in SAPHO syndrome: a cluster analysis based on whole body bone scintigraphy of 157 patients.

Objectives: To explore the patterns of osteoarticular involvement in SAPHO syndrome.

Methods: Baseline clinical characteristics and imaging data of 99mTc-MDP whole-body bone scintigraphy (WBBS) were collected from 157 out of 164 patients diagnosed with SAPHO syndrome. The twelve most frequently involved osteoarticular sites were analysed by hierarchical cluster analysis with the Ward minimum-variance method.

F-18 FDG PET/CT in 26 patients with SAPHO syndrome: a new vision of clinical and bone scintigraphy correlation.

Backgrounds: Whole-body bone scintigraphy (WBBS) and MRI are widely used in assessment of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. However, the value of F-18 fluorodeoxyglucose-positron emission tomography/computed tomography (F-FDG PET/CT) in SAPHO syndrome was unclear. The aim of this study was to characterize the manifestation of SAPHO syndrome on F-FDG PET/CT and explore its relationship with clinical symptoms and WBBS.

Comparison among Reconstruction Algorithms for Quantitative Analysis of C-Acetate Cardiac PET Imaging.

Objective: Kinetic modeling of dynamic C-acetate PET imaging provides quantitative information for myocardium assessment. The quality and quantitation of PET images are known to be dependent on PET reconstruction methods. This study aims to investigate the impacts of reconstruction algorithms on the quantitative analysis of dynamic C-acetate cardiac PET imaging.

Primary Pericardial Angiosarcoma Shown on FDG PET/CT.

A 63-year-old woman had persistent bloody pericardial effusion. Tuberculous pericarditis was initially suspected, but empirical antituberculosis therapy was futile. FDG PET/CT study revealed abnormal FDG activity in multiple parts of the pericardium, especially along with aorta and main pulmonary artery, and in the left atrium.

Validation of glomerular filtration rate-estimating equations in Chinese children.

Background: Glomerular filtration rate (GFR) is essential for renal function evaluation and classification of chronic kidney disease (CKD), while the reference method in children are cumbersome. In the Chinese children, there was no data about GFR measured through plasma or renal clearance of the exogenous markers, and therefore no validated GFR-estimating tools in this population.

Methods: We measured GFR with double-sample plasma clearance of 99mTc-DTPA (mGFR) in 87 hospitalized children with renal injury.

Primary Neuroendocrine Carcinoma of the Kidney on FDG PET/CT.

A 28-year-old woman presented gradually worsening intermittent right groin pain for 10 months. FDG PET/CT was performed to evaluate the suspected renal malignancy. The images demonstrated a large hypermetabolic tumor occupying the entire right kidney.

Integrin Imaging with Tc-3PRGD2 SPECT/CT Shows High Specificity in the Diagnosis of Lymph Node Metastasis from Non-Small Cell Lung Cancer.

Purpose To evaluate an integrin imaging approach based on single photon emission computed tomography (SPECT)/computed tomography (CT) by using technetium 99m (Tc)-dimeric cyclic arginine-glycine-aspartic acid (RGD) peptides with three polyethylene glycol spacers (3PRGD2) as the tracer to target the integrin αβ expression in lung cancer and lymph node metastasis. Materials and Methods With ethics committee approval and written informed consent, 65 patients (41 male, 24 female; mean age, 60 years ± 11 [standard deviation]) with suspicious lung lesions were recruited with informed consent. The patients underwent both Tc-3PRGD2 SPECT/CT and fluorine 18 (F) fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT within 1 week.

Application of plasma clearance of iohexol in evaluating renal function in chinese children with chronic kidney disease.

Objective: To evaluate the accuracy of plasma clearance of iohexol (PCio) for glomerular filtration rate (GFR) measurement in Chinese children with chronic kidney disease (CKD) and assess the feasibility of single-blood-sample method or dried capillary blood spots in determining the PCio.

Methods: Totally 45 CKD children were included,in whom the (99m) Technetium-diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) plasma clearance and iohexol plasma clearance were simultaneously determined. Blood samples were obtained 2,4,and 5 hours after injection.

Clinical applications of 18F-FDG PET/CT in monitoring anti-cancer therapies.

Cancer is becoming the largest threat to human health. Apart from classical anti-cancer therapies such as surgery, chemotherapies, and radiotherapy, many new therapies are being developed or translated into clinical use. These therapies include various neoadjuvant chemotherapies, minimally invasive treatments, and molecular-targeted therapies.

In vivo cell tracking via ¹⁸F-fluorodeoxyglucose labeling: a review of the preclinical and clinical applications in cell-based diagnosis and therapy.

The rising interest in using functional cells for diagnosis and treatment has created an urgent need for in vivo cell-tracking techniques. Certain advanced techniques, such as those involving reporter genes or nanoparticles, are still awaiting confirmation of their safety and feasibility in human patients. Tracking cells by labeling them with (18)F-fluorodeoxyglucose, a tracer clinically used in positron emission tomography (PET), may be one way to rapidly translate some of these principles from bench to bedside.

Adenosine-stress dynamic myocardial perfusion imaging with second-generation dual-source CT: comparison with conventional catheter coronary angiography and SPECT nuclear myocardial perfusion imaging.

Objective: The purpose of this article is to evaluate the feasibility of adenosine-stress dynamic myocardial perfusion imaging (MPI) with 128-MDCT dual-source CT for detecting myocardial ischemia in comparison with conventional catheter coronary angiography and nuclear MPI.

Subjects And Methods: Thirty patients (21 men and nine women; mean [± SD] age, 59.2 ± 7.

Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model.

It has been well confirmed that brain-derived neurotrophic factor (BDNF) has therapeutic effects following stroke. However, it is difficult to be maintained at a sufficient concentration of BDNF in the infarcted hemisphere. We have shown in our previous work that BDNF fused with a collagen-binding domain (CBD-BDNF) could specifically bind to collagen.

Diffuse hepatic and splenic uptake of Tc-99m methylene diphosphonate on bone scintigraphy after intravenous administration of gadolinium-containing MRI contrast.

Three patients with known lung cancer came on different days to our department to have a bone scan to evaluate possible osseous metastatic disease. The bone scan images showed increased Tc-99m methylene diphosphonate (Tc-99m MDP) activity in the liver and to a lesser degree in the spleen, whereas bone scan images from other patients on the same days showed no abnormal activity in the liver or spleen. On the same day, shortly before the bone scan, all 3 patients had a magnetic resonance imaging scan with an intravenous injection of Magnevist (Gadolinium-DTPA), which was not previously known to cause an altered Tc-99m MDP distribution.