Publications by authors named "Xijuan Yi"
Gen Physiol Biophys
July 2020
Article Synopsis
- The study aimed to examine how the PD-1/PD-L1 signaling pathway affects regulatory T cells (Tregs) in ovarian cancer.
- Immunohistochemistry showed that higher levels of PD-1, PD-L1, and FOXP3+ Tregs were associated with more aggressive tumors and poor patient outcomes.
- In vitro and in vivo experiments revealed that blocking PD-L1 reduced cancer cell activity and Treg differentiation, leading to decreased tumor growth and Treg recruitment in the tumor microenvironment.
Onco Targets Ther
December 2019
Article Synopsis
- Dysregulation of microRNAs (miRNAs), particularly miR-509-5p, has been linked to male infertility, with this specific miRNA being highly expressed in the testis and known to have tumor-suppressive effects in various cancers.
- A study found that miR-509-5p is significantly downregulated in germ cells from infertile men, suggesting an association between low miR-509-5p levels and male infertility issues, particularly maturation arrest.
- miR-509-5p inhibits the growth and promotes apoptosis of testicular germ cell tumor (TGCT) cells by targeting the oncogenic factor MDM2, highlighting its potential role in the development of both male infertility and TGCT
