The comparative study of the efficacy of recombinant human brain natriuretic peptide combined with vasoactive medications for elderly patients with heart failure and hypotension receiving injections.

Background: Heart failure (HF) in elderly patients with concurrent hypotension presents a therapeutic challenge due to limited standard HF therapies' applicability. Recombinant human brain natriuretic peptide (rhBNP) and vasoactive medications have shown potential in HF management, but their combined efficacy in elderly patients with HF and hypotension remains understudied.

Methods: This retrospective cohort study included elderly HF patients with hypotension who received rhBNP alone (Group A, n = 68), rhBNP with dobutamine (Group B, n = 74), or rhBNP with dopamine (Group C, n = 71).

Superiority of Ga-DOTA-FAPI-04 PET/CT to F-FDG PET/CT in the evaluation of different cancers with bone metastases.

Background: Ga-DOTA-FAPI-04 is a new positron imaging agent, and its application in bone metastasis has been limited. The purpose of this retrospective study was to compare the diagnostic ability of Ga-DOTA-FAPI-04 PET/CT and F-FDG PET/CT to detect bone metastases in patients with different types of cancer.

Methods: A total of 293 patients with pathologically confirmed primary malignancies were examined with Ga-DOTA-FAPI-04 PET/CT and F-FDG PET/CT within one week.

Action-based two-dimensional infrared spectroscopy on the horizon.

Time domain two-dimensional infrared (2DIR) spectroscopy extends the capabilities of traditional infrared spectroscopy by revealing information on vibrational modes' anharmonicities, couplings, and energy transfer processes, making it a powerful tool for studying fast dynamic processes. Recent advancements in mid-IR laser technology and detection methods have significantly improved the resolution and acquisition rate of 2DIR spectroscopy. Despite these exciting developments, 2DIR spectroscopy remains limited by Abbe's diffraction limit, which restricts its spatial resolution.

Global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis: the International Club of Ascites GLOBAL AKI prospective, multicentre, cohort study.

Background: Acute kidney injury (AKI) is a serious complication of cirrhosis. A systematic, global characterisation of AKI occurring in patients with cirrhosis is lacking. We therefore aimed to assess global differences in the characteristics, management, and outcomes of AKI in hospitalised patients with cirrhosis.

, a gene involved in fruit development, contributes to the yield heterosis formation of hybrid F in cucumber.

Unlabelled: Heterosis has been widely applied in crops production. Nonetheless, how to determine the favorable recombination of non-alleles remains elusive. Due to the uncertainty of genetic recombination, hybrids with strong heterosis tend to be selected empirically, by developing and testing a tremendous number of combinations.

Establishment and transcriptomic characteristics of radio-resistant meningioma cell lines.

Purpose: Radio-resistance poses a significant challenge in meningioma treatment. This study aimed to establish radio-resistant meningioma cell lines and uncover molecular mechanisms driving radio-resistance to identify potential biomarkers and therapeutic targets.

Methods: Radio-resistant meningioma cell lines (IOMM-Lee-RR, CH157-RR) were developed using a progressive radiation dose (cumulative 90 Gy).

Heterogeneity in the seroprevalence of hepatitis E virus among hospital attendees: a retrospective study in Shanghai, China.

Background: Hepatitis E virus (HEV) infection is endemic in China. However, there are scarce data of HEV infection among hospital attendees seeking medical treatment or examination for various reasons.

Objective: We aim to investigate the prevalence and incidence of HEV infection by time, age, sex, and across departments in a tertiary hospital.

Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism.

Metabolic-dysfunction-associated steatohepatitis (MASH) remains a major health challenge. Herein, we identify sphingomyelin phosphodiesterase 3 (SMPD3) as a key driver of hepatic ceramide accumulation through increasing sphingomyelin hydrolysis at the cell membrane. Hepatocyte-specific Smpd3 gene disruption or pharmacological inhibition of SMPD3 alleviates MASH, whereas reintroducing SMPD3 reverses the resolution of MASH.

Aquatic photochemistry for different dissociation forms of cephalosporin antibiotics: Degradation kinetics, products and photo-modified toxicity.

