Itaconate induces tolerance of to aminoglycoside antibiotics.

Introduction: is one of the chief pathogens that cause chronic and recurrent infections. Failure of the antibiotics to curb the infections contributes to relapse and is an important reason for the high mortality rate. Treatment failure may also be due to antibiotic tolerance.

Characterization of two multidrug-resistant harboring tigecycline-resistant gene (X4) in China.

Objectives: Tigecycline is recognized as one of the last-line antibiotics to treat serious bacterial infection caused by carbapenem-resistant (CRKP). The plasmid-borne gene (X4) mediates high resistance to tigecycline. However, the prevalence and genetic context of (X4) in from various sources are not fully understood.

Identification of Two CDK5R1-Related Subtypes and Characterization of Immune Infiltrates in Alzheimer's Disease Based on an Integrated Bioinformatics Analysis.

Background: Alzheimer's disease (AD) is a neurodegenerative disorder and the major cause of senile dementia. The Reelin pathway has been involved in both learning and AD pathogenesis. However, the specific Reelin-related gene signature during the pathological process remains unknown.

Controlling the quantity of γ-Fe inside multiwall carbon nano-onions: the key role of sulfur.

One of the most interesting structural features of multiwall carbon onions (MWCNOs) and nanotubes (MWCNTs) is the excellent chemical stability, which allows encapsulation of chosen magnetic materials of interest and multifunctional applications. In this letter, we present an innovative chemical vapour synthesis (CVS) approach, in which the inclusion of small quantities of sulfur during the pyrolysis of ferrocene/dichlorobenzene mixtures allows for an important control in the relative abundance of FCC γ-Fe, up to a maximum value of ∼86.5% (structural- and phase-control).

Particle deposition in the human lung: Health implications of particulate matter from different sources.

Although ambient particulate matter or particles have been found to be associated with morbidity and mortality all over the world, specific health effects of particles from different sources need further elucidation. The objective of this work is to predict the deposition of particles from different sources in the human lung. The whole lung, consisting of 24 generations of branches from trachea to alveoli, was approximated using a one-dimensional lumped "trumpet" model with a variable cross-sectional area.