Joint stereo 3D object detection and implicit surface reconstruction.

We present a new learning-based framework S-3D-RCNN that can recover accurate object orientation in SO(3) and simultaneously predict implicit rigid shapes from stereo RGB images. For orientation estimation, in contrast to previous studies that map local appearance to observation angles, we propose a progressive approach by extracting meaningful Intermediate Geometrical Representations (IGRs). This approach features a deep model that transforms perceived intensities from one or two views to object part coordinates to achieve direct egocentric object orientation estimation in the camera coordinate system.

VideoPro: A Visual Analytics Approach for Interactive Video Programming.

Constructing supervised machine learning models for real-world video analysis require substantial labeled data, which is costly to acquire due to scarce domain expertise and laborious manual inspection. While data programming shows promise in generating labeled data at scale with user-defined labeling functions, the high dimensional and complex temporal information in videos poses additional challenges for effectively composing and evaluating labeling functions. In this paper, we propose VideoPro, a visual analytics approach to support flexible and scalable video data programming for model steering with reduced human effort.

FedMix: Mixed Supervised Federated Learning for Medical Image Segmentation.

The purpose of federated learning is to enable multiple clients to jointly train a machine learning model without sharing data. However, the existing methods for training an image segmentation model have been based on an unrealistic assumption that the training set for each local client is annotated in a similar fashion and thus follows the same image supervision level. To relax this assumption, in this work, we propose a label-agnostic unified federated learning framework, named FedMix, for medical image segmentation based on mixed image labels.

Hydroxychloroquine administration exacerbates acute kidney injury complicated by lupus nephritis.

Background: Hydroxychloroquine (HCQ) has been recommended as a basic treatment for lupus nephritis (LN) during this decade based on its ability to improve LN-related renal immune-mediated inflammatory lesions. As a classical lysosomal inhibitor, HCQ may inhibit lysosomal degradation and disrupt protective autophagy in proximal tubular epithelial cells (PTECs). Therefore, the final renal effects of HCQ on LN need to be clarified.

Cyclosporine A blocks autophagic flux in tubular epithelial cells by impairing TFEB-mediated lysosomal function.

Cyclosporine A (CsA) is an immunosuppressor widely used for the prevention of acute rejection during solid organ transplantation. However, severe nephrotoxicity has substantially limited its long-term usage. Recently, an impaired autophagy pathway was suggested to be involved in the pathogenesis of chronic CsA nephrotoxicity.

Transferable Interactiveness Knowledge for Human-Object Interaction Detection.

Human-object interaction (HOI) Detection is an important problem to understand how humans interact with objects. In this paper, we explore Interactiveness Knowledge which indicates whether human and object interact with each other or not. We found that interactiveness knowledge can be learned across HOI datasets and alleviate the gap between diverse HOI category settings.

Prospects of and limitations to the clinical applications of genistein.

Genistein is an isoflavone derived from soy-rich products, which is known to exhibit several beneficial biological effects, such as anti-tumor activity, improvement of glucose metabolism, and reduction of the frequency of peri-menopausal hot flashes, and thus has potential for clinical application. Certain limitations and side effects, such as low bioavailability, biological estrogenic activity, and detrimental effects on thyroid function, have restricted its clinical applications to some extent. Recently, it has been reported that fermentation, use of micromicelles, and modification of its chemical structure can enhance the bioavailability of genistein.

Accelerated Glomerular Cell Senescence in Experimental Lupus Nephritis.

BACKGROUND The aim of this study was to determine whether senescence in renal glomeruli is involved in lupus nephritis (LN); the expression of senescence-associated β-galactosidase (SA-β-Gal) and its association with glomerular lesions were investigated in a mouse model of LN. MATERIAL AND METHODS Eighteen MRL/lpr mice with severe proteinuria were randomly divided into 2 equal groups and intraperitoneally injected with dexamethasone (DEX) or saline; 4 age-matched mice with mild proteinuria served as controls. Serum creatinine and urinary protein levels were analyzed, and kidney histological changes were observed by periodic acid-Schiff and Sirius Red staining.

Asiatic acid protects against cisplatin-induced acute kidney injury via anti-apoptosis and anti-inflammation.

Cisplatin is a well-known chemotherapeutic drug applied for the treatment of numerous human cancers. However, the use of cisplatin in clinic is limited by certain serious side effects, such as nephrotoxicity. Unfortunately, there is currently no effective therapeutic approach to prevent cisplatin-induced AKI.