Rosendaal linear interpolation method appraising of time in therapeutic range in patients with 12-week follow-up interval after mechanical heart valve replacement.

Background: The objective of this study was to evaluate the quality of anticoagulation by the time in therapeutic range (TTR) for patients with 12-week INR follow-up interval.

Materials And Methods: From January 2018 to December 2020, a selective group of patients who underwent mechanical valve replacement and followed up at our anticoagulation clinic for adjustment of warfarin dose were enrolled. The incidences of complications of anticoagulation therapy were reported by linearized rates.

Nanotechnology, an alternative with promising prospects and advantages for the treatment of cardiovascular diseases.

Cardiovascular diseases (CVDs) are one of the most important causes of mortality and affecting the health status of patients. At the same time, CVDs cause a huge health and economic burden to the whole world. Although a variety of therapeutic drugs and measures have been produced to delay the progress of the disease and improve the quality of life of patients, most of the traditional therapeutic strategies can only cure the symptoms and cannot repair or regenerate the damaged ischemic myocardium.

Ten-year experience of tricuspid valve replacement with the St. Jude medical valve.

Bioprosthetic valves for tricuspid valve replacement (TVR) have become increasingly popular in recent years, but mechanical valves remain valuable, particularly for the patients who want to avoid reoperation for bioprostheses malfunction. The aim of this study was to review our 10-year experience in adult patients who underwent TVR with the St. Jude Medical (SJM) valve.

Primary Left Atrial Osteosarcoma.

Primary cardiac osteosarcomas are rare entities, mostly arising from the left atrium. Because of their rarity, few reports have described this uncommon lesion. We herein report a case of primary cardiac osteosarcoma originating from the left atrium in a 34-year-old woman, who underwent tumor debulking surgery and died 3 months after being diagnosed.

Echocardiographic assessment of long-term hemodynamic characteristics of mechanical mitral valve prostheses with different mitral valvular diseases.

Mitral stenosis (MS) and mitral insufficiency (MI) have different pre-operative hemodynamic characteristics. However, it is unclear if there are differences in long-term echocardiographic characteristics of MS and MI patients after mechanical mitral valve replacement. This study is to compare long-term echocardiographic results of mechanical mitral valve prostheses between MS and MI patients.

Comparison of Outcomes following Mitral Valve Repair versus Replacement for Chronic Ischemic Mitral Regurgitation: A Meta-Analysis.

 The selection of mitral valve surgery, including mitral valve repair and mitral valve replacement, is still an important dilemma for patients with chronic ischemic mitral regurgitation. We carry out a meta-analysis to evaluate the effectiveness and safety of mitral valve repair versus replacement for ischemic mitral regurgitation.  We searched PubMed, Embase, the Cochrane Library, and Web of Science to identify studies from their inception to July 2015.

Erythropoietin pretreatment suppresses inflammation by activating the PI3K/Akt signaling pathway in myocardial ischemia-reperfusion injury.

Erythropoietin (EPO), a glycoprotein originally known for its important role in the stimulation of erythropoiesis, has recently been shown to have significant protective effects in animal models of kidney and intestinal ischemia-reperfusion injury (IRI). However, the mechanism underlying these protective effects remains unclear. The aim of the current study was to evaluate the effects of EPO on myocardial IRI and to investigate the mechanism underlying these effects.

Surgical repair of inferior sinus venosus defects: a novel approach with unsnared inferior vena cava.

Background: Inferior sinus venosus defects (SVD) are very rare and difficult to image from transthoracic echocardiography. Surgical errors were occasionally reported in the repair of inferior SVDs.

Results: The authors have operated on 12 inferior SVD patients using bicaval cannulation with unsnared inferior vena cava (IVC) and proved successful.

Detection and diagnosis of iatrogenic inadvertent diversion of partial inferior vena cava into the left atrium by transesophageal echocardiography during large posteroinferior surgical atrial septal defect closure.

Iatrogenic diversion of the inferior vena cava (IVC) into the left atrium (LA) is usually reported as a rare complication following large posteroinferior atrial septal defect (ASD) surgery. It may cause acute or chronic hypoxemia, and other potentially life-threatening complications such as stroke. We present a case in which the ASD patch straddled the IVC entrance diagnosed immediately by transesophageal echocardiography (TEE) during the period of patient separated from cardiopulmonary bypass, avoiding the related complications.

[Long-term characteristics and clinical significance of echocardiogram in patients after mechanical prosthesis aortic valve replacement].

The main purpose of this study is to observe and analyze the characteristics and the clinical significance of long-term echocardiogram data in patients after mechanical aortic valve replacement operation. Fifty-five cases were recruited over 5 years after mechanical aortic valve replacement operation, with complete echocardiogram examination profiles. The 55 subjects were divided into predominate aortic stenosis group and predominate aortic regurgitation group, based on preoperative examinations.

Verification of pharmacogenetics-based warfarin dosing algorithms in Han-Chinese patients undertaking mechanic heart valve replacement.

Objective: To study the performance of pharmacogenetics-based warfarin dosing algorithms in the initial and the stable warfarin treatment phases in a cohort of Han-Chinese patients undertaking mechanic heart valve replacement.

Methods: We searched PubMed, Chinese National Knowledge Infrastructure and Wanfang databases for selecting pharmacogenetics-based warfarin dosing models. Patients with mechanic heart valve replacement were consecutively recruited between March 2012 and July 2012.

Histopathological characteristics and oxidative injury secondary to atrial fibrillation in the left atrial appendages of patients with different forms of mitral valve disease.

