Automatic quantitative stroke severity assessment based on Chinese clinical named entity recognition with domain-adaptive pre-trained large language model.

Background: Stroke is a prevalent disease with a significant global impact. Effective assessment of stroke severity is vital for an accurate diagnosis, appropriate treatment, and optimal clinical outcomes. The National Institutes of Health Stroke Scale (NIHSS) is a widely used scale for quantitatively assessing stroke severity.

Telodendrimer functionalized hydrogel platform for sustained antibiotics release in infection control.

Wound infection commonly causes delayed healing, especially in the setting of chronic wounds. Local release of antibiotics is considered a viable approach to treat chronic wounds. We have developed a versatile telodendrimer (TD) platform for efficient loading of charged antibiotic molecules via a combination of multivalent and synergistic charge and hydrophobic interactions.

Unveiling cytokine charge disparity as a potential mechanism for immune regulation.

Cytokines are small signaling proteins that regulate the immune responses to infection and tissue damage. Surface charges of cytokines determine their in vivo fate in immune regulation, e.g.

UAV hyperspectral combined with LiDAR to estimate chlorophyll content at the stand and individual tree scales.

Chlorophyll is an important indicator of vegetation health status, accurate estimation of which is important for evaluating forest carbon sink. In this study, we estimated the chlorophyll content of coniferous forests, broad-leaved forests and mixed forest stands at stand and individual tree level by unmanned air vehicle (UAV) hyperspectral data combined with light detection and ranging (LiDAR) point clouds, which improved the non-destructive estimation accuracy of forest chlorophyll. We further comprehensively analyzed the spatial distribution of chlorophyll content at different scales.

Engineering Nanotrap Hydrogel for Immune Modulation in Wound Healing.

Imbalanced immune regulation leads to the abnormal wound healing process, e.g., chronic unhealing wound or hypertrophic scar formation.

The Regulation Network of Glycerolipid Metabolism as Coregulators of Immunotherapy-Related Myocarditis.

Background: To date, immunotherapy for patients with malignant tumors has shown a significant association with myocarditis. However, the mechanism of metabolic reprogramming changes for immunotherapy-related cardiotoxicity is still not well understood.

Methods: The CD45 single-cell RNA sequencing (scRNA-seq) of the Pdcd1Ctla4 and wild-type mouse heart in GSE213486 was downloaded to demonstrate the heterogeneity of immunocyte atlas in immunotherapy-related myocarditis.

Engineering Telodendrimer Nanocarriers for Monomeric Amphotericin B Delivery.

Systemic fungal infections are an increasingly prevalent health problem. Amphotericin B (AmB), a hydrophobic polyene antibiotic, remains the drug of choice for life-threatening invasive fungal infections. However, it has dose-limiting side effects, including nephrotoxicity.

Functionalized core-shell nanogel scavenger for immune modulation therapy in sepsis.

Sepsis is a complex, life-threatening hyperinflammatory syndrome associated with organ failure and high mortality due to lack of effective treatment options. Here we report a core-shell hydrogel nanoparticle with the core functionalized with telodendrimer (TD) nanotrap (NT) to control hyperinflammation in sepsis. The combination of multi-valent charged and hydrophobic moieties in TD enables effective binding with biomolecules in NT.

The clinical application value of compound Stachys sieboldii Miq granules to stable COPD patients.

Background: The aim of this paper was to explore the application value of Stachys sieboldii Miq granules which is a kind of traditional Chinese medicine (TCM) in stable chronic obstructive pulmonary disease (COPD) patients.

Methods: Randomized double-blind method was used to select 160 patients with stable COPD. The patients were randomly divided into placebo group and Stachys sieboldii Miq group.

Modified photochemical reflectance index to estimate leaf maximum rate of carboxylation based on spectral analysis.

The maximum rate of carboxylation in leaves (V) is an important parameter used to determine the photosynthetic rate. An accurate estimation of V is important for evaluating the photosynthetic capacity of vegetation productivity and the carbon budget of forest ecosystems. In this study, we measured the light use efficiency (LUE) and V of leaves and their corresponding spectral characteristics.

Forest age mapping based on multiple-resource remote sensing data.

Forest age is an important stand description factor and plays an important role in the carbon cycle of forest ecosystems. However, forest age data are typically lacking or are difficult to acquire at large spatial scale. Thus, it is important to develop a method of spatial forest age mapping.

