Publications by authors named "Xijun Wang"

Background: Shi Zheng (SZ, syndrome of dampness) is a major syndrome type in traditional Chinese Medicine (TCM), the ambiguity of its pathomechanism and the lack of blood diagnostic indicators have limited the understanding of the development of SZ.

Purpose: To explore the pathological mechanism of SZ and establish a symptom-centered diagnosis and treatment model.

Methods: We recruited 250 participants, including healthy individuals and patients diagnosed with SZ.

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Noninvasive phototherapy with functional preservation is considered to be a promising cancer therapeutic method. However, the clinical application of tumor phototherapy is severely restrained by the lack of appropriate multimodal phototherapy agents exhibiting an ideal tissue penetration depth to maximize the antitumor efficiency as well as to maintain important tissue functions. Herein, an innovative near-infrared ray (NIR)-triggered photodynamic-photocatalytic-photothermal therapy (PDT-PCT-PTT) agent based on an atomically dispersed cobalt single-atom enzyme (Co-SAE) anchored on hollow N-doped carbon sphere (HNCS) has been strategically developed.

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As a medicinal and food homologous substance, is renowned for its potential health benefits, including anti-tumor effects, immune system support, and anti-inflammatory properties. polypeptides have demonstrated significant biological activity, including the regulation of coagulation and lipid metabolism. However, the peptide composition of requires further clarification to facilitate quality control improvements and a deeper investigation into its pharmacological effects.

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The diagnosis and treatment of non-small cell lung cancer in clinical settings face serious challenges, particularly due to the lack of integration between the two processes, which limit real-time adjustments in treatment plans based on the patient's condition and drive-up treatment costs. Here, we present a multifunctional pH-sensitive core-shell nanoparticle containing quercetin (QCT), termed AHA@MnP/QCT NPs, designed for the simultaneous diagnosis and treatment of non-small cell lung cancer. Mechanistic studies indicated that QCT and Mn exhibited excellent peroxidase-like (POD-like) activity, catalysing the conversion of endogenous hydrogen peroxide into highly toxic hydroxyl radicals through a Fenton-like reaction, depleting glutathione (GSH), promoting reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum, and inducing ferroptosis.

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Dual-metal site catalysts (DMSCs) supported on nitrogen-doped graphene have shown great potential in heterogeneous catalysis due to their unique properties and enhanced efficiency. However, the precise control and stabilization of metal dimers, particularly in oxygen activation reactions, present significant challenges in practical applications. In this study, we integrate high-throughput density functional theory calculations with machine learning techniques to predict and optimize the catalytic properties of DMSCs.

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Background: Huangkui capsule (HKC), a Chinese patent medicine, is clinically used for treating diabetic nephropathy. However, the core disease-specific biomarkers and targets of type 2 diabetic nephropathy (T2DN) and the therapeutic mechanism of HKC are not fully elucidated.

Purpose: This study aimed to investigate the therapeutic effects and underlying molecular mechanisms of HKC for T2DN.

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Tracking atomic structural evolution along chemical transformation pathways is essential for optimizing chemical transitions and enhancing control. However, molecule-level knowledge of structural rearrangements during chemical processes remains a great challenge. Here, we couple infrared spectroscopy as a non-invasive method to probe molecular transformations, with a machine-learned protocol to immediately map the spectroscopic fingerprints to atomistic structures.

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Acanthopanax senticosus, a celebrated herbal remedy, has been cherished in China for its health-promoting properties for over two millennia. The plant's key bioactive constituent, A. senticosus polysaccharide (ASPS), has recently attracted significant interest due to its exceptional biological activities.

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Rhein is a natural active ingredient in traditional Chinese medicine that has attracted much attention due to its wide range of pharmacological activities. However, its clinical application is limited by low water solubility, poor oral absorption, and potential toxicity to the liver and kidneys. Recently, advanced extraction and synthesis techniques have made it possible to develop derivatives of rhein, which have better pharmacological properties and lower toxicity.

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ASPN-1, a novel glucan with a molecular weight of 33.31 kDa, was purified from Acanthopanax senticosus stems, characterized in structure, and evaluated for antitumor potential. The analysis of the structure of ASPN-1 revealed that it consisted of a backbone constructed from →4)-α-D-Glcp-(1 → glucosyls, branched at the O-3 position by an α-D-Glcp-(1 → residue and at the O-6 positions with α-D-Glcp-(1 → 6)-α-D-Glcp-(1 → and/or α-D-Glcp-(1 → residues.

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Ethnopharmacological Relevance: Huangkui capsule (HKC), a patent traditional Chinese medicine, has shown significant efficacy in managing chronic kidney disease (CKD), particularly diabetic nephropathy (DN). Previous studies have shown that HKC can alleviate kidney damage in DN. However, the exact mechanisms through which it exerts its effects remain unclear.

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Shenhua Tablet (SHT), a Chinese herbal medicine comprising seven crude drugs, is utilized in the treatment of immunoglobulin A nephropathy (IgAN). However, due to its complex composition, the chemical constituents of SHT in vitro are still incompletely known, which has restricted the comprehensive development and utilization of SHT in clinical practice. In the present study based on ultra-high performance liquid chromatography-quadrupole-orbitrap-linear ion trap mass spectrometry (UHPLC-Q-Orbitrap-LTQ-MS) in data dependent acquisition mode, combining the accurate mass and structural information, the profiling and characterization of chemical constituents in SHT were carried out.

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As the second most abundant polysaccharide on earth, chitin-based films are promising packaging and biomedical materials. However, the lack of special function (especially UV-blocking properties and fluorescence) usually restricts their further and high-value applications. Herein, high UV-blocking and fluorescence chitin-based films were fabricated via surface modification using acetoacetation and the Hantzsch reaction.

