Publications by authors named "Xiexin Wu"
Article Synopsis
- - The degeneration of nucleus pulposus cells (NPCs) is a key factor in intervertebral disc degeneration (IVDD), driven by inflammation, oxidative stress, and extracellular matrix loss, with the cannabinoid type 2 receptor (CB2) showing potential anti-inflammatory and antioxidative effects.
- - In vitro experiments demonstrated that treating NPCs with a CB2 agonist (JWH133) reduced oxidative stress, decreased inflammatory cytokine levels, and preserved important proteins like collagen II and aggrecan, while lowering matrix metalloproteinase (MMP) levels.
- - In vivo studies using a rat model indicated that JWH133 treatment improved disc morphology and slowed degeneration by inhibiting collagen II degradation and reducing M
