Publications by authors named "Ximian Liao"
Article Synopsis
- TMEM52B is a newly discovered tumor-related gene that is often overexpressed in nasopharyngeal carcinoma (NPC), correlating with more advanced cancer stages, higher recurrence rates, and shorter survival times.
- Reducing TMEM52B expression decreases NPC cell growth, movement, and invasion, indicating its importance in cancer progression.
- The gene produces two isoforms (TMEM52B-P18 and TMEM52B-P20) that differ in location and function; while both support cancer growth, TMEM52B-P20 specifically enhances metastasis by degrading E-cadherin, suggesting that targeting these isoforms might help develop new cancer treatments.
Kidney renal clear cell carcinoma (KIRC) is the most common primary renal neoplasms. Currently, there are few molecular indicators and therapeutic targets that can be used in diagnostic and prognostic assessment. In this study, we identified the C19orf10 expression in KIRC specimens and explored the diagnostic and prognostic value of C19orf10 in KIRC using TCGA and CPTAC database.
View Article and Find Full Text PDFMetastasis is the main cause of clear cell renal cell carcinoma (ccRCC) treatment failure, and the key genes involved in ccRCC metastasis remain largely unknown. We analyzed the ccRCC datasets in The Cancer Genome Atlas database, comparing primary and metastatic ccRCC tumor records in search of tumor metastasis-associated genes, and then carried out overall survival, Cox regression, and receiver operating characteristic (ROC) analyses to obtain potential prognostic markers. Comprehensive bioinformatics analysis was performed to verify that the checkpoint with forkhead associated and ring finger domains () gene is a reliable candidate oncogene, which is overexpressed in ccRCC metastatic tumor tissue, and that high expression levels of indicate a poor prognosis.
View Article and Find Full Text PDFArticle Synopsis
- Pregnancy-associated plasma protein A (PAPP-A) is a placental enzyme whose role in renal cell carcinoma (RCC) is not well understood, prompting this study to explore its expression and mechanisms in RCC.
- The research found that PAPP-A is expressed at low levels in RCC tissues and its expression correlates with patient prognosis, indicating that lower levels are associated with higher RCC-related mortality.
- Overexpressing PAPP-A in RCC cells inhibited their growth and invasiveness while altering key signaling pathways, suggesting that PAPP-A could be a valuable prognostic marker and potential therapeutic target for RCC patients.