High-Purity Generation and Switching of Twisted Single Photons.

Quantum technologies, if scaled into a high-dimensional Hilbert space, can dramatically enhance connection capabilities with supporting higher bit rates and ultrasecure information transfer. Twisted single photons, carrying orbital angular momentum (OAM) as an unbounded dimension, could address the growing demand for high-dimensional quantum information encoding and transmission. By hybrid integration of two-dimensional semiconductor WSe_{2} with a spin-orbit-coupled microring resonator, we demonstrate an integrated tunable twisted single photon source with the ability to precisely define and switch between highly pure spin-OAM states.

Topological quadratic-node semimetal in a photonic microring lattice.

Graphene, with its two linearly dispersing Dirac points with opposite windings, is the minimal topological nodal configuration in the hexagonal Brillouin zone. Topological semimetals with higher-order nodes beyond the Dirac points have recently attracted considerable interest due to their rich chiral physics and their potential for the design of next-generation integrated devices. Here we report the experimental realization of the topological semimetal with quadratic nodes in a photonic microring lattice.

Topological Photonic Lattice for Uniform Beam Splitting, Robust Routing, and Sensitive Far-Field Steering.

Far-field optical beam steering is a fast-growing technology for communications, spatial ranging, and detections. Nonmechanical optical phased arrays based on straight waveguides have been studied recently, where the beam emission angle to the propagation axis can be scanned by conveniently tuning the wavelength. However, the dispersion of the waveguide limits the wavelength sensitivity of beam steering and the deliberately created emitters inevitably introduce in-line backscattering on-chip.

The use of melittin to enhance transgene expression mediated by recombinant adeno-associated virus serotype 2 vectors both in vitro and in vivo.

Objective: Melittin, a cell-penetrating peptide, improves the efficiency of many non-viral gene delivery vectors, yet its application in viral vectors has not been well studied. The non-pathogenic recombinant adeno-associated virus (rAAV) vector is an ideal in vivo gene delivery vector. However, its full potential will only be achieved after improvement of its transduction efficiency.

The use of miR122 and its target sequence in adeno-associated virus-mediated trichosanthin gene therapy.

Objective: Plant-derived cytotoxic transgene expression, such as trichosanthin (tcs), regulated by recombinant adeno-associated virus (rAAV) vector is a promising cancer gene therapy. However, the cytotoxic transgene can hamper the vector production in the rAAV producer cell line, human embryonic kidney (HEK293) cells. Here, we explored microRNA-122 (miR122) and its target sequence to limit the expression of the cytotoxic gene in the rAAV producer cells.

Chiral flux phase in the Kagome superconductor AVSb.

We argue that the topological charge density wave phase in the quasi-2D Kagome superconductor AVSb is a chiral flux phase. Considering the symmetry of the Kagome lattice, we show that the chiral flux phase has the lowest energy among those states which exhibit 2×2 charge orders observed experimentally. This state breaks the time-reversal symmetry and displays anomalous Hall effect.