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Developing axial coordination engineering of single-atom nanozymes (SAzymes), directly regulating the axial coordination environment of the catalytic site, and optimizing the axial adsorption are meaningful and challenging for boosting the enzyme-like activities. Herein, the axial chlorination engineering of SAzyme with the Fe-NCl catalytic site (Fe-NCl/CNCl) was first proposed, exhibiting superior peroxidase-like activity compared to the traditional Fe-N/CN SAzyme with Fe-N site. The maximal reaction velocity (4.

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A complete goat (Capra hircus) reference genome enhances analyses of genetic variation, thus providing insights into domestication and selection in goats and related species. Here, we assemble a telomere-to-telomere (T2T) gap-free genome (2.86 Gb) from a cashmere goat (T2T-goat1.

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Guyinjian (GYJ) is a classic traditional Chinese medicine formula for the treatment of polycystic ovary syndrome, ovulation disorders, immuno-sterility, oligomenorrhea with kidney deficiency, and so forth. Due to the unclear chemical components of GYJ, the elucidation of the pharmacological mechanism, and the comprehensive development and utilization of GYJ in clinical is being restricted. In this study, ultra-high-performance liquid chromatography with quadrupole time-of-flight-tandem mass spectrometry combined with the Progenesis QI platform and using reference standards, online and self-built databases matching, fragmentation rules analysis of mass spectrometry peaks, a total of 235 compounds were preliminarily characterized, including 69 flavonoids, 65 terpenoids, 34 phenylpropanoids, 22 saccharides, sugar esters, and glycosides, 15 organic acids, and 30 others.

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Single transition metal (TM) atom embedded in nitrogen-doped carbon materials with M-N-C configuration have emerged as a promising class of electrocatalysts for electrochemical CO reduction (CORR). However, at high TM atom densities, a comprehensive understanding of the active site structure and reaction mechanisms remains a significant challenge, yet it is crucial for enhancing CORR performance. In this work, we use first-principles calculations to investigate the electrocatalytic performance of Ni-N sites for CO2 reduction to CO, co-assisted by neighboring TM atoms and a Fe nanoparticle.

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The semi-hydrogenation of acetylene in ethylene-rich gas streams is a high-priority industrial chemical reaction for producing polymer-grade ethylene. Traditional thermocatalytic routes for acetylene reduction to ethylene, despite progress, still require high temperatures and high H consumption, possess relatively low selectivity, and use a noble metal catalyst. Light-powered strategies are starting to emerge, given that they have the potential to use directly the abundant and sustainable solar irradiation, but are ineffective.

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Article Synopsis
  • Minks, cats, and other carnivores can transmit SARS-CoV-2 to humans, highlighting the need for an animal vaccine to protect both animals and people.* -
  • The mRNA vaccine SYS6006, previously successful in humans, was tested on susceptible animals and shown to be safe and effective against SARS-CoV-2.* -
  • SYS6006 induced strong and long-lasting immune responses in multiple animal species, suggesting it could be a promising solution for preventing COVID-19 in animals that could spread the virus to humans.*
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Article Synopsis
  • Natural resource polysaccharides (NRPs) are important metabolites found in cell membranes and walls of various organisms, gaining traction in medicine, food, and agriculture due to their unique bioactivities and diversity.
  • The article reviews recent advancements in NRP research from the past five years, focusing on aspects like preparation, purification, and structure-activity relationships, while also assessing extraction techniques and the link between NRP structure and biological activity.
  • It emphasizes the potential of NRPs to balance intestinal microflora, presenting them as promising candidates for probiotic development and laying a foundation for future research in this area.
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Background: Danggui Sini Decoction (DGSND) is a classic prescription for treating primary dysmenorrhea (PD), while, the ameliorating effects of DGSND on PD and its mechanisms are not yet fully understood.

Purpose: The present study is devoted to investigate the protective effect of DGSND against PD and the possible mechanism from the perspective of metabolomics as well as lipidomics.

Methods: DGSND was characterized by UPLC-Q-TOF/MS.

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Regulating the spin states in transition-metal (TM)-based single-atom catalysts (SACs), such as the TM-NC configurations, is crucial for improving the catalytic activity. However, the role of spin in single Ni atoms facilitating the electrochemical CO reduction reaction (CORR) has been largely overlooked. Using first-principles simulations, we investigated the electrocatalytic performance of Ni-N-C SACs vertically stacked on the O-terminated MXene nanosheets for the CORR.

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Article Synopsis
  • * A new cellulose acetoacetate (CAA) photoluminescent chemosensor was developed using a simple, room-temperature method that enables the synthesis of fluorescent rings, enhancing sensor properties.
  • * This sensor shows exceptional selectivity and stability for detecting iron in water, with a low detection limit of 0.48 μM, and suggests potential for creating advanced biomass-based sensors for real-time monitoring.
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As the initial point for digestion, the balance of oral microorganisms plays an important role in maintaining local and systemic health. Oral dysbiosis, or an imbalance in the oral microbial community, may lead to the onset of various diseases. The presence or abnormal increase of microbes in the oral cavity has attracted significant attention due to its complicated relationship with oral cancer.

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Background: Chemotherapy-induced Peripheral Neuropathy (CIPN) is a common complication that arises from the use of anticancer drugs. Huangqi Guizhi Wuwu Decoction (HGWWD) is an effective classic prescription for treating CIPN; however, the mechanism of the activity is not entirely understood.

Objective: This study aimed to investigate the remedial effects and mechanisms of HGWWD on CIPN.

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