Background: The prevalence of atrial fibrillation (AF) and the frequency cardioversion of AF postoperatively are different in different forms of mitral valve disease. We hypothesized that these differences would relate to different extent of histopathological characteristics and oxidative injury in different forms of mitral valve diseases.

Methods: Left atrial appendages were obtained from 24 patients of mitral valve disease with or without AF undergoing mitral valve surgery.

Circulating and local renin-angiotensin-aldosterone system express differently in atrial fibrillation patients with different types of mitral valvular disease.

Mitral valvular disease is strongly related to atrial fibrillation (AF), but the different types of mitral valvular disease have a different prevalence of AF. In this study we explored the expressions of the circulating and local renin-angiotensin-aldosterone system (RAAS) in order to determine the relationship between circulating and local RAAS expressions and its effects on AF in different types of mitral valvular disease patients. Our study group consisted of 24 mitral valvular disease patients scheduled for mitral valve replacement surgery.

Differential regulation of mitogen-activated protein kinase signaling pathways in human with different types of mitral valvular disease.

Background: Mitogen-activated protein kinases (MAPKs) are considered to play a prominent role in cardiac development, function, and pathogenesis. The different types of mitral valvular disease (MVD), including mitral regurgitation (MR) and mitral stenosis (MS), have different underlying pathophysiologic changes, but the precise intracellular signal transduction mechanisms are not clear. Thus, we investigated the differential regulation of MAPK signaling pathways in humans with different types of MVD.

Eisenmenger syndrome complicated by pulmonary artery dissection.

This report describes a 40-year-old male patient diagnosed with pulmonary artery dissection involving both the left and right branches. The patient also had Eisenmenger syndrome secondary to an uncorrected patent ductus arteriosus. Diagnosis was facilitated through the use of transthoracic echocardiography and computed tomography.

Different structural remodelling in atrial fibrillation with different types of mitral valvular diseases.

Aims: The aim of this study was to determine the relationship between atrial structural remodelling and atrial fibrillation (AF) for different types of mitral valvular diseases (MVDs).

Methods And Results: Left atrial appendages tissue samples were obtained from 24 patients with MVDs undergoing mitral valve replacement surgery. Masson's trichrome staining and immunohistochemical staining were performed to assess the extent of the fibrosis.

[Doppler echocardiographic assessment of CarboMedics prosthesis in patients with mitral valve replacement].

Objective: To evaluate the CarboMedics (CM) prosthesis function two years after mitral valve replacement, and to compare the effective orifice area (EOA) calculated by pressure half-time (PHT) method and continuity method (CON).

Methods: Forty nine patients who underwent isolated mitral valve replacement with a CM prosthesis were recruited in this study, which included 13 cases of 25 mm CM prosthesis and 36 cases of 27 mm CM prosthesis. Two years after the mitral valve replacement, transthoracic echocardiography (TTE) was performed, measuring left ventricular ejection fraction (LVEF), stroke volume mean gradient (SV), PHT, peak early mitral diastolic velocity (E velocity), mean gradient (MG), time-velocity integral of left ventricular outflow tract/time-velocity integral of mitral valve prosthesis (TVI(MVP)/TVI(LVOT)).

[Tricuspid valve replacement and anticoagulation therapy: a report of 70 cases].

Objective: To evaluate the operative indication, the choice of valve prostheses, and the method of anticoagulation therapy of tricuspid valve replacement (TVR).

Methods: From May 1998 to January 2008, 70 patients underwent TVR. There were 59 cases of rheumatic heart diseases.

[Study on levels of angiotensin converting enzyme and C-reactive protein in peripheral blood of mitral valve replacement preoperative patients with atrial fibrillation].

Objective: To evaluate the levels of angiotensin converting enzyme and C-reactive protein in the peripheral blood of mitral valve replacement preoperative patients with atrial fibrillation (AF).

Methods: 24 atrial fibrillation patients, who were hospitalized for mitral valve replacement surgery, as study group (AF group) and 23 sinus rhythm patients as control group (SR group) were included in this study. The angiotensin converting enzyme and C-reactive protein in peripheral blood were quantified and compared in an attempt to find out whether the significant difference existed between the AF and SR groups.

[Impact of cardiopulmonary bypass on free amino acid spectrum in plasma for patients with prosthetic valve replacement during the perioperative period].

Objective: To investigate the impact of cardiopulmonary bypass (CPB) on free amino acid spectrum in plasma for patients with prosthetic valve replacement.

Methods: The concentrations of the free amino acid in plasma for 22 patients with prosthetic valve replacement were measured with pre-column derivatization of high-performance liquid chromatography.

Results: Compared with the preoperative data, the concentrations of some free amino acid in plasma decreased after the operation of cardiopulmonary bypass (CPB), especially some of the glucogenic amino acid and branch chain amino acid decreased significantly (P<0.

[Study on the total activity of PKC and the quantity of PKC (alpha, beta) in left auricle tissues of the patients with mitral disease and atrial fibrillation].

Objective: To investigate the possible relation of atrial fibrillation (AF) with the total activity of protein kinase C (PKC) and the quantity of PKC (alpha, beta) in the left auricle tissues of the patients with mitral disease.

Methods: Thirty-five patients hospitalized for valve replacement surgery were divided into four groups: group A (simple mitral stenosis with AF), group B(simple mitral stenosis with sinus rhythm), group C(simple mitral regurgitation with AF), group D (simple mitral regurgitation with sinus rhythm), The total PKC, activity and the quantity of PKC alpha and PKC beta were measured and compared in an attempt to find out whether significant difference exists between the groups.

Results: There was no significant difference in total PKC activity between the four groups (P > 0.