Effects of compound Caoshi silkworm granules on stable COPD patients and their relationship with gut microbiota: A randomized controlled trial.

Background And Purpose: Patients with chronic obstructive pulmonary disease (COPD) usually experience recurrent acute exacerbations. These patients, especially those with stable COPD, require an effective intervention for treating exacerbations. This study aimed to evaluate the efficacy of Compound Caoshi silkworm granules (CCSGs) in stable COPD patients and to investigate their potential mechanism.

Thermally induced deterioration behaviour of two dolomitic marbles under heating-cooling cycles.

Thermally induced deterioration behaviour can cause severe weathering in marbles. Most previous studies focus on the deterioration behaviour of calcitic marbles. Relevant studies of dolomitic marbles are generally carried out under a 'high temperature and low cycling times' condition.

SWNHs (Single-Wall Carbon Nanohorns) Supervises Endoplasmic Reticulum (ER) Stress in Hepatocellular Carcinoma.

SWNHs can act as a good biocompatible nanomaterials and show potential application in the field of drug carriers or therapy to influence biological function on cell. HCC (Hepatocellular carcinoma) is a most common type of malignant neoplasms in the digestive system. SWNHs have been reported to be able to induce HepG2 cell apoptosis.

Moisture content estimation of forest litter based on remote sensing data.

As a fine fuel, forest litter plays an important role in fire danger rating systems, so forest litter moisture data are necessary and meaningful for fire risk management and prevention. An optical remote sensing technique can provide continuous and regional data for litter moisture estimates, but such an approach is restricted in separating the background reflectance of the forest floor from pixel reflectance because the litter moisture information is included only in background reflectance while pixel reflectance in the forest area consists of both canopy reflectance and background reflectance. Therefore, we present a geometrical-optical model to estimate forest litter moisture by separating contributions of background reflectance from the remote sensing image and use a statistical model to estimate the forest litter moisture content based on the calculated background reflectance.

Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices.

Respiratory assist devices, that utilize ∼2 m of hollow fiber membranes (HFMs) to achieve desired gas transfer rates, have been limited in their adoption due to such blood biocompatibility limitations. This study reports two techniques for the functionalization and subsequent conjugation of zwitterionic sulfobetaine (SB) block copolymers to polymethylpentene (PMP) HFM surfaces with the intention of reducing thrombus formation in respiratory assist devices. Amine or hydroxyl functionalization of PMP HFMs (PMP-A or PMP-H) was accomplished using plasma-enhanced chemical vapor deposition.

Influence of site index on the relationship between forest net primary productivity and stand age.

Previous studies show that forest net primary productivity (NPP) varies pronouncedly with stand age, and these variations play a crucial role in determining forest carbon sinks or sources at regional scales. Some forest carbon cycling models, eg. InTEC (The integrated terrestrial ecosystem C-budget model), calculates annual forest NPP in the long term according to normalized NPP-age relationships and the reference forest NPP at a given age.

miR-32 functions as a tumor suppressor and directly targets SOX9 in human non-small cell lung cancer.

Purpose: MicroRNA-32 (miR-32) is dysregulated in certain human malignancies and correlates with tumor progression. However, its expression and function in non-small cell lung cancer (NSCLC) remain unclear. Thus, the aim of this study was to explore the effects of miR-32 expression on NSCLC tumorigenesis and development.

Chlorophyll content retrieval from hyperspectral remote sensing imagery.

Chlorophyll content is the essential parameter in the photosynthetic process determining leaf spectral variation in visible bands. Therefore, the accurate estimation of the forest canopy chlorophyll content is a significant foundation in assessing forest growth and stress affected by diseases. Hyperspectral remote sensing with high spatial resolution can be used for estimating chlorophyll content.

Decreased microRNA-224 and its clinical significance in non-small cell lung cancer patients.

Background: MicroRNA-224 has been proven dysregulated in some human malignancies and correlated with tumor progression. However, its expression and clinical significance in non-small cell lung cancer (NSCLC) is still unclear. Thus, the aim of this study was to explore the effects of miR-224 in NSCLC tumorigenesis and development.

[Estimation of forest canopy chlorophyll content based on PROSPECT and SAIL models].

The forest canopy chlorophyll content directly reflects the health and stress of forest. The accurate estimation of the forest canopy chlorophyll content is a significant foundation for researching forest ecosystem cycle models. In the present paper, the inversion of the forest canopy chlorophyll content was based on PROSPECT and SAIL models from the physical mechanism angle.