Cephalosporin antibiotics (CFs) with ionizable groups (-COOH and -NH) are widely detected as emerging micropollutants that pose potential environmental risks to aquatic systems, but few studies have revealed their multivariate photochemical transformation behavior in sunlight-irradiated surface waters. In this study, the apparent photodegradation, photo-oxidation towards reactive oxygen species (ROS, •OH and O), and photo-modified toxicity were investigated for the four ionizable CFs: cefoxitin (CFX), cephalothin (CEF), cefoperazone (CFP) and cefazolin (CFZ). Under simulated sunlight irradiation (λ > 290 nm), their multivariate photo-transformation kinetics varied as a function of pHs and the dominant protonated states of the CF in question (HCFs, HCFs and CFs).

Molecular Dynamics of Apolipoprotein Genotypes APOE4 and SNARE Family Proteins and Their Impact on Alzheimer's Disease.

Alzheimer's disease is a chronic neurodegenerative disorder characterized by progressive memory loss and a significant impact on quality of life. The APOE ε4 allele is a major genetic contributor to AD pathogenesis, with synaptic dysfunction being a central hallmark in its pathophysiology. While the role of APOE4 in reducing SNARE protein levels has been established, the underlying molecular mechanisms of this interaction remain obscure.

Novel paper sensor with modified aptamer for accurate detection of clinical cardiac troponin I.

Accurate and rapid detection of Cardiac Troponin I (CTnI) is essential for the early diagnosis and timely management of myocardial infarction (MI). However, conventional detection methods relying on antigen-antibody interactions often face challenges such as high costs and lengthy procedures. Novel detection methods based on antigen-aptamer interactions offer a potentially superior alternative.

Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial.

Objectives: GLS4 is a first-in-class hepatitis B virus (HBV) capsid assembly modulator that inhibits HBV replication by interfering with assembly and disassembly of the virus nucleocapsid, this prospective, open-label, comparative, phase 2b trial evaluated the antiviral activity and safety of GLS4/ritonavir (RTV) combined with entecavir in hepatitis B e antigen-positive patients.

Methods: 250 CHB patients were enrolled, including treatment-naïve patients and those interrupted anti-HBV drugs for ≥ 6 months (Part A, n=125), and patients who had taken ETV for ≥1 year and had achieved viral suppression (Part B, n=125). Patients were randomly allocated to receive 120 mg GLS4/100 mg RTV plus 0.

Application and research progress of different frequency tACS in stroke rehabilitation: A systematic review.

After a stroke, abnormal changes in neural oscillations that are related to the severity and prognosis of the disease can occur. Resetting these abnormal neural oscillations is a potential approach for stroke rehabilitation. Transcranial alternating current stimulation (tACS) can modulate intrinsic neural oscillations noninvasively and has attracted attention as a possible technique to improve multiple post-stroke symptoms, including deficits in speech, vision, and motor ability and overall neurological recovery.

Spatiotemporal expression patterns and RNA interference efficiency of key diapause genes in Lymantria dispar-Investigating the heritability of RNA interference effects for pest biocontrol.

The spongy moth (Lymantria dispar Linnaeus), a major quarantine pest, relies on diapause as a key survival strategy. This study examined the temporal and spatial expression of four diapause-associated genes, LdGCLC, LdGLUD1_2, LdIDH1, and LdIDH2. Using fluorescence in situ hybridization and qPCR, their expression was analyzed across developmental stages and tissues.

utilizes L-arabinose to silence virulence gene expression for accelerated pathogen growth within the host.

Carbon source is an important nutrient for bacteria to sustain growth and often acts as a signal that modulates virulence expression. L-arabinose is produced by plants and plays an important role in regulating the global gene expression of bacteria. Previously, we have shown that L-arabinose induces a more severe systemic infection in -infected mice with normal microbiota, but does not affect the disease progression in mice with microbiota depleted by antibiotic treatment.

in the T11-12 Thoracic Vertebrae: A Case Report.

Background: Pyogenic thoracic spondylitis is a rare but severe infection, particularly when complicated by sepsis and acute kidney injury (AKI). Early diagnosis and precise management are essential for improving outcomes, given the limitations of traditional microbiology detection methods in identifying the causative pathogens.

