Design, synthesis and evaluate of indazolylaminoquinazoline derivatives as potent Tropomyosin receptor kinase (TRK) inhibitors.

Tropomyosin receptor kinases (TRKs), the superfamily of transmembrane receptor tyrosine kinases, have recently become an attractive method for precision anticancer therapies since the approval of Larotrectinib and Entrectinib by FDA. Herein, we reported the discovery of a series of novel indazolylaminoquinazoline and indazolylaminoindazole as TRK inhibitors. The representative compound 30f exhibited good inhibitory activity against TRK, TRK and TRK with IC values of 0.

Synthesis of illite/iron nanoparticles and their application as an adsorbent of lead ions.

Illite/iron nanoparticles (I-nZVI) with different iron contents were synthesized using a liquid-phase reduction method to remove Pb(II) from aqueous solution. The adsorbents were characterized by Lorentz transmission electron microscopy (L-TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and the BET-N technique. The composite adsorbents and illite removed Pb(II) from aqueous solution to explore the effect of different reaction conditions, including contact time, concentration, pH, and temperature.

LC-MS determination and pharmacokinetic study of salidroside in rat plasma after oral administration of suspensions of traditional Chinese medicine and Fructus .

A simple, rapid and sensitive liquid chromatography-mass spectrometry (LC-MS) method was developed for the determination of salidroside in rat plasma and study of its pharmacokinetics after oral administration of suspension of and Fructus into Wistar rats. Plasma sample of 200 μL was extracted with acetic ether-isopropanol (2:1) and the extraction was performed on a Kromasil C column (150 mm × 4. 6 mm, 5 μm) with the mobile phase of methanol-water (41:59, v/v) within a run time of 6.