Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences.

Unlabelled: Brain-derived neurotrophic factor (BDNF) has emerged as a new element related with insulin resistance and obesity.

Objective: To evaluate the effect of a 3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and obese subjects.

Subjects: Seventeen healthy overweight and obese subjects of both sexes (24 - 48 years, BMI 34.