Case Presentation: A 68-year-old immunocompetent male presented with recurrent fever, fatigue, loss of appetite and initial evidence of sepsis and AKI upon admission.

Reconstruction of porous media pore structure and simulation effect analysis of multi-index based on SNESIM algorithm.

The pore structure of porous media directly affects its permeability characteristics and fluid flow properties, making the accurate reconstruction of these structures of great significance. In recent years, multi-point statistics (MPS) methods have been widely used in pore structure modeling. Among them, the SNESIM algorithm, as an advanced MPS technique, has been extensively applied in the study of porous media pore structures.

A new prognostic model based on serum apolipoprotein AI in patients with HBV-ACLF and acutely decompensated liver cirrhosis.

Background/aim: To investigate the prognostic value of circulating apolipoprotein AI (apoAI) levels and develop a new prognostic model in individuals with acute-on-chronic liver failure (ACLF) and acute decompensation (AD) of liver cirrhosis caused by hepatitis B virus (HBV) infection.

Methods: Baseline levels of serum lipids were measured, and data concerning the presence of complications were collected from 561 HBV-ACLF and AD patients. Survival analysis was conducted by log-rank test.

Landau-Levich Scaling for Optimization of Quantum Dot Layer Morphology and Thickness in Quantum-Dot Light-Emitting Diodes.

Quantum dot (QD) light-emitting diodes (QLEDs) are promising candidates for next-generation displays because of their high efficiency, brightness, broad color gamut, and solution-processability. Large-scale solution-processing of electroluminescent QLEDs poses significant challenges, particularly concerning the precise control of the active layer's thickness and uniformity. These obstacles directly impact charge transport, leading to current leakage and reduced overall efficiency.

Integrated transcriptomics and metabolomics analyses provide new insights into cassava in response to nitrogen deficiency.

Nitrogen deficiency is a key constraint on crop yield. Cassava, the world's sixth-largest food crop and a crucial source of feed and industrial materials, can thrive in marginal soils, yet its yield is still significantly affected by limited nitrogen availability. Investigating cassava's response mechanisms to nitrogen scarcity is therefore essential for advancing molecular breeding and identifying nitrogen-efficient varieties.

Clinical and molecular characteristics and long-term outcomes of pediatric intracranial meningiomas: a comprehensive analysis from a single neurosurgical center.

Background: Meningioma represents the most common intracranial tumor in adults. However, it is rare in pediatric patients. We aimed to demonstrate the clinicopathological characteristics and long-term outcome of pediatric meningiomas (PMs).

Current Status and Future Directions of Artificial Intelligence in Post-Traumatic Stress Disorder: A Literature Measurement Analysis.

This study aims to explore the current state of research and the applicability of artificial intelligence (AI) at various stages of post-traumatic stress disorder (PTSD), including prevention, diagnosis, treatment, patient self-management, and drug development. We conducted a bibliometric analysis using software tools such as Bibliometrix (version 4.1), VOSviewer (version 1.

Chemical Dissipation from Outdoor Plastics: The Significant Impact of Transformation Processes Revealed by Adjusted Mass Transfer Modeling.

Chemicals in plastics raise significant concerns for potential adverse environmental and health impacts. However, dissipation kinetics and fluxes of chemicals from outdoor plastic products remain largely uncharacterized, hindering the accurate assessment of their environmental exposure. This study quantified outdoor dissipation profiles for 20 "priority" chemicals, including sunscreens (benzophenone, benzophenone-3, octyl salicylate, etc.

Thrombolytic therapy for patients with acute ischemic stroke: systematic review and network meta-analysis of randomized trials.

Objective: To systematically compare the benefits and risks of all thrombolytic agents (tenecteplase, reteplase, and alteplase) at different doses for thrombolytic therapy in patients with acute ischemic stroke (AIS).

Background: Alteplase is the cornerstone treatment for AIS, but alternative thrombolytic agents are needed. The efficacy and safety of tenecteplase and reteplase, compared to alteplase, remain unclear, as does the optimal dosing for these treatments.