Dosage of phenytoin in neurocritical patients using Bayesian algorithms: a pilot study.

Phenytoin is widely used in neurocritical patients. Owing to its high pharmacokinetic variability and narrow therapeutic range, plasma level-guided dosing has become the standard. Bayesian prediction (BP) is considered the most flexible and precise pharmacokinetic strategy among several options.

[Comparison of two methods to assess causality of adverse drug reactions].

Background: Assessment of causality is an essential part of pharmacological surveillance.

Aim: To compare the causality assessment of suspected adverse drug reactions (ADRs) using algorithms proposed by Karch-Lasagna (K & L) and the World Health Organization (WHO).

Material And Methods: All spontaneous reports of suspected ADRs in a pediatric ward of a regional hospital were included.

[Associated factors to depressive symptoms and somatic symptoms in climacteric women in the city of Temuco].

Background: Depression is an important mental health problem. The Chilean Ministry of Health has considered depression in women as one of the health priorities for the country.

Aim: To assess the prevalence of depressive and somatic symptoms and their risk factors in climacteric women.